AUTHOR=Zhang Zheng-Yun , Guan Jiao , Wang Xin-Ping , Hao Di-Si , Zhou Zun-Qiang 

TITLE=Analysis of lymph node spread and its prognostic significance in ampullary adenocarcinoma: A retrospective study

JOURNAL=Frontiers in Surgery

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2022.901615

DOI=10.3389/fsurg.2022.901615

ISSN=2296-875X

ABSTRACT=<sec><title>Background</title><p>Nodal status is a vital prognostic factor for ampullary adenocarcinoma. This study was designed to evaluate the clinical significance of the positive nodes in this disease.</p></sec><sec><title>Methods</title><p>Data from 110 patients who underwent curative pancreatoduodenectomy for ampullary adenocarcinoma between January 2007 and December 2018 were retrospectively collected and analyzed.</p></sec><sec><title>Results</title><p>The median number of lymph nodes per patient was 32 (20–46). Metastatic lymph nodes were found in 84 (76.4%) patients. In patients with positive nodules, the most commonly involved nodes were the #13 (80.1%) and #17 (78.6%) nodes, followed by #12 (69.0%) and #8 nodes (57.1%). Patients with 3–4 positive nodes among #13, #17, #12, and #8 had lower survival rates than those with 0 or 1–2 nodes.</p></sec><sec><title>Conclusion</title><p>Ampullary adenocarcinoma commonly spreads to #13, #17, #12, and #8 lymph nodes. These nodes affected the patients' survival rates dramatically.</p></sec>