- 1Department of Physical Education and Sport, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain
- 2School of Sport and Exercise Science, University of Worcester, Worcester, United Kingdom
- 3Research Group HUM-643, Department of Integrated Didactics, University of Huelva, Huelva, Spain
- 4Department of Energy Engineering, University of Seville, Seville, Spain
The main goal of this study was to analyse the pacing strategies displayed by the winners of the six World Marathon Majors in order to determine which race offers the greatest potential for future world record attempts. For data analysis, the total distance of the marathon was divided into eight sections of 5 km and a final section of 2.195 km, and time needed to complete each section was calculated in seconds. When we analyzed the mean winning time in the last 13 editions of each of the World Marathon Majors, we observed differences between New York and London (ES = 1.46, moderate effect, p = 0.0030), New York and Berlin (ES = 0.95, small effect, p = 0.0001), London and Boston (ES = 0.08, small effect, p = 0.0001), Boston and Berlin (ES = 0.10, small effect, p = 0.0001), Boston and Chicago (ES = 0.16, small effect, p = 0.0361), Berlin and Tokyo (ES = 0.20, small effect, p = 0.0034), Berlin and Chicago (ES = 0.27, small effect, p = 0.0162). This study shows that Berlin and London are likely candidates for future world record attempts, whilst such a performance is unlikely in New York or Boston.
Introduction
The pacing strategy adopted during competition is crucial in determining marathon running performance (Abbiss and Laursen, 2008; Ely et al., 2008; March et al., 2011; Renfree and Gibson, 2013). Pacing, which has been described as the ability to use and distribute energy resources efficiently during athletic competition (Foster et al., 1993), aims to optimize the use of physiological reserves before the end of the race. This would help in avoiding premature fatigue (Skorski and Abbiss, 2017) and a subsequent reduction in speed before task completion (Foster et al., 2004; Hettinga et al., 2007; Tucker and Noakes, 2009).
Different studies have identified a number of factors that influence pacing during a marathon race, including changes in terrain or altitude (Haney and Mercer, 2011), as well as environmental and body temperature (Marino et al., 2004; El Helou et al., 2012; Hoogkamer et al., 2017). To date, there is no consensus about the mechanisms through which the regulation of pace is achieved (Renfree et al., 2015), although factors such as the assessment of perceived exertion (Tucker and Noakes, 2009), the Hazard score (de Koning et al., 2011), and emotion (Baron et al., 2011; Venhorst et al., 2018) have all been studied.
Recently, it has been established that the pacing strategy adopted has a major influence on the performances achieved by world record breaking athletes (Díaz et al., 2018). In recent years, the world records have been achieved through progressively more consistent strategies than was the case in record performances of more than 25 years ago, which were typically characterized by a progressive reduction in speed (Díaz et al., 2018, 2019).
The present world record holder, Eliud Kipchoge of Kenya (2:01:39, Berlin Marathon, 16 September 2018) succeeded in lowering the previous record by 1 min and 18 s. This performance has increased speculation regarding the possibility of a sub 2 h performance (Hoogkamer et al., 2017; Sousa et al., 2018). Some authors and scientists have suggested that such a performance is physiologically impossible (Liu and Schutz, 1998; Weiss et al., 2016), whereas others argue that the barrier may be broken in the near future (Boullosa et al., 2011; Joyner et al., 2011; Hoogkamer et al., 2017; Sousa et al., 2018).
With regards to any attempt to break the 2 h barrier, previous research proposed the use of several pacemakers that should be replaced with other athletes as soon as the first ones become fatigued on a loop circuit, as was the case in the Nike Breaking2 attempt (Hoogkamer et al., 2017). However, this strategy is not allowed by the IAAF rules (2015), so the only option is to compete in legitimate races. This is where the Marathon Majors take special importance as since 1998 all world records have been broken in these competitions.
Therefore, the main goal of this study was to analyse the pacing strategies displayed by the winners of the six World Marathon Majors in order to determine which race offers the greatest potential for future world record attempts. We hypothesize that world records are more likely to be achieved in marathons with more even profiles and taking place in stable favorable such as Berlin.
