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CASE REPORT article
Front. Surg.
Sec. Surgical Oncology
Volume 11 - 2024 |
doi: 10.3389/fsurg.2024.1417263
Case Report: Misdiagnosis of a Lipofibromatosis-like Neural Tumor of the Dorsal Skin as Dermatofibrosarcoma Protuberans
Provisionally accepted- Wenzhou Medical University, Wenzhou, China
Background: Lipofibromatosis-like neural tumors (LPF-NT), which have only recently been established, are intermediate soft tissue tumors with neurotrophic tropomyosin receptor kinase 1 (NTRK1) gene alterations and are typically misdiagnosed as dermatofibrosarcoma protuberans, lowgrade malignant peripheral nerve sheath tumors, or spindle cell lipoma due to their histopathological and immunohistochemical expression of CD34 and S-100.The patient was admitted to our hospital with a painless back mass that had appeared more than 4 years prior to admission. Physical examination revealed a subcutaneous mass on the back, approximately 1.5 cm in diameter and protruding into the skin, with clear boundaries and no tenderness. The tumor was surgically resected. The postoperative pathological results suggested a spindle cell soft tissue tumor, and dermatofibrosarcoma protuberan was initially considered. After consultation at a provincial hospital, the patient was diagnosed with a cutaneous lipofibromatosis-like neural tumor of the back. A second extended resection was then performed.Intraoperative rapid freezing examination revealed negative incision margins.Histological and immunohistochemical detections aid in the differential diagnosis of LPF-NTs. Complete surgical resection is the preferred treatment for LPF-NTs.
Keywords: Skin, Soft tissue tumor, lipofibromatosis-like neural tumor, Misdiagnosis, case report
Received: 14 Apr 2024; Accepted: 30 Aug 2024.
Copyright: © 2024 Zhang, Yan, Xu and Ying. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaowei Zhang, Wenzhou Medical University, Wenzhou, China
Chen Yan, Wenzhou Medical University, Wenzhou, China
Tingting Xu, Wenzhou Medical University, Wenzhou, China
Jiajia Ying, Wenzhou Medical University, Wenzhou, China
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