Erheng Liu
Heng Zhao2
Chengyuan Liu
Chao Luo
Shuaifeng Yang- 1Department of Neurosurgery, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China
- 2Department of Neurosurgery, The First People's Hospital of Yunnan Province, Kunming, China
Moyamoya disease (MMD) is an idiopathic cerebrovascular disease which was first described by Suzuki and Takaku in 1969. Moyamoya disease is a non-atherosclerotic cerebrovascular structural disorder. MMD has been found all over the world, especially in Japan, Korea, and China. In recent years, many reports pointed out that the changes of vascular stenosis in patients with moyamoya disease occurred not only in intracranial vessels, but also in extracranial vessels, especially the changes of renal artery. Renovascular hypertension (RVH) is considered to be one of the important causes of hypertension in patients with moyamoya disease. The pathogenesis of moyamoya disease combined with renovascular hypertension is still unclear, and the selection of treatment has not yet reached a consensus. This article reviews the latest research progress in epidemiology, RNF213 gene, pathomorphology, clinical characteristics and treatment of moyamoya disease combined with renovascular hypertension, in order to provide reference for clinical workers.
Introduction
Moyamoya disease is a non-atherosclerotic cerebrovascular structural disorder. It was first discovered and described by Japanese scholars in 1,957 (1). This disease is characterized by bilateral carotid stenosis or occlusion, and abnormal vascular network at the bottom of the brain (2, 3). The pathogenetic mechanisms remain to be fully elucidated. The prevalence of hypertension in patients with moyamoya disease ranges from 5.7% to 38.9% (4–6). Bleeding is the leading cause of death in patients with moyamoya disease, and hypertension is associated with increased mortality (7). In recent years, many reports have pointed out that the changes of vascular stenosis in patients with moyamoya disease occurred not only in intracranial vessels, but also in extra cranial vessels, especially the changes of renal artery (8–11). Renovascular hypertension is considered to be one of the important causes of hypertension in patients with moyamoya disease (6). The pathogenesis of moyamoya disease combined with renovascular hypertension is still unclear, and the selection of treatment has not yet reached a consensus. This article reviews the latest research progress in epidemiology, RNF213 gene, pathomorphology, clinical characteristics and treatment of moyamoya disease combined with renovascular hypertension, in order to provide reference for clinical workers.
Literature search
Articles in the PubMed and Web of Science databases were searched to identify articles related to MMD and renovascular hypertension findings as of 1 July 2022. The titles and abstracts of those articles were reviewed by two reviewers to confirm their quality and eligibility for further examination. The inclusion criteria were as follows: (1) MMD/MMS and renovascular hypertension were simultaneously mentioned in the title or abstract, and (2) original studies or case reports. Other relevant articles and reviews were considered. The final bibliography is based on originality and relevance to the subject. The exclusion criteria were as follows: (1) non-English article; (2) Comments, clinical trials were ruled out.
Based on the inclusion and exclusion criteria, a total of 57 eligible articles were identified and reviewed, and the year of publication ranged from 1988 to 2022. Due to space constraints, we do not drill down into statistical disaggregation.
Epidemiology
In western countries, the most common causes of renal vascular hypertension (RVH) in children are fibromuscular dysplasia (FMD) and Takayasu arteritis (12, 13). However, a study in Asia found that the most common cause of RVH in children was MMD, followed by FMD (5). It has been reported that the incidence of renal artery stenosis in renal vessels of patients with moyamoya disease is 5%–8%, which is one of the common extra cranial vascular changes (8, 14, 15). The small difference between the different reports may be due to the fact that the differences related to age and vascular risk factors in the study were not excluded. In the Asian Study of Children with Moyamoya Disease, Jin Wook Baek (4) studied 101 children with moyamoya disease, 8 of whom (7.9%) had renal artery stenosis and 6 of whom (6%) had hypertension. Five of these six hypertensive patients had renal artery stenosis (83%) and only one patient was diagnosed with primary hypertension. The statistical analysis also revealed that the higher the angiography stage of patients with moyamoya disease was, the more renal artery stenosis was found in the study. In another large study in Asia, 40 of 706 pediatric patients with MMD (5.7%) had hypertension (HTN) and 22 of these 40 patients had renal artery stenosis (6). In a Korean study of adults, only 1 of 63 patients (2%) with MMD was diagnosed with renal artery stenosis (11). The large difference may be due to the difference in age stratification among study samples or it may be related to the late onset moyamoya disease in adults. There may also be geographical differences, as in a European study in which renal artery stenosis was found in 4 of 20 children (20%) with moyamoya disease (16). Only angiography was performed in the study, no patients were operated on or necropsied, and the histopathological diagnosis of renal artery stenosis was not confirmed. Therefore, it cannot be concluded that renal artery stenosis was solely caused by extra cranial vascular involvement in a patient with moyamoya disease. There is currently no incidence of renal artery stenosis in the general population. Interestingly, in a long-term follow-up of children with moyamoya disease in South Korea, angiography confirmed the occurrence of new renal artery stenosis in normal renal arteries in three patients (17). Therefore, renal artery involvement may be more frequent in patients with chronic moyamoya disease, and the true prevalence of renal artery stenosis may be underestimated. Current studies are mostly in Southeast Asian countries, which is also consistent with the incidence of moyamoya disease (18–20). There are few studies on adult moyamoya disease complicated with renal artery stenosis, which may be related to the fact that early-onset moyamoya disease is more likely to be complicated with renal artery stenosis.
