This article is a correction to:
Estrogen to Progesterone Ratio and Fluid Regulatory Responses to Varying Degrees and Methods of Dehydration
Gabrielle E. W. Giersch1,2*
Nisha Charkoudian1
Margaret C. Morrissey3
Cody R. Butler3
Abigail T. Colburn4
Aaron R. Caldwell1,2
Stavros A. Kavouras4
Douglas J. Casa3- 1Thermal and Mountain Medicine Division, United States Army Research Institute for Environmental Medicine, Natick, MA, United States
- 2Oak Ridge Institute for Science and Education, Belcamp, MD, United States
- 3Korey Stringer Institute, Department of Kinesiology, University of Connecticut, Storrs, CT, United States
- 4Hydration Science Laboratory, Arizona State University, Tempe, AZ, United States
A Corrigendum on
Estrogen to Progesterone Ratio and Fluid Regulatory Responses to Varying Degrees and Methods of Dehydration
by Giersch, G. E. W., Charkoudian, N., Morrissey, M. C., Butler, C. R., Colburn, A. T., Caldwell, A. R., Kavouras, S. A., and Casa, D. J. (2021). Front. Sports Act. Living 3:722305. doi: 10.3389/fspor.2021.722305
In the original article, there were missing citations in the Introduction section, paragraph 3, page 2. References Calzone et al. (2001) and Stachenfeld and Taylor (2005) have now been included. The corrected paragraph appears below:
For women, sex hormones interact with the mechanisms governing body fluid balance and circulating levels of fluid regulatory hormones are altered by changes in estrogen and progesterone concentration (Stachenfeld et al., 2000; Calzone et al., 2001; Stachenfeld and Taylor, 2005; Stachenfeld, 2008; Giersch et al., 2019). Estrogen is positively related to AVP and high estrogen concentration decreases the osmotic threshold for AVP synthesis (Stachenfeld et al., 1999; Stachenfeld and Keefe, 2002), suggesting increased AVP secretion at lower levels of dehydration. Estrogen has also been positively correlated with copeptin across the menstrual cycle (Blum et al., 2014). Progesterone has also been observed to impact fluid retention via aldosterone and AVP pathways, and may also increase plasma volume independent of estrogen (Calzone et al., 2001; Stachenfeld and Taylor, 2005), but the precise mechanism of action of progesterone in this regard remains unclear. While estrogen and progesterone both have independent functions throughout the body, they appear to have opposing effects with respect to vascular function (Stephenson and Kolka, 1999; Wenner et al., 2011) and body temperature regulation (Stachenfeld et al., 2001a; Charkoudian and Stachenfeld, 2014). This relationship may also be present with respect to body fluid balance given the varying mechanisms through which estrogen and progesterone alter fluid regulation (Calzone et al., 2001; Stachenfeld et al., 2001b; Stachenfeld and Keefe, 2002; Stachenfeld and Taylor, 2005). Thus, fluid volume regulation may be altered based the concentrations of the hormones relative to each other at a given point in the menstrual cycle (Owen, 1975). This highlights the importance of assessing the relationship between estrogen and progesterone, or the estrogen-to-progesterone ratio (E:P). E:P incorporates the relative concentrations of the two hormones in circulation, allowing for consideration of which is dominant at any given time.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Calzone, W. L., Silva, C., Keefe, D. L., and Stachenfeld, N. S. (2001). Progesterone does not alter osmotic regulation of AVP. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281, R2011–R2020. doi: 10.1152/ajpregu.2001.281.6.R2011
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Keywords: female sex hormones, fluid balance, fluid restriction, copeptin, exercise heat stress
Citation: Giersch GEW, Charkoudian N, Morrissey MC, Butler CR, Colburn AT, Caldwell AR, Kavouras SA and Casa DJ (2022) Corrigendum: Estrogen to Progesterone Ratio and Fluid Regulatory Responses to Varying Degrees and Methods of Dehydration. Front. Sports Act. Living 4:848595. doi: 10.3389/fspor.2022.848595
Received: 04 January 2022; Accepted: 10 January 2022;
Published: 10 February 2022.
Edited and reviewed by: David Christopher Nieman, Appalachian State University, United States
Copyright © 2022 Giersch, Charkoudian, Morrissey, Butler, Colburn, Caldwell, Kavouras and Casa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Gabrielle E. W. Giersch, gegiersch@gmail.com