Xiqian Wang1Liwei Peng1Haixing Guo2Juha Hernesniemi2Xuepeng Xiong3
Hugo Andrade-Barazarte2*Rongjun Qian2*- 1Department of Oral and Maxillofacial Surgery, Henan Provincial People's Hospital, Zhengzhou University, Henan University, Zhengzhou, China
- 2Department of Neurosurgery, Henan Provincial People's Hospital, Zhengzhou University, Henan University, Zhengzhou, China
- 3Department of Oral and Maxillofacial Head Neck Surgery, School & Hospital of Stomatology, Wuhan University, Wuhan, China
Background: Comprehensive knowledge of the internal jugular vein (IJV) regarding its anatomical variations and the pattern of its course is valuable for preventing unexpected injuries during surgical procedures or central venous access. IJV anatomical anomalies such as fenestration and duplication are rare, mainly represented by case reports, and intraoperative findings.
Objective: To present two additional cases of IJV anomalies and highlight its clinical presentation, anatomical characteristics, management, and prevalence through an extensive literature review.
Methods and Case Reports: From January 2017 to December 2018, we retrospectively collected data of 221 patients undergoing neck dissection (ND) procedures and identified two patients with IJV anomalies (fenestration and duplication) providing a clinical prevalence of ~0.9%. The IJV fenestration referred to an IJV bifurcation that reunites proximal to the subclavian vein, whereas in the IJV duplication both branches remain separated. In both of our cases, the spinal accessory nerve (SAN) crossed the window between the IJV branches.
Conclusion: Anatomical variations are more likely to be identified intraoperatively or incidentally, and due to the risk of SAN and vascular injury, special attention should be taken to identify them preoperatively in order to reduce the risk of iatrogenic injury and unexpected complications.
Introduction
Neck dissection (ND) or cervical lymphadenectomy is a frequent procedure performed in the management of patients with head and neck cancer (1). Radical ND is associated with severe comorbidities and post-operative complications (2, 3). Therefore, during the last decades, to improve outcome and quality of life, special attention has been paid to reduce complications and comorbidities during ND procedures by preserving the internal jugular vein (IJV) and/or the spinal accessory nerve (SAN) (2–4). Based on that, successful surgical management of patients undergoing ND depends on recognizing patient-specific anatomic structures that may increase their risk of an adverse outcome.
The internal jugular vein (IJV) besides being the largest vessel in the neck and head, represents a relevant surgical anatomical landmark for adjacent structures such as: the carotid artery, vagus nerve, SAN and cervical lymph nodes (5). The IJV can present certain anomalies such as: duplication (referring to a bifurcation of the vein with each branch having a separate connection to the subclavian vein) or either fenestration (which refers to a bifurcation that reunites proximal to the subclavian vein) (6, 7). Therefore, identifying these anatomical variations is useful to avoid unexpected surgical complications or during central venous catheterization.
Anatomical anomalies (duplication or fenestration) of the IJV are commonly underreported and its prevalence is limited to few case reports (8–12). Therefore, we present two additional cases and highlight its clinical presentation, anatomical characteristics, management, and prevalence through an extensive literature review.
Methods
Literature Review
We performed a PubMed search from 1986 to 2020 for articles in English on anatomical variations of the IVJ with the following keyword(s): human AND (anatomical variations) AND (anomalies) AND (internal jugular vein) AND (duplication) AND (fenestration). Furthermore, we scrutinized the bibliographies of the retrieved articles for additional references (Table 1).
Table 1. Literature review.
Study Cohort
From January 2017 to December 2018, we retrospectively reviewed a total of 221 patients who underwent ND due to oral malignancies, among them two patients showed IJV duplication or fenestration anomalies, with a clinical prevalence of ~0.9%.
