Yu-Hsien Lin1†
Jun-Sing Wang2,3,4,5†
Wen-Chien Wang1†
Yu-Tsung Lin1Yun-Che Wu1Kun-Hui Chen1,5,6Chien-Chou Pan1,7Ning-Chien Chin1Cheng-Min Shih1,5,8
Cheng-Hung Lee1,5,9*- 1Department of Orthopedics, Taichung Veterans General Hospital, Taichung, Taiwan
- 2Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- 3Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- 4Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan
- 5College of Medicine, National Chung Hsing University, Taichung, Taiwan
- 6Department of Computer Science and Information Engineering, Providence University, Taichung, Taiwan
- 7Department of Rehabilitation Science, Jenteh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan
- 8Department of Physical Therapy, Hung Kuang University, Taichung, Taiwan
- 9Department of Food Science and Technology, Hung Kuang University, Taichung, Taiwan
Aim: Limited data are available on the impact of the coronavirus disease 2019 (COVID-19) pandemic on patient-reported outcome measures (PROMs) in patients who underwent spine surgery. In this study, we aimed to investigate the associations between the COVID-19 outbreak in Taiwan (May 2021) and PROMs in patients who underwent spine surgery.
Method: We retrospectively identified patients who underwent spine surgery during identical defined 6-week time-intervals (May 16 to June 30) in 2019, 2020, and 2021. PROMs, including visual analog scale (VAS) score for pain, Oswestry disability index (ODI), and EuroQol-5D (EQ-5D), were investigated before surgical intervention and at a 1-month follow-up. Relevant clinical information was collected from the electronic medical records of patients. Linear regression analysis was used to examine the association between the pandemic in 2021 (vs. 2019/2020) and the PROMs after adjusting for age, sex, and relevant clinical variables.
Results: The number of patients who underwent spine surgery at our hospital during the identical defined 6-week time-intervals in 2019, 2020, and 2021 was 77, 70, and 48, respectively. The surgical intervention significantly improved VAS, ODI, and EQ-5D of the patients (1 month after surgery vs. before surgery, all p < 0.001) in all three study periods. However, there was a significant between-group difference in change from baseline in VAS (p = 0.002) and EQ-5D (p = 0.010). The decrease in VAS and increase in EQ-5D after surgery in 2021 were not as much as those in 2019 and 2020. The associations between the pandemic in 2021 (vs. 2019/2020) and changes in VAS (β coefficient 1.239; 95% confidence interval [CI] 0.355 to 2.124; p = 0.006) and EQ-5D (β coefficient, −0.095; 95% CI, −0.155 to −0.035; p = 0.002) after spine surgery were independent of relevant clinical factors.
Conclusion: There was less improvement in short-term PROMs (VAS and EQ-5D) after spine surgery during the COVID-19 pandemic. Assessment of PROMs in surgical patients during a pandemic may be clinically relevant, and psychological support in this condition might help improve patients' outcomes.
Introduction
Since the coronavirus disease 2019 (COVID-19) pandemic (1), the health care system worldwide has encountered a huge challenge. The large patient volume, shortage of medical staff, and imperative quarantine and lockdown changed daily medical practice and health care quality (2, 3). For example, an increase in body weight and body mass index during the pandemic may be associated with an increased incidence of cardiovascular risk factors and subsequent risk of cardiovascular diseases (4, 5).
Similar conditions have also been seen in surgeries (6). The impact of the pandemic on surgical volume may lead to postponement of elective surgeries (7–9), which may have unfavorable effects on patient outcomes (10). In fact, a recent global survey (11) showed that hip fracture service was disrupted during the pandemic, thereby impacting health and social care experienced by the patients. This dilemma was also noted in cardiovascular (12), gastrointestinal, and (13) oncology (14) surgeries.
Moreover, the aforementioned issues may have negative effects on patients' psychosocial function (15). Patient-reported outcome measures (PROMs) are important assessment of quality in spine surgery (16). However, there are limited data on the impact of the COVID-19 pandemic on PROMs in patients who underwent spine surgery. Furthermore, a COVID-19 outbreak occurred in Taiwan in May 2021. This study aimed to investigate the associations between the COVID-19 outbreak in Taiwan and PROMs in patients who underwent spine surgery.
