Hannah J. Moir
Marcin Maciejczyk
Mateusz Maciejczyk
Felipe J. Aidar
Hamid Arazi- 1School of Life Sciences, Pharmacy and Chemistry, Faculty of Health, Science, Social Care and Education, Kingston University, London, United Kingdom
- 2EMJ, London, United Kingdom
- 3Faculty of Physical Education and Sport, University School of Physical Education, Kraków, Poland
- 4Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, Białystok, Poland
- 5Department of Physical Education, Federal University of Sergipe, São Cristóvão, Brazil
- 6Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran
Editorial on the Research Topic
Exercise-induced oxidative stress and the role of antioxidants in sport and exercise
Introduction
Oxidative stress in the human body results from an imbalance between the antioxidant system and the generation of reactive oxygen (ROS) and nitrogen species (RNS) (1). The consequence of high disturbances of redox homeostasis is impaired intra- and intercellular signalling pathways controlled by redox processes, as well as damage to molecules induced by the overproduction of ROS and RNS (2). These oxidative stress markers are generated in muscle fibres during rest, and their production is increased during muscle contraction. Exercise-induced oxidative stress could be detrimental to health and is associated with oxidant damage to macromolecular structures and accelerated muscular fatigue (2, 3).
Antioxidative enzymes serve as an important antioxidant defence line against such oxidative stress (4). Conversely, the exercise-induced overproduction of ROS in skeletal muscle can also play a vital role in skeletal muscle adaptations to different types of high-intensity exercise training, particularly endurance training (5). The extent of disruption in redox homeostasis depends on, among other factors, the duration and intensity of the effort, the level of antioxidants, and the nutritional, and physiological status of the individual, and there may be sex differences between males and females in this regard (6–8).
The aim of this Research Topic is to provide an article collection that enhances scientific knowledge and provides insights into exercise-induced oxidative stress and the role of antioxidant supplementation in sport and exercise. The current issue comprises a selection of papers covering topics such as diet and nutritional supplements for managing exercise-induced damage and oxidative stress, as well as exercise training and interventions to combat fatigue.
The contributions originate from several fields within Exercise Physiology and Sport and Exercise Nutrition, encompassing diverse perspectives. All the articles in this Research Topic are centered around one or more of the aforementioned research areas, as evidenced below.
Nutritional strategies for mitigating exercise-induced damage and oxidative stress
The contributions in this section highlight the potential benefits of appropriate dietary interventions to support athletic performance and overall health (9, 10).
Zare et al. investigated the link between male football players’ diet and their oxidative biomarkers, finding that football players had lower excretion of 8-hydroxy-2-deoxyguanosine (8-OHdG) and F2alpha-isoprostane (F2a-IP) and dietary inflammatory index, as well as higher dietary total antioxidant capacity and dietary phytochemical index (P < 0.001) compared to non-athlete controls. These dietary indices were associated with oxidative biomarkers, indicating the importance of a healthy diet in reducing oxidative stress, and suggesting that an anti-inflammatory, antioxidant-rich diet may help reduce oxidative stress in athletes. Further research is needed to elucidate the underlying mechanisms.
Zhang et al. explored the potential role of Pterostilbene (PTE), a phenolic compound derived from blueberries and grapes, in protecting the intestinal epithelial barrier during high-intensity exercise. Their findings in mouse running model showed that 100 mg/kg/day of PTE significantly attenuated the loss of the intestinal epithelial barrier induced by exercise for up to 12 h. In vitro, PTE promoted the expression of intestinal epithelial tight junction (TJ) molecules. Additionally, the authors identified that the exercise led to an abundance of gut bacterium Alistipesis, which is associated with lipopolysaccharide (LPS) production which was not reversed by the PTE. This study highlights the potential of PTE as a possible nutritional supplement for preserving the integrity of the intestinal epithelial barrier, which may have protective effects on gastrointestinal health in individuals engaging in high-intensity exercise. Further research is warranted to extrapolate these findings to a human athletic population.
Combatting fatigue: exercise training and interventions
High-intensity exercise can induce fatigue, potentially due to an excess of ROS, leading to reduced functions and increased injury risk (11).
Silva-Reis et al. investigated the effects of a 12-week combined aerobic and resistance training programme on lung function and mechanics and markers of airway fibrosis in obese females. The study demonstrated beneficial effects on lung function and mechanics, with improved forced vital capacity, and peak expiratory flow, with improvements in airway resistance in all groups (non-obese, obese, and obese Grade I females). The authors also observed reduced pro-fibrotic insulin-like growth factor 1 (IGF-1) and increased anti-fibrotic Klotho levels in those overweight or obese. These findings indicate the potential benefits of combined physical exercise in improving respiratory health in those overweight and obese by reducing fibrotic processes in the lungs.
Molecular hydrogen (H2), known for its antioxidant and anti-inflammatory properties (12), has been suggested as a potential strategy to alleviate fatigue and improve aerobic capacity (13), but its effects have not been fully characterised.
A study by Hong et al. demonstrated the effects of inhaling H2 gas before high-intensity cycling on physical fatigue and prefrontal cortex activation. They found that inhaling H2 gas (21.57% oxygen and 4.08% H2) for 20 min at 1,800 ml/min prior to exercise, reduced ratings of perceived exertion and heart rate during cycling, indicating reduced physical fatigue. Additionally, prefrontal cortex activation was maintained at high-intensity exercise (75% and 100% maximum workload). The study highlights how H2 gas inhalation could potentially enhance exercise performance and reduce fatigue in athletes. However, further studies are required to understand the different exercise protocols and establish an understanding of the mechanisms involved.
