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CLINICAL TRIAL article
Front. Sports Act. Living
Sec. Physical Activity in the Prevention and Management of Disease
Volume 7 - 2025 | doi: 10.3389/fspor.2025.1534861
Effects of a Strength Physical Exercise Program in Chronic Lymphocytic Leukemia Patients on Quality of Life, Mental Health, and Frailty: A Randomized Controlled Trial Study Protocol
Provisionally accepted
Juan Luis Sánchez González 1
Eduardo Fernandez 1
ROBERTO MÉNDEZ-SÁNCHEZ 1
Luis Polo-Ferrero 1
Ana Silvia Puente-González 1 Cristina de Ramon 2 Sara Marcos-Asensio 2 Patricia Blázquez-Benito 2
Almudena Navarro-Bailón 2*
Fermin Sanchez-Guijo 2
Carlos Martín-Sánchez 1- 1 University of Salamanca, Salamanca, Spain
- 2 University of Salamanca Health Care Complex, Salamanca, Spain
Background: Chronic lymphocytic leukemia (CLL) is a type of cancer that affects the blood and bone marrow, and it is the most prevalent form of leukemia in adults. Many patients experience symptoms that can significantly impact their quality of life, particularly in terms of physical ability, emotional health, and fatigue. Therapeutic exercise has shown to be an effective intervention for alleviating both physical and psychological symptoms in these patients. Specifically, strength training may help address some common treatment side effects. Objective: This study aims to evaluate the effects of a therapeutic exercise program, focused on frailty in patients with CLL, along with secondary objectives including impacts on functional capacity, quality of life, psychological status, sleep quality, body composition, anthropometric variables, lipid profile and on proteins related to the immune system and inflammation. Methods: An open label, randomized controlled trial will be carried out with 36 participants, divided into an intervention group (supervised resistance training twice a week and home exercises) and a control group (home exercise only). The primary outcome measure is fraility, assessed using Short Physical Performance Battery (SPPB). Secondary outcomes include assessments using HADS, FACT-F, EORTC QLQ-C30, EORT QLQ-CLL17. Results and Conclusions: This study will explore how physical exercise can improve quality of life and various health metrics in patients with CLL. By creating customized exercise protocols, the research seeks to boost patient well-being, improve treatment outcomes, and lessen debilitating side effects, ultimately promoting the integration of physical activity into routine care. This clinical trial has been registered on ClinicalTrials.gov (NCT06654206).
Keywords: Exercise, chronic lymphocytic leukemia, Cancer, Physiotherapy, protocol
Received: 16 Dec 2024; Accepted: 24 Feb 2025.
Copyright: © 2025 Sánchez González, Fernandez, MÉNDEZ-SÁNCHEZ, Polo-Ferrero, Puente-González, de Ramon, Marcos-Asensio, Blázquez-Benito, Navarro-Bailón, Sanchez-Guijo and Martín-Sánchez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Almudena Navarro-Bailón, University of Salamanca Health Care Complex, Salamanca, Spain
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