Genes-RNF213
Clinical studies have shown that the RNF213 gene variant is associated with systemic vascular disease as well as intracranial vascular lesions in MMD (10, 15, 21–23). The polymorphism r4810k (p.Arg4810Lys) in the ring finger protein 213 (RNF213) gene on chromosome 17q25.3 was identified as the strongest genetic susceptibility factor for MMD in the east asian population using whole-genome linkage and economics analysis (24). Known as a mystery protein, RNF213 encodes the 591-kDa protein “cyclophilin 213”, which has two AAA + modules (ATP enzymes associated with various cellular activities) and a cyclophilin ubiquitin lipase domain (25). In two homozygous cases of the r4810k variant for moyamoya disease and pulmonary artery stenosis reported by Fukushima and his colleagues, one of them had renal artery stenosis, suggesting that the r4810k variant causes classical moyamoya disease when present in the heterozygous state, but that the same variant causes moyamoya disease and systemic vascular disease in a gene dose-dependent manner when present in the homozygous state (10, 21). Severe early onset disorders associated with de novo mutation of RNF213 in a ring fin domain and a limited region defined by amino acids 4, 114 to 4, 120 downstream of that domain have been reported.This phenotype is characterized by early and progressive moyamoya disease in infancy or early childhood with other arterial occlusions, including the abdominal, renal, femoral and iliac arteries (15). The absence of the RNF213 p.R4810K variant has been suggested as a possible novel biomarker for identifying severe forms of childhood moyamoya disease (26). While the exact function of the gene RNF213 and the mechanism of the genetic variation leading to the disease are unknown, a mouse model deficient in RNF213 demonstrates abnormal angiogenesis and response to vascular injury (27, 28). Liver and kidney manifestations associated with the gene RNF213 variant have also been clinically described. For example, children with moyamoya disease have right renal dysplasia and young adult patients with moyamoya disease have polycystic kidney disease (29, 30). Alanna Strong et al. (31) report two cases of congenital presentation of liver, kidney, and skin disorders in children with severe MMD presented a novel multiple organ syndrome associated with neonatal RNF213 genetic variation in patients with moyamoya disease. In another study, 93.8% of pediatric patients with moyamoya disease HTN had heterozygous or homozygous forms of the RNF213 p.r4810k variant, and the renovascular hypertension (RVH) to non-RVH ratio in patients with moyamoya disease hypertension (HTN) and homozygous variants of RNF213 p.R4810K was 8.3, also reflecting the possibility that the RNF213 p.r4810k variant may contribute to renal artery stenosis of RVH (6). These cases all point to the RNF213 gene, so it is possible that patients with moyamoya disease associated with variants of the RNF213 gene have unique liver and kidney phenotypes. Mutations at different sites in RNF213 may have a variety of vascular effects, but the genotypic-phenotypic associations of rare variants of RNF213 have not been well studied in large patient cohorts (6, 32–34). Whether the RNF213 polymorphism in MMD is a gain-of function or loss-of- function mutation remains to be elucidated. In addition to genetic factors, multiple injuries such as autoimmune reaction, ischemia, infection and radiation may be necessary for the occurrence of moyamoya disease (28, 35–37). It is therefore unknown whether the RNF213 polymorphism in moyamoya disease is a function loss or function acquisition mutation.
16 genes are currently involved in moyamoya disease vasculopathy. Renovascular hypertension is also described in the literature with the exception of RNF 213 (38, 39). For example, in a case of progressive and symptomatic moyamoya disease vasculopathy caused by hemizygous deletion of BRCC3/MTCP1, he underwent left renal allotransplantation and right nephrectomy for renovascular hypertension in infancy (40). A child with Down's syndrome with moyamoya syndrome presented with renovascular hypertension with symptoms of left ventricular hypertrophy and heart failure (41). Therefore, many moyamoya vascular susceptibility genes may be involved in moyamoya disease or moyamoya syndrome complicated with renovascular hypertension, which needs further research in the future.
