AUTHOR=Yuan Yuan , Zhong Xian , Zhang Jian , Shen Chunming , Huang Guoxin , Zhang Jianchao , Wang Ke , Xu Ming , Shao Sheng , Yang Jun , Qian Da 

TITLE=Artificial dermis combined with split-thickness skin autograft in the treatment of hand thermal compression wounds: a single center case-control study

JOURNAL=Frontiers in Surgery

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2023.1304333

DOI=10.3389/fsurg.2023.1304333

ISSN=2296-875X

ABSTRACT=<sec><title>Objective</title><p>To explore the clinical effect of artificial dermis combined with split-thickness skin autograft in treating hand thermal compression wounds.</p></sec><sec><title>Methods</title><p>Forty-two patients in our hospital from January 2016 to October 2022 with thermal compression wounds were divided into two groups. The survival rate of autologous skin grafts seven days after skin grafting, the number of operations, total hospital stay, total hospitalization cost, and bacterial culture results of secretions were recorded. The visual analog scale was used to evaluate the wound pain. The condition of skin graft rupture was recorded and the scar status of the donor site was evaluated by the Vancouver Scar Scale.</p></sec><sec><title>Results</title><p>It showed combination of artificial dermis, split-thickness skin autograft, and vacuum sealing drainage improves the treatment of hand thermal compression wounds by enhancing the survival rate of skin grafting (95.24% &gt; 66.67%), reducing the number of operations (<italic>P</italic> &lt; 0.001), relieving wound pain (<italic>P</italic> &lt; 0.001), effectively controlling wound infection (4.76% &lt; 9.52%), and reducing the skin graft rupture rate after surgery (4.8% &lt; 28.6%). There was no evident scar hyperplasia in the donor (<italic>P</italic> = 0.003) and skin graft areas (<italic>P</italic> &lt; 0.001), which had a good recovery of hand function (<italic>P </italic>= 0.037); however, this treatment strategy may prolong the hospital stay (<italic>P </italic>= 0.030) and increase the total hospitalization cost (<italic>P</italic> = 0.030).</p></sec><sec><title>Conclusion</title><p>The composite transplantation of artificial dermis and split-thickness skin combined with the VSD significantly improves treatment and aesthetic outcomes in patients with thermal compression wounds to the hand, which is worth promoting and applying in clinical practice.</p></sec>