Finally, Hong et al. conducted a systematic review and meta-analysis on the effects of H2 intake on fatigue and aerobic capacity in healthy adults. The meta-analysis included 19 studies utilising H2 supplementation. Pooled effect sizes demonstrated a small significant effect on perceived exertion and blood lactate, but no impact on aerobic capacity (VO2max, VO2peak) was identified. The findings provide moderate evidence that H2 supplementation may alleviate fatigue in healthy adults but does not enhance aerobic capacity. The effects of H2 on fatigue may be influenced by factors such as training status, intervention period, and exercise types. These findings suggest that H2 supplementation may be beneficial for reducing perceived exertion and fatigue during exercise in healthy individuals. However, further investigation is required to determine the dose-response and impact on injury risk over time.
Perspectives
In conclusion, this Research Topic offers insights into the role of diet and nutritional supplements in managing exercise-induced damage and oxidative stress, supporting overall health and athletic performance. Pterostilbene may have protective effects for the intestinal epithelial barrier during high-intensity exercise. Combined aerobic and resistance training can improve lung function, mechanics, and immune response, benefiting overweight and obese individuals. Hydrogen gas supplementation may alleviate fatigue in healthy adults, but it does not appear to enhance aerobic capacity. Further investigation is needed to understand the impact and mechanisms of these interventions on exercise performance and injury risk. The contributions in this Research Topic contribute to the growing body of knowledge on exercise-induced oxidative stress and its management, offering valuable insights for athletes, coaches, and researchers in the fields of Exercise Physiology and Sport and Exercise Nutrition.
Author contributions
HM: Conceptualization, Data curation, Formal Analysis, Writing – original draft, Writing – review & editing; MM: Conceptualization, Writing – original draft, Writing – review & editing; MM: Conceptualization, Writing – original draft, Writing – review & editing; HA: Conceptualization, Formal Analysis, Writing – original draft, Writing – review & editing; FA: Conceptualization, Writing – original draft, Writing – review & editing.
Acknowledgments
We deeply thank all the authors and reviewers who have participated in this Research Topic.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
1. Schieber M, Chandel NS. ROS Function in redox signaling and oxidative stress. Curr Biol. (2014) 24(10):R453–62. doi: 10.1016/j.cub.2014.03.034
2. Wang F, Wang X, Liu Y, Zhang Z. Effects of exercise-induced ROS on the pathophysiological functions of skeletal muscle. Oxid Med Cell Longev. (2021):3846122. doi: 10.1155/2021/3846122
3. Sharifi-Rad M, Anil Kumar NV, Zucca P, Varoni EM, Dini L, Panzarini E, et al. Lifestyle, oxidative stress, and antioxidants: back and forth in the pathophysiology of chronic diseases. Front Physiol. (2020) 11:694. doi: 10.3389/fphys.2020.00694
4. Weydert CJ, Cullen JJ. Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue. Nat Protoc. (2010) 5:51–66. doi: 10.1038/nprot.2009.197
5. He F, Li J, Liu Z, Chuang CC, Yang W, Zuo L. Redox mechanism of reactive oxygen species in exercise. Front Physiol. (2016) 7:486. doi: 10.3389/fphys.2016.00486
6. Tiberi J, Cesarini V, Stefanelli R, Canterini S, Fiorenza MT, La Rosa P. Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology. Mech Ageing Dev. (2023) 211:111802. doi: 10.1016/j.mad.2023.111802
7. Matta L, de Faria CC, De Oliveira DF, Andrade IS, Lima-Junior NC, Gregório BM, et al. Exercise improves redox homeostasis and mitochondrial function in white adipose tissue. Antioxidants (Basel). (2022) 11(9):1689. doi: 10.3390/antiox11091689
8. Tauler Riera P. Redox status. In: Mooren FC, editor. Encyclopedia of exercise medicine in health and disease. Berlin, Heidelberg: Springer (2016):751–3. doi: 10.1007/978-3-540-29807-6_167
9. Vitale K, Getzin A. Nutrition and supplement update for the endurance athlete: review and recommendations. Nutrients. (2019) 11(6):1289. doi: 10.3390/nu11061289
10. Strasser B, Wolters M, Weyh C, Krüger K, Ticinesi A. The effects of lifestyle and diet on gut Microbiota composition, inflammation and muscle performance in our aging society. Nutrients. (2021) 13(6):2045. doi: 10.3390/nu13062045
11. Debold EP. Potential molecular mechanisms underlying muscle fatigue mediated by reactive oxygen and nitrogen species. Front Physiol. (2015) 6:239. doi: 10.3389/fphys.2015.00239
12. Ge L, Yang M, Yang NN, Yin XX, Song WG. Molecular hydrogen: a preventive and therapeutic medical gas for various diseases. Oncotarget. (2017) 8(60):102653–73. doi: 10.18632/oncotarget.21130
Keywords: oxidative stress, exercise-induced oxidative damage, fatigue, high-intensity (strenous) exercise, redox, antioxidants
Citation: Moir HJ, Maciejczyk M, Maciejczyk M, Aidar FJ and Arazi H (2023) Editorial: Exercise-induced oxidative stress and the role of antioxidants in sport and exercise. Front. Sports Act. Living 5:1269826. doi: 10.3389/fspor.2023.1269826
Received: 30 July 2023; Accepted: 3 August 2023;
Published: 15 August 2023.
Edited and Reviewed by: Giuseppe D’Antona, University of Pavia, Italy
© 2023 Moir, Maciejczyk, Maciejczyk, Aidar and Arazi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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