Methods
We hypothesized that a pandemic may have an impact on PROMs in patients undergoing spine surgery. A level 3 outbreak alert for COVID-19 was announced by the Taiwan Center of Disease Control on May 15, 2021. We conducted a retrospective study to investigate the changes in PROMs after spine surgery before and after the level 3 outbreak in Taiwan. A total of 13,329 patients had confirmed COVID-19 in Taiwan between May 16, 2021, and June 30, 2021 (only 7 patients had confirmed COVID-19 during the same time frame in 2020). Hence, we retrospectively identified patients who underwent spine surgery in our hospital during identical defined 6-week time-intervals (May 16 to June 30) in 2019, 2020, and 2021. Several measures of perioperative and postoperative quality of care, as well as PROMs in the three study periods, were investigated. This study was conducted following the Declaration of Helsinki. The study protocol was approved by the Institutional Review Board of Taichung Veterans General Hospital, Taichung, Taiwan (approval number: CE21395B).
We included adult patients who were admitted for spine surgery during the study period. Several PROMs, including visual analog scale (VAS) for pain (17), Oswestry disability index (ODI) (18), and EuroQol-5D (EQ-5D) (19), were investigated before surgical intervention and at 1-month follow-up. Patients who had missing information on the PORMs were excluded. Assessment of PROMs was conducted by a trained nurse as part of pre-operative evaluation. The assessment was conducted again 1 month after the surgery at outpatient clinic or by phone calls. A higher VAS or ODI score indicates greater severity of pain and disability, respectively. The EQ-5D consists of assessment for health states in five dimensions (16)—mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. The original scores of the five dimensions were transformed to a final score. A higher value indicates a better quality of life.
Relevant clinical information was collected from the electronic medical records of patients. The indication for surgery was clarified and classified as trauma of spine, degeneration/deformity of spine, and infection/neoplasm/others. The followings were considered as an emergency diagnosis: compression fracture, burst fracture/fracture-dislocation, tumor/metastasis, cauda equina syndrome/myelopathy/motor weakness, and infection. The level of spine surgery, presence of spinal cord injury, type of procedure, duration of surgery, intraoperative blood loss, neurological complications, and unplanned surgical revision were recorded. Measures of perioperative quality of care included waiting days from outpatient clinic to admission for surgery, waiting hours from the emergency department visit to the surgery, and length of hospital stay. Measures of postoperative quality of care included outpatient clinic follow-up rate and emergency department visit within 3 days or readmission within 14 days after hospital discharge.
Statistical Analysis
Statistical analyses were performed using the Statistical Package for the Social Sciences (IBM SPSS version 22.0; International Business Machines Corp, NY, USA). Changes from baseline to 1-month follow-up in the PROMs were compared using the Wilcoxon signed-rank test. Statistical differences in the variables across the three study time frames were examined using the Kruskal–Wallis test. The associations between the pandemic in 2021 (vs. 2019/2020) and the PROMs after adjustment for age, sex, and relevant clinical variables were examined using linear regression analysis. A p-value of <0.05 was considered statistically significant in all analyses.
Results
The number of patients who underwent spine surgery at our hospital during the identical defined 6-week time-intervals in 2019, 2020, and 2021 was 77, 70, and 48, respectively (Table 1). There was a trend toward a decrease in surgical volume in 2021 (6.9 ± 2.7 operations per week), compared to that in 2019 (11.0 ± 2.6 operations per week) and 2020 (10.0 ± 5.0 operations per week) (p = 0.069). A higher proportion of patients who underwent spine surgery in 2021 had diabetes (37.5%) compared to the number of patients who underwent spine surgery in 2019 (16.9%) and 2020 (15.7%) (p = 0.008). There were no significant between-group differences in the other variables (Table 1). Surgical procedures and complications are presented in Table 2. There were no significant between-group differences in these variables.
Table 1. Characteristics of the study population according to the year of surgery.
Table 2. Surgical procedures and complications of the study population according to the year of surgery.
