AUTHOR=Ren Xuefang Sophie , Choi Huimahn A. , Gusdon Aaron M. , Hu Heng , Savarraj Jude , Paz Atzhiry , Kitagawa Ryan S. , Simpkins James W. TITLE=Blood substitution—More challenges for translational significance JOURNAL=Frontiers in Stroke VOLUME=1 YEAR=2022 URL=https://www.frontiersin.org/journals/stroke/articles/10.3389/fstro.2022.1050434 DOI=10.3389/fstro.2022.1050434 ISSN=2813-3056