AUTHOR=Tian Peng , Liu Yue , Li Zhi-jun , Xu Gui-jun , Ma Xin-long 

TITLE=Zoledronic Acid in Osteoporotic Vertebral Compression Fractures Treated With Percutaneous Kyphoplasty: A Meta-Analysis

JOURNAL=Frontiers in Surgery

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2021.668551

DOI=10.3389/fsurg.2021.668551

ISSN=2296-875X

ABSTRACT=<p><bold>Background:</bold> We performed a meta-analysis to evaluate the efficacy and safety of zoledronic acid combined with percutaneous kyphoplasty (PKP) in treating osteoporotic vertebral compression fractures (OVCFs).</p><p><bold>Methods:</bold> Eligible scientific articles published prior to July 2020 were retrieved from the PubMed, Springer, ScienceDirect, and Cochrane Library databases. The statistical analysis was performed with RevMan 5.1.</p><p><bold>Results:</bold> Three randomized controlled trials (RCTs) and 2 non-RCTs met the inclusion criteria. The present meta-analysis revealed that zoledronic acid combined with PKP is associated with a higher BMD, a better quality of life, less severe low back pain, and fewer additional vertebral body fractures than is percutaneous vertebral augmentation alone.</p><p><bold>Conclusions:</bold> Compared with PKP only, zoledronic acid combined with percutaneous vertebral augmentation is beneficial for OVCFs.</p>