Parameters related to the quality of care are summarized in Table 3. Across the three study time frames, there were no significant differences in the time from outpatient/emergency department visit to admission/surgery and length of hospital stay. The surgical intervention significantly improved VAS, ODI, and EQ-5D (1 month after surgery vs. before surgery, all p < 0.001) in 2019, 2020, and 2021. Nevertheless, there was a significant between-group difference in change from baseline in VAS (p = 0.002) and EQ-5D (p = 0.010). The decrease in VAS and increase in EQ-5D after surgery in 2021 were not as much as those in 2019 and 2020. The time interval between hospital discharge and outpatient clinic follow-up was longer in 2021, compared with that in 2019 and 2020. However, there were no significant differences in the rate of outpatient clinic follow-up, emergency department visit within 3 days after hospital discharge, and readmission within 14 days after hospital discharge between the three study time frames (Table 3).
Table 3. Parameters related to quality of care according to the year of surgery.
Table 4 shows the original scores of the five dimensions of EQ-5D before and 1 month after surgery in the three study periods. There were no significant between-group differences regarding the changes from baseline to 1-month follow-up in scores for mobility, self-care, and usual activities. The improvement (1 month after surgery vs. before surgery) in pain/discomfort and anxiety/depression was significant (p < 0.001) in 2019, 2020, and 2021. Similar to the findings in Table 3, the decrease in pain/discomfort (p = 0.001) and anxiety/depression (p < 0.001) after surgery in 2021 was not as much as that in 2019 and 2020.
Table 4. Original scores of the five dimensions of EQ-5D according to the year of surgery.
The associations between the pandemic in 2021 (vs. 2019/2020) and changes from baseline in VAS and EQ-5D after spine surgery are shown in Table 5. There was a positive association between surgery in 2021 (vs. 2019/2020) and change from baseline in VAS (β coefficient 1.563; 95% confidence interval [CI] 0.700 to 2.427; p < 0.001; Model 1). The association remained significant (β coefficient, 1.239; 95% CI, 0.355 to 2.124; p = 0.006; Model 4) after adjustment for age, sex, and relevant clinical variables. Similarly, there was a negative association between surgery in 2021 (vs. 2019/2020) and change from baseline in EQ-5D (β coefficient −0.086; 95% CI −0.147 to −0.025; p = 0.006; Model 1). The association was independent of other relevant clinical variables (β coefficient, −0.095; 95% CI, −0.155 to −0.035; p = 0.002; Model 4).
Table 5. Associations between the COVID-19 pandemic in 2021 and changes from baseline to 1-month follow-up in VAS and EQ-5D scores.
Discussion
In this study, we reported that the decrease in VAS and increase in EQ-5D after spine surgery in 2021 were not as much as those in 2019 and 2020. We demonstrated independent associations between spinal surgery in 2021 (vs. 2019/2020) and changes in VAS and EQ-5D in the COVID-19 pandemic period in Taiwan. To the best of our knowledge, this is the first study to investigate the association between the COVID-19 pandemic and PROMs after spine surgery.
Clinical practices have changed since 2020 and affected numerous branches of medicine such as surgery (20). Studies have reported a decrease in surgical volume and the postponement of surgical procedures (21). These factors may increase psychological stress in surgical patients during the pandemic period (22–24). Moreover, psychological stress may affect PROMs after orthopedic surgery (25–27). These findings may explain why patients showed less improvement in VAS and EQ-5D after spinal surgery during the pandemic (Table 3). The associations between the pandemic in Taiwan (2021 vs. 2019/2020) and PROMs were independent of several confounders (Table 5). This was further supported by the finding that patients showed less improvement in the dimension of anxiety/depression during the pandemic (Table 4).
