AUTHOR=Geng Xiaoyuan , Zhou Shangyou , Zhang Xiaoyan , Liu Xi , Cheng Xu , Jiang Lihua , Zhang Donghang 

TITLE=The Efficacy and Safety of Celecoxib for Pain Management After Total Knee Arthroplasty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

JOURNAL=Frontiers in Surgery

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2022.791513

DOI=10.3389/fsurg.2022.791513

ISSN=2296-875X

ABSTRACT=<sec><title>Background</title><p>This study aimed to determine the efficacy and safety of celecoxib for pain management after total knee arthroplasty (TKA).</p></sec><sec><title>Methods</title><p>PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched to identify eligible randomized controlled trials (RCTs) that compared celecoxib with a placebo in term of pain control efficacy after TKA. Primary outcomes included pain scores at 24, 48, and 72 h after TKA. Secondary outcomes included the active range of motion (ROM) at 24, 48,72 h, and 7 days postoperatively, morphine consumption over 72 h after TKA, incidence of postoperative nausea and vomiting (PONV), and total blood loss after surgery. Data analysis was conducted using RevMan version 5.3.</p></sec><sec><title>Results</title><p>Five RCTs involving 593 participants were included in the study. Compared with a placebo, celecoxib significantly reduced visual analog scale (VAS) scores at rest at 24 h [mean difference (MD) = −0.72; 95% confidence interval (CI), −1.27 to −0.17; <italic>I</italic><sup>2</sup> = 82%; <italic>P</italic> = 0.01], 48 h (MD = −1.51; 95% CI, −2.07 to −0.95; <italic>I</italic><sup>2</sup> = 0%; <italic>P</italic> &lt; 0.00001), and 72 h (MD = −1.30; 95% CI, −2.07 to −0.54; <italic>I</italic><sup>2</sup> = 82%; <italic>P</italic> = 0.0009) after TKA, decreased morphine consumption over postoperative 72 h (MD = −0.73; 95% CI, −0.96 to −0.51; <italic>I</italic><sup>2</sup> = 96%; <italic>P</italic> &lt; 0.00001), and increased active ROM at 48 h (MD = 13.23; 95% CI, 7.79 to 18.67; <italic>I</italic><sup>2</sup> = 0%; <italic>P</italic> &lt; 0.00001), 72 h (MD = 6.52; 95% CI, 4.95 to 8.10; <italic>I</italic><sup>2</sup> = 68%; <italic>P</italic> &lt; 0.00001), and 7 days (MD = 7.98; 95% CI, 3.64 to 12.31; <italic>I</italic><sup>2</sup> = 68%; <italic>P</italic> = 0.0003) after the operation. No significant difference was found in the active ROM at 24 h (MD = 7.60; 95% CI, −6.14 to 21.34; <italic>I</italic><sup>2</sup> = 94%; <italic>P</italic> = 0.28) and the incidence of PONV after surgery [risk ratio (RR) = 0.66; 95% CI, 0.40 to 1.09; <italic>I</italic><sup>2</sup> = 0%; <italic>P</italic> = 0.11].</p></sec><sec><title>Conclusion</title><p>The administration of celecoxib is an effective and safe strategy for postoperative analgesia after TKA.</p></sec>