AUTHOR=Tanaka Haku , Nishimura Fumihiko , Nakase Kenta , Yokoyama Shohei , Nakagawa Ichiro , Yamada Shuichi , Tamura Kentaro , Matsuda Ryosuke , Takeshima Yasuhiro , Kotsugi Masashi , Park Young-Soo , Nakase Hiroyuki 

TITLE=Case report: Giant pituitary neuroendocrine tumor presented along with acute visual loss due to pituitary apoplexy after receiving COVID-19 vaccination

JOURNAL=Frontiers in Surgery

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2023.1220098

DOI=10.3389/fsurg.2023.1220098

ISSN=2296-875X

ABSTRACT=<sec><title>Objective</title><p>A case of giant pituitary neuroendocrine tumor presented along with acute visual loss due to pituitary apoplexy after receiving a COVID-19 vaccination is reported.</p></sec><sec><title>Case presentation</title><p>A 45-year-old man was referred for a giant pituitary tumor with bitemporal hemianopsia. A surgical procedure was planned and then delayed due to the COVID-19 outbreak in Japan, with a Pfizer/BioNTech vaccine administered while awaiting surgery. Three days after the second COVID-19 vaccination the patient noted a progressively worsening headache that caused pituitary apoplexy and then a decrease in vision. Emergency surgery was thus performed.</p></sec><sec><title>Conclusion</title><p>Pituitary apoplexy is a rare and life-threatening complication that may occur after undergoing a COVID-19 vaccination.</p></sec>