There were no significant differences in the waiting time from outpatient clinic visit to admission for surgery, the time from emergency department visit to the surgery, and length of hospital stay across the three study periods (Table 3). Despite the prolonged time from hospital discharge to outpatient clinic follow-up, there were no significant differences in terms of the postoperative outpatient clinic follow-up rate and unscheduled emergency department visit within 3 days or readmission within 14 days after hospital discharge. A higher proportion of our patients in 2021 had diabetes (Table 1). This finding might be explained by that patients with diabetes were considered as a priority for surgery when the surgical volume was affected by the pandemic. None of the patients had COVID-19 during the study period. These findings revealed the efforts undertaken to support the quality of surgical care during the pandemic. Minor surgery was considered safe during the COVID-19 pandemic in a recent report (28). Although half of the patients in this study had an emergency diagnosis (Table 1), the surgical procedures were safely conducted during the pandemic with objective measures of quality of care similar to those in the previous 2 years.
Since limited studies have investigated the effect of the pandemic on PROMs of surgical procedures, our findings are clinically relevant as important PROMs associated with surgical complications (16, 29, 30) are occasionally overlooked in clinical practice. The significant associations between spinal surgery during the pandemic period and changes in PROMs (VAS and EQ-5D) highlight the importance of psychological support in medical and surgical care during the COVID-19 period (31, 32).
There are several limitations to this study. First, this was a retrospective study conducted at a single center with relatively small sample size. Further large-scale prospective studies in patients who underwent orthopedic surgery are needed to validate the findings of this study. Second, the PROMs were assessed before and 1 month after surgery. The effects of a pandemic on long-term outcomes in patients who underwent spine surgery warrant further investigation. With these limitations in mind, the findings provided insights on surgical care for patients who underwent spine surgery during a pandemic.
Conclusion
We demonstrated less improvement in short-term PROMs (VAS and EQ-5D) after spine surgery during the pandemic in Taiwan. The associations between the pandemic and improvements in PROMs were independent of several confounders. Assessment of PROMs in surgical patients during a pandemic may be clinically relevant, and psychological support in this condition might help improve patients' outcomes. Further studies are needed to confirm these findings.
Data Availability Statement
The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author/s.
Author Contributions
Y-HL, J-SW, and C-HL designed and conducted the research. Y-HL, W-CW, Y-TL, Y-CW, K-HC, C-CP, N-CC, and C-MS contributed acquisition of data, analysis, and interpretation of data. Y-HL, J-SW, and W-CW wrote the first draft of the manuscript. Y-TL, Y-CW, K-HC, C-CP, N-CC, C-MS, and C-HL revised the manuscript critically for important intellectual content. All authors approved the final draft of the manuscript.
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's Note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Acknowledgments
The authors would like to thank the Biostatistics Task Force of Taichung Veterans General Hospital and Mr. Chen Jun-Peng for statistical analysis.
References
1. Rasmussen SA, Jamieson DJ. Public health decision making during COVID-19—fulfilling the CDC pledge to the American people. N Engl J Med. (2020) 383:901–3. doi: 10.1056/NEJMp2026045
2. Li X, Krumholz HM, Yip W, Cheng KK, De Maeseneer J, Meng Q, et al. Quality of primary health care in China: challenges and recommendations. Lancet. (2020) 395:1802–12. doi: 10.1016/S0140-6736(20)30122-7
3. Keesara S, Jonas A, Schulman K. Covid-19 and health care's digital revolution. N Engl J Med. (2020) 382:e82. doi: 10.1056/NEJMp2005835
4. Bakaloudi DR, Barazzoni R, Bischoff SC, Breda J, Wickramasinghe K, Chourdakis M. Impact of the first COVID-19 lockdown on body weight: a combined systematic review and a meta-analysis. Clin Nutr. (2021) S0261-5614(21)00207-7. doi: 10.1016/j.clnu.2021.04.015 [Epub ahead of Print].
