AUTHOR=Nwafor Divine C. , Brichacek Allison L. , Rallo Michael S. , Bidwai Nina , Marsh Robert A. 

TITLE=Subarachnoid hemorrhage: New insights on pathogenesis

JOURNAL=Frontiers in Stroke

VOLUME=2

YEAR=2023

URL=https://www.frontiersin.org/journals/stroke/articles/10.3389/fstro.2023.1110506

DOI=10.3389/fstro.2023.1110506

ISSN=2813-3056

ABSTRACT=<p>Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke characterized by high morbidity and mortality. Saccular intracranial aneurysms account for most cases of SAH. While the role of hemodynamic stress and inflammation have been extensively studied in SAH, little is known about the role of the microbiome in SAH despite recent studies uncovering new insights on the effects of microbiome alteration in ischemic stroke. This review presents the current knowledge around the role of the microbiome in intracranial aneurysm formation and rupture. We also highlight the influence of diet on intracranial aneurysm formation and provide evidence that corroborates the targeting of inflammatory pathways as a potential strategy to curb SAH-associated neurological dysfunction.</p>