Clinical Cases
Case 1
A 40-year-old woman presented with a lesion on the left margin of the tongue. Biopsy of this lesion showed a squamous cell carcinoma. The patient was clinically stage as T2N0M0 and underwent a left side partial resection of the tongue and suprascapulohyoid ND. Intraoperatively, the left IJV divided into two branches (anterior and posterior) after its cranial exit through the jugular foramen. This division continued distally for ~4 cm in length and both branches fused back together at the level of the central tendon of the digastric muscle (Figures 1A,B). Additionally, the SAN passed through the IJV fenestration. Before the fusion of the IJV branches, an anterior tributary was seen draining into the IJV from the anterolateral side of the platysma. The procedure went uneventful and without evidence of hemorrhages or SAN damage. Postoperative computed tomographic (CT) examination (Figure 1C) demonstrated the left IJV fenestration at the level of atlantoaxial intervertebral region in a retrospective view, suggesting that this anomaly could be clearly anticipated before performing a ND procedure.
Figure 1. (A) Intraoperative picture demonstrating a left-side neck dissection. The internal jugular vein divided into two branches anterior (A) and posterior (B) from its origin at the jugular foramen. Both branches run downwards parallel to each other for ~4 cm in length and fused back together (D), demonstrating a window-like opening between the two branches. The anterior branch of the internal jugular vein received blood from an anterior tributary vein (C). Additionally, the spinal accessory nerve transversed this fenestration (A, anterior branch internal jugular vein; B, posterior branch internal jugular vein; C, anterior tributary vein; SAN, spinal accessory nerve; D, internal jugular fusion after fenestration). (B) Intraoperative picture of a left-side neck dissection, demonstrating the course of the anterior tributary vein (C) running down on the anterolateral region and deep into the platysma (A, anterior branch internal jugular vein; B, posterior branch internal jugular vein; C, anterior tributary vein; SAN, spinal accessory nerve; D, internal jugular fusion after fenestration. (C) Three-dimensional computed tomographic angiography corroborating the intraoperative findings (A, anterior branch internal jugular vein; B, posterior branch internal jugular vein; C, anterior tributary vein; SAN, spinal accessory nerve; D, internal jugular fusion after fenestration).
Case 2
A 43-year-old woman who presented with a squamous cell carcinoma of the left mandibular gingiva. The patient was clinically staged as T2N0M0 and underwent a partial resection of the mandible and suprascapulohyoid ND. During the ND, the IJV divided into two branches (anterior and posterior) slightly above the mandibular angle and continued as two separate branches until the level of the omohyoid muscle. The spinal accessory nerve transversed the duplication from superficial to deep as it traveled toward the skull base (Figure 2). The perioperative course of the patient went uneventful and without evidence of hemorrhages or SAN damage.
Figure 2. Intraoperative picture of a left-side neck dissection, demonstrating the division of the internal jugular vein into two branches, remaining unfused along the neck area until the level of the omohyoid muscle. This finding represented an internal jugular vein duplication. Additionally, the spinal accessory nerve bisected the two branches (A, anterior branch internal jugular vein; B, posterior branch internal jugular vein; SAN, spinal accessory nerve).
Discussion
The major vasculature of the head and neck region is represented by the carotid arteries and the jugular veins. These vascular structures are frequently accessed by head and neck surgeons during prophylactic or therapeutic cervical lymphadenectomy, or either by anesthetists or intensivists while placing central venous catheters for central venous pressure monitoring, drug administration, or volume resuscitation. Therefore, it is important to identify anatomical anomalies to prevent unexpected complications. Here, we present two additional cases of IJV anatomical anomalies (fenestration and duplication), and highlight its clinical presentation, anatomical characteristics, management, and prevalence through an extensive literature review.
Prevalence
IJV duplications and fenestrations are rare, their prevalence has been calculated merely based on case reports and small case series (6–15, 18, 20–28, 30–33). Among them, Prades et al. (13) reported three cases of IJV (fenestration or duplication) malformations in 750 (French) ND cases, with a clinical prevalence of 0.4%. Moreover, Contrera et al. (26) demonstrated three cases of IJV fenestration among 295 cases of ND in the US, with a prevalence of 1% and Hashimoto et al. (7) identified four cases of IJV fenestration in 123 Japanese cases of ND, reporting a prevalence 3.33%. In our series of 221 Chinese patients undergoing ND procedures, the prevalence of IJV fenestration or duplication was 0.9%, which was in concordance with previously mentioned prevalence values.
