AUTHOR=Huang Yihong , Chen Yu , Zhu Yan , Wu Qing , Yao Chengyun , Xia Hongping , Li Congzhu 

TITLE=Postoperative Systemic Immune-Inflammation Index (SII): A Superior Prognostic Factor of Endometrial Cancer

JOURNAL=Frontiers in Surgery

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2021.704235

DOI=10.3389/fsurg.2021.704235

ISSN=2296-875X

ABSTRACT=<p><bold>Objective:</bold> This study evaluates the preoperative and postoperative systemic immune-inflammation index (SII) capacity to predict the prognosis of patients with endometrial carcinoma after the operation and build a nomogram model to assist clinical practice.</p><p><bold>Methods:</bold> The retrospective study included 362 consecutive patients with surgically resected endometrial cancer between January 2010 and June 2015 at The Affiliated Cancer Hospital of Shantou University Medical College. Blood routine was examined within 1 week before surgery to calculate SII, NLR, PLR, and MLR and 3 days after surgery to measure SII. The Pearson's χ<sup>2</sup>-test or Fisher's exact test was used to explore their relationship to clinical variables. The univariate and multivariate survival analyses were performed by Cox regression to identify the independent prognostic indicators. The Kaplan–Meier method with the log-rank test was used to generate the overall survival (OS) curves. R software was used to generate the receiver operating characteristic (ROC) curve and then it got the optimum cutoff value through the maximum Youden index. A nomogram model was formed with systemic immune inflammation and clinical factors.</p><p><bold>Results:</bold> The preoperative SII was related to age (<italic>p</italic> = 0.009), FIGO stage (<italic>p</italic> = 0.02) and menopause (<italic>p</italic> = 0.014). The postoperative SII was associated with menopause (<italic>p</italic> = 0.014). Univariate analysis indicated that FIGO stage, lymphatic invasion, depth of myometrial invasion, postoperative chemotherapy, postoperative radiotherapy, preoperative SII, NLR, PLR, MLR, CRP, CA125, and postoperative SII were predictors of OS (<italic>p</italic> &lt; 0.05). Multivariate analysis showed that lymphatic invasion and postoperative SII were independent prognostic factors of OS (<italic>p</italic> &lt; 0.05). The nomogram model was visualized precisely to reflect the prognosis with a C-index value of 0.866 in this model.</p><p><bold>Conclusion:</bold> The postoperative SII is the independent prognostic factor in patients with endometrial carcinoma after the operation and contributes to poor outcomes. However, after surgery, the preoperative SII and preoperative NLR, PLR, and MLR are not associated with OS endometrial carcinoma. Making good use of the nomogram model would contribute to better subsequent therapy.</p>