AUTHOR=Fennell Vernard S. , Kalani M. Yashar S. , Atwal Gursant , Martirosyan Nikolay L. , Spetzler Robert F. 

TITLE=Biology of Saccular Cerebral Aneurysms: A Review of Current Understanding and Future Directions

JOURNAL=Frontiers in Surgery

VOLUME=3

YEAR=2016

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2016.00043

DOI=10.3389/fsurg.2016.00043

ISSN=2296-875X

ABSTRACT=<p>Understanding the biology of intracranial aneurysms is a clinical quandary. How these aneurysms form, progress, and rupture is poorly understood. Evidence indicates that well-established risk factors play a critical role, along with immunologic factors, in their development and clinical outcomes. Much of the expanding knowledge of the inception, progression, and rupture of intracranial aneurysms implicates inflammation as a critical mediator of aneurysm pathogenesis. Thus, therapeutic targets exploiting this arm of aneurysm pathogenesis have been implemented, often with promising outcomes.</p>