Identification and Clinical Implication
IJV anatomical anomalies (fenestration and duplication) can be observed preoperatively by computed tomographic angiography (CTA) or during contrast enhancement CT imaging as part of clinical and radiological staging of patients (7, 12, 26, 34). As demonstrated by Towbin and Kanal, who reported two cases of IJV fenestration identified through CTA (33). Additionally, a non-invasive imaging technique such as doppler ultrasound has been used to identify these variations, although it is not widely practiced (29, 35). However, despite the ability to identify these anomalies through contrast-enhanced CT imaging, it is only mentioned in seldom cases, thus reflecting the lack of attention paid to the venous system in the setting of a pathologic adenopathy.
Additionally, similar to previous case reports, our IJV fenestration and duplication were evinced intraoperatively by direct visualization, which still represents the most common diagnostic method reported in the literature (32).
Moreover, it is important to mention that our two cases showed no symptoms related to their IJV anomalies, in concordance with previous reports (7, 26, 32). On the contrary, only very rare cases of IJV are symptomatic, among them the majority of patients present with neck swelling, and very seldom dysphagia or dyspnea (15, 20, 36, 37). Therefore, this subset of patients might be misdiagnosed with laryngoceles or branchial cleft cysts (20).
It is worth to mention, that in our two cases no difference existed regarding diameter of the IJV branches (anterior and posterior branches), and that the common carotid artery was located behind the posterior branch. Even though this aspect has not been discussed, previous reports showed no asymmetry in diameter of the IJV duplications/fenestration (6, 7, 12, 20).
Furthermore, knowing the different types of IJV anomalies could be beneficial to avoid: (1) Iatrogenic injury of the IJV, if a duplication or a fenestration is not appreciated and the IJV is partially controlled during a ND, therefore causing copious bleeding, which might be challenging to control due to the presence of multiple feeders. (2) Risk of injury of the SAN, since this nerve often passes through the fenestration or duplication of the IJV and it is associated to quality of life and outcome (4).
Ontogenesis
The etiology of IJV anomalies remains unclear. However, several hypotheses (vascular, neural, bony, and muscular) have been proposed in order to explain these anomalies (6, 26). In the vascular theory, the fenestration or duplication occurs due to inadequate condensation of the embryonic capillary plexus. Whereas, the neural theory suggests that branching of the IVJ is the result of obstructed growth by the SAN during development (which probably is consistent with cases of SAN bisecting the IJV). In the bony theory, aberrant ossifications or osteophytes could cause bony bridges responsible for venous partitioning. Finally, the muscular theory suggests the division of the IJV caused by the posterior belly of the omohyoid muscle (23).
Conclusion
IJV fenestration and duplications are rare. These anatomical variations are more likely to be identified intraoperatively or incidentally, and due to the risk of SAN and vascular injury, special attention should be taken to identify them preoperatively in order to reduce the risk of iatrogenic injury and unexpected complications.
Data Availability Statement
The original contributions presented in the study are included in the article/supplementary materials, further inquiries can be directed to the corresponding author/s.
Ethics Statement
Due to the retrospective nature of the study informed consent was waived.
Author Contributions
All authors contributed during the creation, data collection, preparation, editing, and revision of the following manuscript.
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Acknowledgments
We thank Christopher Ludtka for his valuable contribution and language revision.
References
1. Crile G. Landmark article Dec 1, 1906: excision of cancer of the head and neck. With special reference to the plan of dissection based on one hundred and thirty-two operations. By george crile. JAMA. (1987) 258:3286–93. doi: 10.1001/jama.258.22.3286
2. Calearo CV, Teatini G. Functional neck dissection. Anatomical grounds, surgical technique, clinical observations. Ann Otol Rhinol Laryngol. (1983) 92:215–22. doi: 10.1177/000348948309200301
3. Ferlito A, Rinaldo A. Osvaldo suarez: often-forgotten father of functional neck dissection (in the non-Spanish-speaking literature). Laryngoscope. (2004) 114:1177–8. doi: 10.1097/00005537-200407000-00008
4. Inoue H, Nibu K, Saito M, Otsuki N, Ishida H, Onitsuka T, et al. Quality of life after neck dissection. Arch Otolaryngol Head Neck Surg. (2006) 132:662–6. doi: 10.1001/archotol.132.6.662