Methods
Data were gathered from a publicly accessible website (Association of Road Running Statisticians' website, accessed 20 November 2018) providing the winners of the official World Marathon Majors for men between 2006 and 2018, which resulted in a sum of 76 winners. Each set of information included at least: the position, category, official final time, half-marathon time, and time data every 5 km.
The total distance of the marathon was divided into eight sections of 5 km and one section of 2.195 km, and time needed to complete each section was calculated in seconds. Full marathon average speed and the average speed of each section were calculated individually. The relative speed of each section for every runner was then calculated and presented as a percentage of the average speed for the full race.
The athletes were divided into six groups: (A) group of marathon Berlin (winners between 2006 and 2018), (B) group of marathon Boston (winners between 2006 and 2018), (C) group of marathon Chicago (winners between 2006 and 2018), (D) group of marathon London (winners between 2006 and 2018), (E) group of marathon New York (winners between 2006 and 2018, except the marathon of 2012 canceled by a hurricane), (F) group of marathon Tokyo (winners between 2007 and 2018, as before 2007 Tokyo was not part of the Worlds Marathon Majors).
The course information were retrieved through the official internet website for each city marathon, on marathon archive websites and from various media outlets.
Statistical Analysis
SPSS for Windows version 25.0 (SPSS, Inc., Chicago, IL) was used to analyze the data. Each data set was screened for normality of distribution and homogeneity of variances using a Shapiro-Wilk normality test and a Levene test, respectively. One-way analysis of variance (ANOVA) was used to compare the mean winning time in the last 13 editions of each of the World Marathon Majors. Two-way analysis of variance (ANOVA) with repeated measures for time was used to compare the pacing strategies between the winners of the six world marathons majors. When differences were found, a Tukey's range test was used for post-hoc comparisons. The magnitude of the differences or effect sizes (ES) were calculated according to Cohen's d (Cohen, 1998) and interpreted as small (>0.2 and <0.6), moderate (≥0.6 and <1.2), large (≥1.2 and <2.0) or very large (≥2.0 and <4) according to the scale proposed by Hopkins et al. (2009). Significance for all analyses was set at p < 0.05.
We acknowledge that such a statistical approach has been criticized as it may induce a greater risk of type I error (Sainani, 2018) and may lead to flawed inference (Sainani et al., 2019). However, it has a practical use in sport science studies (Batterham and Hopkins, 2019).
Results
Mean winning time in the last 13 editions of each of the World Marathon Majors are presented in Figure 1. We observed differences between New York and London (ES = 1.46, moderate effect, p = 0.0030), New York and Berlin (ES = 0.95, small effect, p = 0.0001), London and Boston (ES = 0.08, small effect, p = 0.0001), Boston and Berlin (ES = 0.10, small effect, p = 0.0001), Boston and Chicago (ES = 0.16, small effect, p = 0.0361), Berlin and Tokyo (ES = 0.20, small effect, p = 0.0034), Berlin and Chicago (ES = 0.27, small effect, p = 0.0162).
When individual 5 km segments were analyzed, differences were found in running speed relative to the whole race average (Figure 2). In the first 5 km section, New York was slower than Berlin (ES = 2.77, very large effect, p = 0.0001), London (ES = 3.36, very large effect, p = 0.0001), Tokyo (ES = 3.12, very large effect, p = 0.0001), Boston (ES = 2.06, very large effect, p = 0.0001), and Chicago (ES = 1.83, large effect, p = 0.0133). On the other hand, London was faster than Chicago (ES = 2.00, very large effect, p = 0.028).
Figure 2. Course profile and normalized average speed of World Marathon Majors' winners by 5 km sections. (A) Course profile and normalized average speed of Berlin Marathon. (B) Course profile and normalized average speed of Boston Marathon. (C) Course profile and normalized average speed of Chicago Marathon. (D) Course profile and normalized average speed of London Marathon. (E) Course profile and normalized average speed of New York Marathon. (F) Course profile and normalized average speed of Tokyo Marathon.
In section 6, New York again differed from other races, as it was faster than Berlin (ES = 1.55, large effect, p = 0.0133), London (ES = 1.89, large effect, p = 0.0003), Chicago (ES = 1.60, large effect, p = 0.0004), Boston (ES = 1.45, large effect, p = 0.0001), and Tokyo (ES = 1.79, large effect, p = 0.0008).
