AUTHOR=Yang Hua , Liu Yongjun 

TITLE=RETRACTED: Kinesin Family Member 2A Serves as a Potential Biomarker Reflecting More Frequent Lymph Node Metastasis and Tumor Recurrence Risk in Basal-Like Breast Cancer Patients

JOURNAL=Frontiers in Surgery

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2022.889294

DOI=10.3389/fsurg.2022.889294

ISSN=2296-875X

ABSTRACT=<sec><title>Background</title><p>Kinesin family member 2A (KIF2A) is reported as an oncogene and a potential biomarker for progression and prognosis in several cancers such as cervical, ovarian, and gastric. However, its clinical value in basal-like breast cancer (BLBC) is unclear. This study aims to evaluate KIF2A expression and its correlation with clinical features and survival rates in BLBC patients.</p></sec><sec><title>Methods</title><p>KIF2A mRNA and protein expressions in tumor and adjacent tissues from 89 BLBC patients are assessed by reverse transcription-quantitative polymerase chain reaction and immunohistochemistry assays, respectively.</p></sec><sec><title>Results</title><p>Both KIF2A protein (<italic>p </italic>&lt; 0.001) and mRNA expressions (<italic>p </italic>&lt; 0.001) were higher in tumor than in adjacent tissue. Besides, tumor KIF2A protein expression was positively correlated with N (<italic>p </italic>= 0.028) and TNM (<italic>p </italic>= 0.014) stages; meanwhile, tumor KIF2A mRNA expression was positively correlated with N stage (<italic>p </italic>= 0.046), TNM stage (<italic>p </italic>= 0.006), and tumor size (<italic>p </italic>= 0.043). Additionally, both tumor KIF2A protein (<italic>p </italic>= 0.035) and mRNA (<italic>p </italic>= 0.039) high expressions were correlated with worse disease-free survival (DFS) but not with overall survival (both <italic>p </italic>&gt; 0.05). Moreover, tumor KIF2A protein expression was higher in relapsed patients than in non-relapsed patients within 3 years (<italic>p </italic>= 0.015) and 5 years (<italic>p </italic>= 0.031), whereas no difference was found between the dead and survivors within 3 years (<italic>p </italic>= 0.057) or 5 years (<italic>p </italic>= 0.107). Lastly, after adjustment, tumor KIF2A mRNA high exhibited a trend that correlated with DFS but without statistical significance (<italic>p </italic>= 0.051).</p></sec><sec><title>Conclusion</title><p>KIF2A correlates with more frequent lymph node metastasis and worse DFS in BLBC patients, shedding light on its potency as a biomarker for BLBC.</p></sec>