5. Rivard AB, Kortz MW, Burns B. Anatomy, Head and Neck, Internal Jugular Vein. Treasure Island, FL: StatPearls (2020).
6. Downie SA, Schalop L, Mazurek JN, Savitch G, Lelonek GJ, Olson TR. Bilateral duplicated internal jugular veins: case study and literature review. Clin Anat. (2007) 20:260–6. doi: 10.1002/ca.20366
7. Hashimoto Y, Otsuki N, Morimoto K, Saito M, Nibu K. Four cases of spinal accessory nerve passing through the fenestrated internal jugular vein. Surg Radiol Anat. (2012) 34:373–5. doi: 10.1007/s00276-011-0875-x
8. Bathala S, Makura ZG. Duplication of the right internal jugular vein: a case report. Ear Nose Throat J. (2015) 94:236–7. doi: 10.1177/014556131509400609
9. Biondi P, Colella G, Gherardini G, Tartaro G, Rauso R. Internal jugular vein duplication. Indian J Plast Surg. (2009) 42:273–4. doi: 10.1055/s-0039-1699365
10. Cvetko E. Unilateral fenestration of the internal jugular vein: a case report. Surg Radiol Anat. (2015) 37:875–7. doi: 10.1007/s00276-015-1431-x
11. Ibrahim B, Berania I, Moubayed SP, Christopoulos A, Ayad T. Internal jugular vein duplication: anatomic relationship with the spinal accessory nerve. J Oral Maxillofac Surg. (2016) 74:1502.e1–4. doi: 10.1016/j.joms.2016.03.002
12. Moreno-Sanchez M, Hernandez Vila C, Gonzalez-Garcia R, Monje F. Fenestrated internal jugular vein: a rare finding in neck dissection. Int J Oral Maxillofac Surg. (2015) 44:1086–7. doi: 10.1016/j.ijom.2015.05.014
13. Prades JM, Timoshenko A, Dumollard JM, Durand M, Merzougui N, Martin C. High duplication of the internal jugular vein: clinical incidence in the adult and surgical consequences, a report of three clinical cases. Surg Radiol Anat. (2002) 24:129–32. doi: 10.1007/s00276-002-0020-y
14. Gardiner KJ, Irvine BW, Murray A. Anomalous relationship of the spinal accessory nerve to the internal jugular vein. Clin Anat. (2002) 15:62–3. doi: 10.1002/ca.1094
15. Turan-Ozdemir S, Coskun H, Balban M. Phlebectasia of the external jugular vein associated with duplication of the internal jugular vein. Clin Anat. (2004) 17:522–5. doi: 10.1002/ca.10253
16. Alaani A, Webster K, Pracy JP. Duplication of internal jugular vein and relation to the spinal accessory nerve. Br J Oral Maxillofac Surg. (2005) 43:528–31. doi: 10.1016/j.bjoms.2005.03.013
17. Nayak BS. Surgically important variations of the jugular veins. Clin Anat. (2006) 19:544–6. doi: 10.1002/ca.20268
18. Ozturk NC, Talas DU. Fenestration of internal jugular vein and relation to spinal accessory nerve: case report and review of the literature. Clin Anat. (2010) 23:883–4. doi: 10.1002/ca.20897
19. Dogan NU, Cicekcibasi AE, Fazliogullari Z, Yilmaz MT, Uysal II, Salbacak A, et al. Unilateral variations of vessels and nerves in the neck. Int J Morphol. (2010) 28:963–6. doi: 10.4067/S0717-95022010000300049
20. Wong BY, Strachan DR, Loney EL. Duplication of internal jugular veins: case report. J Laryngol Otol. (2010) 124:341–4. doi: 10.1017/S0022215109990855
21. Thakur JS, Sharma DR, Mohindroo NK. Double fenestration of the internal jugular vein: a rare anatomic variant. Ear Nose Throat J. (2012) 91:420–7. doi: 10.1177/014556131209101004
22. Kapre M, Mangalgiri AS. Clinical importance of duplication of internal jugular vein. Indian J Otolaryngol Head Neck Surg. (2012) 64:386–8. doi: 10.1007/s12070-011-0410-8
