AUTHOR=Bi Wenya Linda , Zhang Michael , Wu Winona W. , Mei Yu , Dunn Ian F. TITLE=Meningioma Genomics: Diagnostic, Prognostic, and Therapeutic Applications JOURNAL=Frontiers in Surgery VOLUME=3 YEAR=2016 URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2016.00040 DOI=10.3389/fsurg.2016.00040 ISSN=2296-875X ABSTRACT=

There has been a recent revolution in our understanding of the genetic factors that drive meningioma, punctuating an equilibrium that has existed since Cushing’s germinal studies nearly a century ago. A growing appreciation that meningiomas share similar biologic features with other malignancies has allowed extrapolation of management strategies and lessons from intra-axial central nervous system neoplasms and systemic cancers to meningiomas. These features include a natural proclivity for invasion, frequent intratumoral heterogeneity, and correlation between biologic profile and clinical behavior. Next-generation sequencing has characterized recurrent somatic mutations in NF2, TRAF7, KLF4, AKT1, SMO, and PIK3CA, which are collectively present in ~80% of sporadic meningiomas. Genomic features of meningioma further associate with tumor location, histologic subtype, and possibly clinical behavior. Such genomic decryption, along with advances in targeted pharmacotherapy, provides a maturing integrated view of meningiomas. We review recent advances in meningioma genomics and probe their potential applications in diagnostic, therapeutic, and prognostic frontiers.