AUTHOR=Guo Meiling , Li Yanjie , Wang Wentao , Kang Xu , Chen Guiyun 

TITLE=Variation of Anxiety and Depression During a 3-Year Period as Well as Their Risk Factors and Prognostic Value in Postoperative Bladder Cancer Patients

JOURNAL=Frontiers in Surgery

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2022.893249

DOI=10.3389/fsurg.2022.893249

ISSN=2296-875X

ABSTRACT=<sec><title>Background</title><p>Anxiety and depression are commonly recognized and prognostically relevant in cancer patients. The aim of this study was to explore the 3-year longitudinal changes in anxiety and depression, their risk factors, and prognostic value in patients with bladder cancer.</p></sec><sec><title>Methods</title><p>Hospital Anxiety and Depression Scale for anxiety (HADS-A) and depression (HADS-D) scores of 120 postoperative bladder cancer patients and 100 healthy controls (HCs) were assessed. Additionally, the HADS-A and HADS-D scores of bladder cancer patients were determined at 1 year, 2 years, and 3 years post surgery.</p></sec><sec><title>Results</title><p>HADS-A score (7.7 ± 3.0 vs. 4.8 ± 2.6), anxiety rate (38.3% vs. 9.0%), HADS-D score (7.7 ± 3.3 vs. 4.3 ± 2.6), depression rate (40.0% vs. 11.0%), as well as anxiety degree and depression degree, were all increased in bladder cancer patients compared with HCs (all <italic>P </italic>&lt; 0.001). Besides, the HADS-A score gradually increased from baseline to 3 years (<italic>P </italic>= 0.004), while the anxiety rate, HADS-D score, and depression rate did not change significantly (all <italic>P </italic>&gt; 0.050). Gender, tumor size, marriage status, hypertension, diversity, and lymph node (LN) metastasis were associated with anxiety or depression in patients with bladder cancer (all <italic>P </italic>&lt; 0.050). Anxiety was associated with shortened overall survival (OS) (<italic>P </italic>= 0.024) but did not link with disease-free survival (DFS) (<italic>P </italic>= 0.201); depression was not correlated with either DFS or OS (both <italic>P </italic>&gt; 0.050).</p></sec><sec><title>Conclusion</title><p>The prevalence and severity of anxiety and depression are high in patients with bladder cancer, which are influenced by gender, tumor features, marriage status, and hypertension; in addition, their correlation with survival is relatively weak.</p></sec>