Morphological pathology
At present, there are few articles about the correlation between intracranial vessels and renal vascular morphological pathology in patients with moyamoya disease. Intracranial vascular pathology of moyamoya disease is characterized by fibrous thickening of the intima and a small amount of lipid deposition, the internal elastic layer is well preserved, and there is no obvious inflammatory cell infiltration in the vascular wall (42, 43). In Japan, a histopathological and morphometric analysis of intracranial and extracranial vessels in 13 necropsy cases of patients with moyamoya disease pointed out that the intimal thickness of pulmonary, renal and pancreatic arteries was statistically significant, and morphological research results strongly indicated that moyamoya disease involved not only intracranial but also extracranial vessels, and there were systemic etiological factors leading to systemic intimal thickening (9). In a recent case report (44), aortography of a young patient with moyamoya disease revealed a severe stenosis (stenosis >75%) of the left renal artery at the proximal lesion, while the right renal artery was unaffected. However, the stenosis progressively worsened until the flow to the left renal artery was completely interrupted, and a left nephrectomy was performed. Histopathological examination of the excised left renal artery revealed eccentric intimal fibers and medial thickening, with irregular fluctuations of the inner elastic layer, and similar findings were observed in arterioles of the renal parenchyma, such as interlobular or interlobular arteries. He later underwent a living donor kidney transplantation, with the remaining right kidney removed simultaneously. Interestingly, in the histopathology of his right kidney, a narrow vascular lumen was observed from interlobular to interlobular arteries in the right renal parenchyma, which was similar to the left kidney, but the right renal artery was pathologically intact. Although there was no lesion in the right renal artery, pathological facts suggest that refractory hypertension may also be associated with peripheral vasculopathy of the right renal parenchyma. Renal vascular morphology similar to intracranial vessels has also been presented in multiple sporadic case reports (45–48).
Clinical features
At present, studies on patients with moyamoya disease RVH mostly focus on children (4, 6, 11, 44). In a study of childhood moyamoya disease by Heeyeon Cho et al. (6) more women than men presented with a male to female ratio of 1: 86 in RVH and the mean ages at diagnosis of HTN and MMD were 10.9 ± 5.2 and 6.5 ± 3.7 years, respectively, with a body mass index of 19.7 ± 5.8. MMD and HTN were diagnosed at younger ages and with lower body indices compared to the non-RVH group. In another study (5), about half of the 10 patients with RVH of moyamoya disease developed hypertension-related symptoms at the time of diagnosis of moyamoya disease. It has been reported that the nervous system of children with moyamoya disease accompanied by renal artery stenosis and hypertension was not significantly worse (17). This may be due to successful bypass surgery in these patients during childhood. However, patients with renal artery stenosis tend to be younger when moyamoya disease is diagnosed, and the disease is more severe (higher Suzuki classification) and statistically significant (4). In other case studies (45, 46), younger patients with moyamoya disease were diagnosed at 8 months of age with slowly progressive hypertension, ineffective salt-limited diet, and resistance to antihypertensive drugs in some patients. Abdominal murmurs can be heard in some patients (43, 47). At present, there are few studies on the clinical characteristics of adult patients with moyamoya disease RVH (11, 49). In a study of the clinical characteristics of pregnancy and delivery in patients with moyamoya disease, it was pointed out that pregnant women with MMD accompanied by renal artery stenosis were more likely to suffer from hypertensive disorder complicating pregnancy (49). In a study by Jizong Zhao et al. (50) 156 of 542 adult MMD patients (28.8%) had hypertension with a mean age of 43.6 ± 8.49 years at the time of diagnosis, but unfortunately the etiology was not investigated in this study. In the imaging diagnosis, the renal artery stenosis may be unilateral or bilateral, and the renal artery stenosis part is mainly located near 1/3 of the main renal artery (5, 6, 11, 14). Plasma renin activity could be elevated in laboratory tests, and in an earlier study six pediatric patients with moyamoya disease combined with VRH had elevated plasma renin (47). Increases in plasma renin have also been reported in sporadic reports (51, 52).
