AUTHOR=Sang Tian , Yu Fan , Zhao Junjuan , Wu Bo , Ding Xuehai , Shen Chentian 

TITLE=A novel deep learning method to segment parathyroid glands on intraoperative videos of thyroid surgery

JOURNAL=Frontiers in Surgery

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2024.1370017

DOI=10.3389/fsurg.2024.1370017

ISSN=2296-875X

ABSTRACT=<sec><title>Introduction</title><p>The utilization of artificial intelligence (AI) augments intraoperative safety and surgical training. The recognition of parathyroid glands (PGs) is difficult for inexperienced surgeons. The aim of this study was to find out whether deep learning could be used to auxiliary identification of PGs on intraoperative videos in patients undergoing thyroid surgery.</p></sec><sec><title>Methods</title><p>In this retrospective study, 50 patients undergoing thyroid surgery between 2021 and 2023 were randomly assigned (7:3 ratio) to a training cohort (<italic>n</italic> = 35) and a validation cohort (<italic>n</italic> = 15). The combined datasets included 98 videos with 9,944 annotated frames. An independent test cohort included 15 videos (1,500 frames) from an additional 15 patients. We developed a deep-learning model Video-Trans-U-HRNet to segment parathyroid glands in surgical videos, comparing it with three advanced medical AI methods on the internal validation cohort. Additionally, we assessed its performance against four surgeons (2 senior surgeons and 2 junior surgeons) on the independent test cohort, calculating precision and recall metrics for the model.</p></sec><sec><title>Results</title><p>Our model demonstrated superior performance compared to other AI models on the internal validation cohort. The DICE and accuracy achieved by our model were 0.760 and 74.7% respectively, surpassing Video-TransUnet (0.710, 70.1%), Video-SwinUnet (0.754, 73.6%), and TransUnet (0.705, 69.4%). For the external test, our method got 89.5% precision 77.3% recall and 70.8% accuracy. In the statistical analysis, our model demonstrated results comparable to those of senior surgeons (senior surgeon 1: <italic>χ</italic><sup>2</sup> = 0.989, <italic>p</italic> = 0.320; senior surgeon 2: <italic>χ</italic><sup>2</sup> = 1.373, <italic>p</italic> = 0.241) and outperformed 2 junior surgeons (junior surgeon 1: <italic>χ</italic><sup>2</sup> = 3.889, <italic>p</italic> = 0.048; junior surgeon 2: <italic>χ</italic><sup>2</sup> = 4.763, <italic>p</italic> = 0.029).</p></sec><sec><title>Discussion</title><p>We introduce an innovative intraoperative video method for identifying PGs, highlighting the potential advancements of AI in the surgical domain. The segmentation method employed for parathyroid glands in intraoperative videos offer surgeons supplementary guidance in locating real PGs. The method developed may have utility in facilitating training and decreasing the learning curve associated with the use of this technology.</p></sec>