AUTHOR=Canu Gian Luigi , Medas Fabio , Cappellacci Federico , Rossi Leonardo , Gjeloshi Benard , Sessa Luca , Pennestrì Francesco , Djafarrian Reza , Mavromati Maria , Kotsovolis George , Pliakos Ioannis , Di Filippo Giacomo , Lazzari Giovanni , Vaccaro Carla , Izzo Martina , Boi Francesco , Brazzarola Paolo , Feroci Francesco , Demarchi Marco Stefano , Papavramidis Theodossios , Materazzi Gabriele , Raffaelli Marco , Calò Pietro Giorgio , REDHOT Study Collaborative Group , Anedda Giacomo , Soddu Cristina , Casti Francesco , Biancu Miriam , Puddu Silvia , Russo Selina , De Palma Andrea , Pignatelli Francesco , Loguercio Elisa , Palmieri Livia , Salvi Giulia , Procopio Priscilla Francesca , Morelli Eleonora , Serbusca Dorin , Giordano Alessio Biagio Filippo , Fiorenza Giulia , Leboulleux Sophie , Massé Nathalie TITLE=Risk factors for postoperative cervical haematoma in patients undergoing thyroidectomy: a retrospective, multicenter, international analysis (REDHOT study) JOURNAL=Frontiers in Surgery VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2023.1278696 DOI=10.3389/fsurg.2023.1278696 ISSN=2296-875X ABSTRACT=Background

Postoperative cervical haematoma represents an infrequent but potentially life-threatening complication of thyroidectomy. Since this complication is uncommon, the assessment of risk factors associated with its development is challenging. The main aim of this study was to identify the risk factors for its occurrence.

Methods

Patients undergoing thyroidectomy in seven high-volume thyroid surgery centers in Europe, between January 2020 and December 2022, were retrospectively analysed. Based on the onset of cervical haematoma, two groups were identified: Cervical Haematoma (CH) Group and No Cervical Haematoma (NoCH) Group. Univariate analysis was performed to compare these two groups. Moreover, employing multivariate analysis, all potential independent risk factors for the development of this complication were assessed.

Results

Eight thousand eight hundred and thirty-nine patients were enrolled: 8,561 were included in NoCH Group and 278 in CH Group. Surgical revision of haemostasis was performed in 70 (25.18%) patients. The overall incidence of postoperative cervical haematoma was 3.15% (0.79% for cervical haematomas requiring surgical revision of haemostasis, and 2.35% for those managed conservatively). The timing of onset of cervical haematomas requiring surgical revision of haemostasis was within six hours after the end of the operation in 52 (74.28%) patients. Readmission was necessary in 3 (1.08%) cases. At multivariate analysis, male sex (P < 0.001), older age (P < 0.001), higher BMI (P = 0.021), unilateral lateral neck dissection (P < 0.001), drain placement (P = 0.007), and shorter operative times (P < 0.001) were found to be independent risk factors for cervical haematoma.

Conclusions

Based on our findings, we believe that patients with the identified risk factors should be closely monitored in the postoperative period, particularly during the first six hours after the operation, and excluded from outpatient surgery.