AUTHOR=Wen Ze-Lin , Xiao Da-Chun , Zhou Xiong 

TITLE=Does Intraoperative Blood Loss Affect the Short-Term Outcomes and Prognosis of Gastric Cancer Patients After Gastrectomy? A Meta-Analysis

JOURNAL=Frontiers in Surgery

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2022.924444

DOI=10.3389/fsurg.2022.924444

ISSN=2296-875X

ABSTRACT=<sec><title>Purpose</title><p>The purpose of the current meta-analysis was to analyze whether intraoperative blood loss (IBL) influenced the complications and prognosis of gastric cancer patients after gastrectomy.</p></sec><sec><title>Methods</title><p>We systematically searched the PubMed, Embase and Cochrane library databases on November 29, 2021. The Newcastle-Ottawa scale was used to evaluate the quality of included studies. This meta-analysis uses RevMan 5.3 for data analysis.</p></sec><sec><title>Results</title><p>A total of nine retrospective studies were included in this meta-analysis, involving 4653 patients. In terms of short-term outcomes, the Larger IBL group has a higher complication rate (OR = 1.94, 95% CI, 1.44 to 2.61, <italic>P</italic> &lt; 0.0001) and a longer operation time (OR = 77.60, 95% CI, 41.95 to 113.25, <italic>P</italic> &lt; 0.0001) compared with the smaller IBL group, but the Larger IBL group had higher total retrieved lymph nodes (OR = 3.68, 95% CI, 1.13 to 6.24, <italic>P</italic> = 0.005). After pooling up all the HRs, the Larger IBL group has worse overall survival (OS) (HR = 1.80, 95% CI, 1.27 to 2.56, <italic>P</italic> = 0.001) and disease-free survival (DFS) (HR = 1.48, 95% CI, 1.28 to 1.72, <italic>P</italic> &lt; 0.00001).</p></sec><sec><title>Conclusion</title><p>Larger IBL increased operation time and postoperative complications, and decreased OS and DFS of gastric cancer patients. Therefore, surgeons should be cautious about IBL during operation.</p></sec>