5. Cava E, Neri B, Carbonelli MG, Riso S, Carbone S. Obesity pandemic during COVID-19 outbreak: narrative review and future considerations. Clin Nutr. (2021) 40:1637–43. doi: 10.1016/j.clnu.2021.02.038
6. De la Cerda-Vargas MF, Stienen MN, Soriano-Sánchez JA, Campero Á, Borba LAB, Nettel-Rueda B, et al. Impact of the coronavirus disease 2019 pandemic on working and training conditions of neurosurgery residents in Latin America and Spain. World Neurosurg. (2021) 150:e182–202. doi: 10.1016/j.wneu.2021.02.137
7. Czubak-Wrzosek M, Czubak J, Grzelecki D, Tyrakowski M. The effect of the covid-19 pandemic on total hip and knee arthroplasty surgical volume in 2020 in Poland. Int J Environ Res Public Health. (2021) 18:8830. doi: 10.3390/ijerph18168830
8. Norris ZA, Sissman E, O'Connell BK, Mottole NA, Patel H, Balouch E et al. COVID-19 pandemic and elective spinal surgery cancelations - what happens to the patients? Spine J. (2021) 21:2003–9. doi: 10.1016/j.spinee.2021.07.019
9. Bajunaid K, Alatar A, Alqurashi A, Alkutbi M, Alzahrani AH, Sabbagh AJ, et al. The longitudinal impact of COVID-19 pandemic on neurosurgical practice. Clin Neurol Neurosurg. (2020) 198:106237. doi: 10.1016/j.clineuro.2020.106237
10. Fehlings MG, Vaccaro A, Wilson JR, Singh A, W Cadotte DW, Harrop JS, et al. Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS). PLoS ONE. (2012) 7:e32037. doi: 10.1371/journal.pone.0032037
11. Hall AJ, Clement ND, MacLullich AMJ, Ojeda-Thies C, Hoefer C, Brent L, et al. Impact of COVID-19 on hip fracture services: a global survey by the International Multicentre Project Auditing COVID-19 in Trauma & orthopaedics. Surgeon. (2021) S1479-666X(21)00092-5. doi: 10.1016/j.surge.2021.04.007 [Epub ahead of Print].
12. Shah SMI, Bin Zafar MD, Yasmin F, Ghazi EM, Jatoi HN, Jawed A, et al. Exploring the impact of the COVID-19 pandemic on cardiac surgical services: a scoping review. J Card Surg. (2021) 36:3354–63. doi: 10.1111/jocs.15746
13. Gupta R, Gupta J, Ammar H. Impact of COVID-19 on the outcomes of gastrointestinal surgery. Clin J Gastroenterol. (2021) 14:932–46. doi: 10.1007/s12328-021-01424-4
14. Bernstein AN, Talwar R, Handorf E, Syed K, Danella J, Ginzburg S et al. Assessment of prostate cancer treatment among black and white patients during the COVID-19 pandemic. JAMA Oncol. (2021) 7:1467–73. doi: 10.1001/jamaoncol.2021.2755
15. Micoogullari U, Kisa E, Yucel C, Ozbilen MH, Karaca E, Cakici MC, et al. The effect of the first wave of COVID-19 pandemic on urology practice and anxiety scores of patients awaiting surgery. Int J Clin Pract. (2021) 75:e14201. doi: 10.1111/ijcp.14201
16. McCormick JD, Werner BC, Shimer AL. Patient-reported outcome measures in spine surgery. J Am Acad Orthop Surg. (2013) 21:99–107. doi: 10.5435/JAAOS-21-02-99
17. Jensen MP, Karoly P, Braver S. The measurement of clinical pain intensity: a comparison of six methods. Pain. (1986) 27:117–26. doi: 10.1016/0304-3959(86)90228-9
18. Fairbank JC, Couper J, Davies JB, O'Brien JP. The Oswestry low back pain disability questionnaire. Physiotherapy. (1980) 66:271–3. doi: 10.1037/t04205-000
19. Tsuchiya A, Ikeda S, Ikegami N, Nishimura S, Sakai I, Fukuda T, et al. Estimating an EQ-5D population value set: the case of Japan. Health Econ. (2002) 11:341–53. doi: 10.1002/hec.673
20. Ow ZGW, Cheong CK, Chin YH, Chin BZ. A look at the global impact of SARS CoV-2 on orthopedic services. J Clin Orthop Trauma. (2021) 12:33–9. doi: 10.1016/j.jcot.2020.10.052
21. Mehta AI, Chiu RG. COVID-19 nonessential surgery restrictions and spine surgery: a German experience. Spine. (2020) 45:942–3. doi: 10.1097/BRS.0000000000003571
22. Zieger M, Schwarz R, König HH, Härter M, Riedel-Heller SG. Depression and anxiety in patients undergoing herniated disc surgery: relevant but underresearched—a systematic review. Cent Eur Neurosurg. (2010) 71:26–34. doi: 10.1055/s-0029-1225325
23. Doglietto F, Vezzoli M, Biroli A, Saraceno G, Zanin L, Pertichetti M, et al. Anxiety in neurosurgical patients undergoing nonurgent surgery during the COVID-19 pandemic. Neurosurg Focus. (2020) 49:E19. doi: 10.3171/2020.9.FOCUS20681
24. Zheng Y, Zhang X, Fang S, Zhang F. The distribution and psychological distress related to COVID-19 of spine patients in a Grade-A tertiary hospital in Anhui Province, China. Sci Prog. (2021) 104:368504211010571. doi: 10.1177/00368504211010571 [Epub ahead of Print].