23. Bachoo I, Evans B. Duplication of the lower third of the internal jugular vein - case report and surgical implications. Br J Oral Maxillofac Surg. (2014) 52:772–3. doi: 10.1016/j.bjoms.2014.05.016
24. Pegot A, Guichard B, Peron JM, Trost O. Empty fenestration of the internal jugular vein: a rare phenomenon. Br J Oral Maxillofac Surg. (2015) 53:78–80. doi: 10.1016/j.bjoms.2014.09.005
25. Deepak CA, Sarvadnya JJ, Sabitha KS. Variant anatomy of internal jugular vein branching. Ann Maxillofac Surg. (2015) 5:284–6. doi: 10.4103/2231-0746.175751
26. Contrera KJ, Aygun N, Ward BK, Gooi Z, Richmon JD. Internal jugular vein duplication and fenestration: case series and literature review. Laryngoscope. (2016) 126:1585–8. doi: 10.1002/lary.25743
27. Nayak SB. Split internal jugular vein: surgical and radiological implications. Br J Oral Maxillofac Surg. (2017) 55:870–1. doi: 10.1016/j.bjoms.2017.08.002
28. Cvetko E, Meznaric M. Concomitant fenestration and phlebectasia of the right internal jugular vein: a unique finding in anatomical dissection. Folia Morphol. (2017) 76:519–22. doi: 10.5603/FM.a2017.0009
29. Abakay MA, Simsek BM, Olgun B, Turkay R, Gunes S. Ultrasonic identification of internal jugular vein fenestration. Surg Radiol Anat. (2019) 41:1079–81. doi: 10.1007/s00276-019-02226-7
30. Anehosur V, Rajendiran S, Jayade GR, Kumar N. An unusual observation during neck dissection. J Maxillofac Oral Surg. (2016) 15:306–8. doi: 10.1007/s12663-015-0839-5
31. Kumar JI, Ma S, Agarwalla P, Shimony N, Liu SS. Anatomic alert: spinal accessory nerve traversing a fenestrated internal jugular vein. Br J Neurosurg. (2019) 33:673–4. doi: 10.1080/02688697.2019.1661969
32. Mumtaz S, Singh M. Surgical review of the anatomical variations of the internal jugular vein: an update for head and neck surgeons. Ann R Coll Surg Engl. (2019) 101:2–6. doi: 10.1308/rcsann.2018.0185
33. Towbin AJ, Kanal E. A review of two cases of fenestrated internal jugular veins as seen by CT angiography. AJNR Am J Neuroradiol. (2004) 25:1433–4.
34. Torres US, Teixeira AC, Sanches RA. Fenestrated internal jugular vein: diagnosis by multidetector CT. J Vasc Interv Radiol. (2014) 25:152–3. doi: 10.1016/j.jvir.2013.10.015
35. Kayashima K, Fukui R, Imai K, Murashima K. Images in anesthesiology: ultrasonographic images of internal jugular vein duplication. Anesthesiology. (2016) 124:958. doi: 10.1097/ALN.0000000000000869
36. Rossi A, Tortori-Donati P. Internal jugular vein phlebectasia and duplication: case report with magnetic resonance angiography features. Pediatr Radiol. (2001) 31:134. doi: 10.1007/s002470000350
Keywords: internal jugular vein, fenestration, duplication, malformation, spinal accessory nerve, neck dissection
Citation: Wang X, Peng L, Guo H, Hernesniemi J, Xiong X, Andrade-Barazarte H and Qian R (2020) Internal Jugular Vein Fenestration and Duplication: Anatomical Findings, Prevalence, and Literature Review. Front. Surg. 7:593367. doi: 10.3389/fsurg.2020.593367
Received: 10 August 2020; Accepted: 06 October 2020;
Published: 13 November 2020.
Edited by:
Claudio Roberto Cernea, University of São Paulo, BrazilReviewed by:
Georgios Psychogios, University Hospital of Ioannina, GreeceA. B. Zulkiflee, University Malaya Medical Centre, Malaysia
Copyright © 2020 Wang, Peng, Guo, Hernesniemi, Xiong, Andrade-Barazarte and Qian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Hugo Andrade-Barazarte, hugoandrade2@yahoo.es; Rongjun Qian, qrjqqx@163.com