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ORIGINAL RESEARCH article

Front. Stroke
Sec. Population Health and Risk Factors of Stroke
Volume 3 - 2024 | doi: 10.3389/fstro.2024.1164878

Polymorphism of MTHFR C677T gene and its influence on the therapeutic effect of homocysteine in patients with H type hypertension

Provisionally accepted
Ziwen Wang Ziwen Wang Yujie Xu Yujie Xu Han Ren Han Ren *Jinghui Wang Jinghui Wang *Juan Gao Juan Gao *
  • Baoding First Central Hospital, Baoding, China

The final, formatted version of the article will be published soon.

    Objective: To investigate the distribution characteristics of methylenetetrahydrofolate reductase(MTHFR) C677T gene in h-type hypertension patients and the effect of different genotypes on the therapeutic effect of folic acid intervention on homocysteine(Hcy) reduction. Methods: 398 patients with type H hypertension were selected and the MTHFR C677T gene was detected in all subjects. 90-day folic acid (0.8mg/d) intervention treatment was given on the basis of routine treatment. According to the results of two plasma Hcy reviews, patients were divided into the ideal intervention group(Hcy decreased to 80% or normal at 30 days; On day 90, Hcy decreased to 50% or normal), and the relatively ideal intervention group(on day 30, Hcy did not decrease to 80% and did not fall to normal levels; At 90 days, Hcy decreased to 50% or normal), and the unsatisfactory intervention group(at 90 days, Hcy did not decrease to 50% and did not fall to normal levels). Multifactor logistic regression was used to analyze the relationship between MTHFR C677Tgenotype and the effect of folic acid on plasma Hcy reduction(P<0.05 means the difference is statistically significant). Results: Logistic regression analysis was conducted to analyze the outcome of therapeutic effect by combining gender, baseline Hcy, folic acid, uric acid and creatinine, and the results showed that the T allele was significantly associated with poor prognosis. In codominant models, TT genotype was associated with poor prognosis. This was also true in the recessive model. In the dominant model, however, mutations were not associated with poor prognosis(relatively ideal group vs. ideal group OR=0.752, 95%CI: 0.533, 8.450, P>0.05; unsatisfactory group vs. ideal group OR=0.960, 95%CI: 0.511, 13.362, P>0.05). Conclusion: Patients with H-type hypertension with the T allele and TT genotype were less sensitive to the reduction of Hcy by 0.8 mg/d folic acid, requiring adjustment of folic acid dosing or combination of other medications, in order to make up for the gene mutation caused by the decline in the activity of metabolic enzymes.

    Keywords: MTHFR C677T gene, H type hypertension, Homocysteine, treatment 752, influence

    Received: 15 Feb 2023; Accepted: 04 Jan 2024.

    Copyright: © 2024 Wang, Xu, Ren, Wang and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Han Ren, Baoding First Central Hospital, Baoding, China
    Jinghui Wang, Baoding First Central Hospital, Baoding, China
    Juan Gao, Baoding First Central Hospital, Baoding, China

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