25. Flanigan DC, Everhart JS, Glassman AH. Psychological factors affecting rehabilitation and outcomes following elective orthopaedic surgery. J Am Acad Orthop Surg. (2015) 23:563–70. doi: 10.5435/JAAOS-D-14-00225
26. Filardo G, Merli G, Roffi A, Marcacci T, Berti Ceroni F, Raboni D, et al. Kinesiophobia and depression affect total knee arthroplasty outcome in a multivariate analysis of psychological and physical factors on 200 patients. Knee Surg Sports Traumatol Arthrosc. (2017) 25:3417–23. doi: 10.1007/s00167-016-4201-3
27. Sharma S, Kumar V, Sood M, Malhotra R. Effect of preoperative modifiable psychological and behavioural factors on early outcome following total knee arthroplasty in an Indian population. Indian J Orthop. (2021) 55:939–47. doi: 10.1007/s43465-020-00325-x
28. Baboudjian M, Mhatli M, Bourouina A, Gondran-Tellier B, Anastay V, Perez L, et al. Is minor surgery safe during the COVID-19 pandemic? A multi-disciplinary study. PLoS ONE. (2021) 16:e0251122. doi: 10.1371/journal.pone.0251122
29. Guzman JZ, Cutler HS, Connolly J, Skovrlj B, Mroz TE, Riew KD, et al. Patient-reported outcome instruments in spine surgery. Spine. (2016) 41:429–37. doi: 10.1097/BRS.0000000000001211
30. Khatib Y, Badge H, Xuan W, Naylor JM, Harris IA. Patient satisfaction and perception of success after total knee arthroplasty are more strongly associated with patient factors and complications than surgical or anaesthetic factors. Knee Surg Sports Traumatol Arthrosc. (2020) 28:3156–63. doi: 10.1007/s00167-019-05804-9
31. Dubey S, Biswas P, Ghosh R, Chatterjee S, Dubey MJ, Chatterjee S, et al. Psychosocial impact of COVID-19. Diabetes Metab Syndr. (2020) 14:779–88. doi: 10.1016/j.dsx.2020.05.035
Keywords: coronavirus disease 2019, health care quality, pandemic, patient report outcome, spine surgery
Citation: Lin Y-H, Wang J-S, Wang W-C, Lin Y-T, Wu Y-C, Chen K-H, Pan C-C, Chin N-C, Shih C-M and Lee C-H (2022) The Impact of COVID-19 Surges in 2019–2021 on Patient-Reported Outcome Measures After Spine Surgery at an Academic Tertiary Referral Center in Taiwan: A Retrospective Observational Cohort Study. Front. Surg. 9:853441. doi: 10.3389/fsurg.2022.853441
Received: 12 January 2022; Accepted: 15 February 2022;
Published: 17 March 2022.
Edited by:
Sebastian Weckbach, Ulm University Medical Center, GermanyReviewed by:
Philip Frank Stahel, Rocky Vista University, United StatesRizaldy Taslim Pinzon, Duta Wacana Christian University, Indonesia
Copyright © 2022 Lin, Wang, Wang, Lin, Wu, Chen, Pan, Chin, Shih and Lee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Cheng-Hung Lee, Mjk4ZiYjeDAwMDQwO3ZnaHRjLmdvdi50dw==
†These authors have contributed equally to this work and share first authorship