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ORIGINAL RESEARCH article

Front. Surg.
Sec. Cardiovascular Surgery
Volume 11 - 2024 | doi: 10.3389/fsurg.2024.1395518

Age and sex related difference of risk factors for perioperative intra-aortic balloon pumping application in patients undergoing coronary artery bypass grafting

Provisionally accepted
Junyi Gao Junyi Gao 1Yi Cheng Yi Cheng 2*Qing Zhao Qing Zhao 2
  • 1 Beijing Shijitan Hospital, Capital Medical University, Beijing, Beijing Municipality, China
  • 2 Beijing Anzhen Hospital, Capital Medical University, Chaoyang District, China

The final, formatted version of the article will be published soon.

    Background: Intra-aortic balloon pump (IABP) is a frequently utilized mechanical circulatory device in patients undergoing coronary artery bypass grafting (CABG). As a treatment for perioperative hemodynamic instability, IABP insertion often implicates adverse outcome. This study aimed to investigate age and sex related disparity of risk factors for perioperative IABP insertion in CABG patients.Methods: 2460 CABG patients were included and divided into subgroups by age (elderly subgroup: ≥ 65 years; young subgroup: < 65 years) and sex. Basic characteristics were compared between IABP and non-IABP patients in the overall patients and the subgroups. Multivariate logistic analysis was used to investigate the significant risk factors for perioperative IABP application and interaction effects among potential risk factors were analyzed. Combined receiver operating characteristic (ROC) analysis was used to evaluate the predicting value of combined risk factors.The overall patients had a mean age of 61.5 years. Application rate of perioperative IABP was 8.0%. Left ventricular ejection fraction (LVEF) < 50% significantly correlated with perioperative IABP application in the overall patients and the subgroups. Traditional factors such as myocardial infarction (MI) history, atrial fibrillation (AF) history and intraoperative estimated blood loss (EBL) were significant risk factors in certain subgroups. Small, dense low-density lipoprotein (sd-LDL) level significantly associated with IABP insertion in male subgroup and young subgroup. Area under the curve (AUC) of combined risk factors was significantly higher than AUC of LVEF < 50% alone in the overall patients as well as the subgroups.Age and sex related difference existed in risk factor distribution for perioperative IABP insertion in CABG patients.

    Keywords: Coronary Artery Bypass Grafting (CABG), Intra-aortic balloon pumping (IABP), Left ventricular ejection fraction (LVEF), age, Sex

    Received: 04 Mar 2024; Accepted: 09 Aug 2024.

    Copyright: © 2024 Gao, Cheng and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yi Cheng, Beijing Anzhen Hospital, Capital Medical University, Chaoyang District, China

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