Treatment
Worldwide, the treatment of moyamoya disease combined with renal hypertension is mainly in case reports and retrospective analysis. At present, the treatment of moyamoya disease combined with renovascular hypertension (RVH) is divided into three types. The first type is intravascular intervention, mainly balloon angioplasty. The second type is surgical treatment, mainly autotransplantation. The third type is drug treatment (5, 47, 53). Balloon angioplasty is a mainstream therapy for the treatment of renovascular hypertension, and has been used for the treatment of many cases of renovascular hypertension related to moyamoya disease. However, there is no large-scale study on the effectiveness of treatment for renal artery lesions in patients with moyamoya disease. In a retrospective analysis of nine patients with moyamoya disease complicated by RVH treated with PTA, three patients with MMD showed improvement after the first PTA, but two of them experienced restenosis and required a second PTA, and six patients with MMD showed no change in blood pressure after the first PTA (5). Choi et al. (47) reported the success of balloon angioplasty in only one of four patients with moyamoya disease RVH. In an 18-month-old baby girl, although renal blood flow was immediately restored after the first PTA surgery, severe stenosis developed 1 year later (54). Therefore, simple balloon angioplasty (PTA) seems to be difficult to effectively control the blood pressure of patients with moyamoya disease combined with RVH, and the recurrence rate is high. Some people think that stent implantation should be the first choice for angioplasty in patients with moyamoya disease, but there are no relevant treatment reports on patients with moyamoya disease (51). An example of treatment by Choi et al. (47) was a renal autotransplantation following a failed angioplasty (PTA) procedure that still required antihypertensive medications. Renin-angiotensin-aldosterone system antagonists, calcium channel blockers, and β-receptor blockers have contributed to the successful control of blood pressure in many patients with RVH, but there have been no large-scale prospective or retrospective studies regarding drug therapy in patients with moyamoya disease complicated with RVH (55–57).
Discussion Neurologists should recognize moyamoya disease as a disease that can be associated with extracranial vascular changes, particularly renal artery stenosis, which is a high incidence in patients with moyamoya disease and which may lead to nephrogenic hypertension. The degree of vasculopathy in patients with moyamoya disease is usually progressive. Early detection of renal arterial lesions is valuable in the treatment of patients with moyamoya disease. Renovascular hypertension may first appear even in pediatric patients before they develop moyamoya disease, which may provide a prediction for moyamoya disease. Renovascular hypertension can be a clinically relevant systemic manifestation during the treatment of patients with moyamoya disease. Clinicians should recognize that early diagnosis of renovascular hypertension is important to prevent hypertension-related conditions and reduce mortality. When hypertension is found, young age and low weight may indicate the existence of moyamoya disease, and such patients should be screened for intracranial vascular diseases to rule out moyamoya disease. It is suggested that MMD patients should be carefully screened for hypertension, especially for homozygous R4810K variant and elevated plasma renin activity to rule out renal artery stenosis. A Doppler ultrasound can be used for screening and, if necessary, CT renal angiography or DSA to assess renal artery stenosis.
Although there have been no large-scale prospective or retrospective studies in patients with moyamoya disease combined with renovascular hypertension, this remains an interesting topic. Whether there is an association between phenotype and renovascular hypertension in patients with moyamoya disease and how this association occurs needs to be further revealed. In the future, it may help reveal the genetic pattern of moyamoya disease, optimize the treatment for patients with moyamoya disease, and even provide a reference for predicting the occurrence of moyamoya disease in advance.
Author contributions
EL, HZ, CL, XT, CL contributed equally to this work. All authors contributed to the article and approved the submitted version
Funding
Supported by Joint Project of Yunnan Science and Technology Department and Kunming Medical University (Grant No. 2019FE001(-160)), Yunnan Fundamental Research Projects (Grant No. 202201AT070014), Open Project of the Clinical Medical Center of the First People’s Hospital of Yunnan Province (Grant No. 2021LCZXXF-SJ04, 2022LCZXKF-SJ03)
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note
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Keywords: moyamoya disease (MMD), renovascular hypertension, RNF213 gene, children, renal artery stenosis (RAS)
Citation: Liu E, Zhao H, Liu C, Tan X, Luo C and Yang S (2022) Research progress of moyamoya disease combined with renovascular hypertension. Front. Surg. 9:969090. doi: 10.3389/fsurg.2022.969090
Received: 14 June 2022; Accepted: 10 August 2022;
Published: 26 August 2022.
Edited by:
Marcos Devanir S. Da Costa, Universidade Federal de Sao Paulo, BrazilReviewed by:
Daniel Cardeal, University of São Paulo, Brazil© 2022 Liu, Zhao, Liu, Tan, Luo and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Shuaifeng Yang eWFuZ3NodWFpZmVuZzdAMTYzLmNvbQ==
Specialty Section: This article was submitted to Neurosurgery, a section of the journal Frontiers in Surgery