AUTHOR=Iafrate Massimo , Motterle Giovanni , Zaborra Carlotta , Leone Niccolò , Prayer-Galetti Tommaso , Zattoni Filiberto , Guttilla Andrea , Cappellesso Rocco , Dei Tos Angelo Paolo , Rossi Carlo Riccardo , Del Fiore Paolo , Rastrelli Marco , Mocellin Simone 

TITLE=Spermatic Cord Sarcoma: A 20-Year Single-Institution Experience

JOURNAL=Frontiers in Surgery

VOLUME=7

YEAR=2020

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2020.566408

DOI=10.3389/fsurg.2020.566408

ISSN=2296-875X

ABSTRACT=<p><bold>Introduction:</bold> Spermatic cord sarcomas represent a rare genitourinary malignancy with a challenging diagnostic and therapeutic pathway. Different histotypes have been described and prognostic factors remain poorly defined due to the paucity of data presented in literature.</p><p><bold>Methods:</bold> Retrospective chart review of 22 adult patients treated for spermatic cord sarcoma in a single institution in the last 20 years was performed. Clinicopathological characteristics of the tumors were collected with primary and subsequent treatment. Survival analysis was performed in order to identify prognostic factors of disease-specific survival.</p><p><bold>Results:</bold> The median age at diagnosis was 68 years (58–78), the most common histotype was liposarcoma (14/22), and most patients (63.6%) were found to have positive surgical margins after surgery. The 5-year cancer specific survival was 91.3%. Grading (<italic>p</italic> = 0.480), histotype (<italic>p</italic> = 0.327), and type of intervention (<italic>p</italic> = 0.732) were not associated with survival. All patients dead of disease had positive surgical margins (<italic>p</italic> = 0.172).</p><p><bold>Conclusion:</bold> We report a good prognosis at 5 years. Wide radical resection remains the first and probably the most important step; thus, according also to literature, negative surgical margins should be aimed.</p>