AUTHOR=Ratliff Kayla M. , Kerksick Chad M. , Moon Jessica M. , Hagele Anthony M. , Boring Johnathan L. , Walden Kylie , Gaige Connor J. , Stecker Richard A. , Sunderland Kyle L. , Mumford Petey W. 

TITLE=Metabolic impact of feeding prior to a 60-min bout of moderate-intensity exercise in females in a fasted state

JOURNAL=Frontiers in Sports and Active Living

VOLUME=4

YEAR=2023

URL=https://www.frontiersin.org/journals/sports-and-active-living/articles/10.3389/fspor.2022.1070477

DOI=10.3389/fspor.2022.1070477

ISSN=2624-9367

ABSTRACT=<sec><title>Background</title><p>The metabolic impact of pre-exercise feeding of protein or carbohydrate on fat oxidation and energy expenditure rates, especially, in females, is poorly understood.</p></sec><sec><title>Methods</title><p>Recreationally active females (<italic>n</italic> = 15, 32 ± 10 years, 164.8 ± 5.6 cm, 63.5 ± 9.3 kg, 23.4 ± 3.2 kg/m<sup>2</sup>) completed four testing sessions in a randomized, double-blind, crossover fashion after fasting overnight. Participants ingested isovolumetric and isoenergetic solutions containing either 25 g of whey protein, casein protein, carbohydrate (CHO), or a non-caloric placebo (PLA). Participants then completed 60 min of treadmill exercise at 15% below ventilatory threshold 30 min after ingestion. Respiratory exchange ratio (RER) was evaluated throughout exercise and resting energy expenditure (REE) was assessed pre-exercise, and 0-, 60-, and 120-min post-exercise.</p></sec><sec><title>Results</title><p>A significant condition x time interaction was observed for RER (<italic>p</italic> = 0.008) during exercise, with CHO exhibiting higher RER values (vs. PLA) at four time points. A significant main effect for condition was observed for carbohydrate (<italic>p</italic> = 0.001) and fat (<italic>p</italic> = 0.02) oxidation rates during exercise, with fat oxidation rates being higher in PLA vs. CHO (<italic>p</italic> = 0.01). When total fat oxidized was calculated across the entire exercise bout, a significant main effect for condition was observed (<italic>p</italic> = 0.01), with PLA being greater than CHO (<italic>p</italic> = 0.04). A significant condition x time interaction (<italic>p</italic> = 0.02) was found for both absolute and normalized REE, with casein and whey protein having significantly higher values than CHO (<italic>p</italic> &lt; 0.05) immediately post-exercise.</p></sec><sec><title>Conclusion</title><p>When compared to a fasted control (PLA), consuming CHO, but not protein, decreased total fat oxidation prior to a 60-min bout of moderate-intensity exercise in females.</p></sec>