AUTHOR=Matthyssens Lucas E. , Creytens David , Ceelen Wim P. 

TITLE=Retroperitoneal Liposarcoma: Current Insights in Diagnosis and Treatment

JOURNAL=Frontiers in Surgery

VOLUME=2

YEAR=2015

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2015.00004

DOI=10.3389/fsurg.2015.00004

ISSN=2296-875X

ABSTRACT=<p>Retroperitoneal liposarcoma (RLS) is a rare, biologically heterogeneous tumor that present considerable challenges due to its size and deep location. As a consequence, the majority of patients with high-grade RLS will develop locally recurrent disease following surgery, and this constitutes the cause of death in most patients. Here, we review current insights and controversies regarding histology, molecular biology, extent of surgery, (neo)adjuvant treatment, and systemic treatment including novel targeted agents in RLS.</p>