In section 8, we found the following differences: Berlin was slower than New York (ES = 0.55, small effect, p = 0.0029) and Boston (ES = 1.09, moderate effect, p = 0.0257), London was slower than New York (ES = 1.31, large effect, p = 0.0027), and Boston (ES = 1.11, moderate effect, p = 0.0240) and New York was faster than Tokyo (ES = 0.99, moderate effect, p = 0.0211).
In the final 2.2 km section, New York was faster than Berlin (ES = 0.73, moderate effect, p = 0.0043), London (ES = 0.85, moderate effect, p = 0.0126), Boston (ES = 0.98, moderate effect, p = 0.0002), and Tokyo (ES = 1.10, moderate effect, p = 0.0001).
Discussion
Analysis of winning times over a 13 year period indicates clear differences between the six World Marathon Majors (Figure 1). Although there are probably numerous reasons for this, course topography is likely important, especially in terms of its influence on the pacing behaviors displayed. For example, the New York race, which is characterized by substantial undulations, differs from the other races in the initial and final individual 5 km sections. Similarly, New York marathon is the only one of the Majors that consistently allows for a second half marathon faster than the first (ES = 4.90, very large effect). In contrast Berlin, which has the fastest average winning time and is the sight of the current world best performance is relatively flat, starts at an elevation of 38 m above sea level and never exceeds 53 m, and has a net downhill profile over the final 15 km.
The Boston marathon is notable in that we found larger variability in the overall winning times than was the case for the other races. This is in line with a larger analysis performed by Maffetone et al. (2017) who found that the Boston Marathon is characterized by large variability in performances due to external factors such as weather and specifically, the wind direction.
In relation to climate, other aspect that may influence the performance of athletes is temperature (El Helou et al., 2012). It is known that warm weather causes a major alteration of cardiovascular, metabolic, neuromuscular, and thermoregulatory function (Maughan et al., 2007). Consequently, it increases the risk of hyperthermia, directly affecting the central nervous system and contributing to the onset of fatigue during prolonged exercise (Marc et al., 2014). In this sense, El Helou et al. (2012) observed that, the higher the temperature increase, there is a drastic reduction in the running speed and significantly increases the percentage of athletes who retire. For example, in 2007 in the marathon in Chicago, 30.74% of the athletes withdrew, although the organizers tried to interrupt the competition with serious problems of dehydration and thermal shock syndromes (Roberts, 2010). Although we are unable to access data relating to climatic conditions at the time of every individual race, we speculate that variation between locations may at least partially account for the differences in performance we found. For example, with regards to the influence of temperature, Ely et al. (2007) indicated that the best historical times in the marathon have been achieved during the early morning, with cold ambient temperatures (10–15°C) and during the spring or autumn. In this regard, despite the high standard of competition during the summer in the Olympic Games, Continental or International Championships no world records and few good annual performances are established possibly by the temperatures during this period of year (i.e., London Olympics 2012: 27°C, Rio Olympics 2016: 21°C, Doha World Championship 2019: 32°C) (Marc et al., 2014).
One of the most important factors influencing marathon performance is the pacing adopted by athletes (Abbiss and Laursen, 2008; Díaz et al., 2018, 2019). Athletes aim to efficiently use and distribute their energetic resources during athletic competition (Foster et al., 1994), with the aim of using all available reserves before reaching the finish, thereby avoiding premature fatigue (Skorski and Abbiss, 2017) and a significant deceleration before the end (Foster et al., 2004; Hettinga et al., 2007; Tucker and Noakes, 2009). We can observe that in the Tokyo and Boston races, race winners typically slow with increasing distance, and therefore, display positive pacing profiles, unlike Berlin where the athletes display a more uniform speed throughout the whole race (Figure 2). Interestingly, the New York profile favors a fast end that never compensates for the slow pace of the first half, which reinforces the importance of a stable and constant intensity to perform optimally. There is evidence to suggest that, in a marathon, a pacing strategy characterized by very little speed changes across the race is optimal if the goal is to run as fast as possible (Angus, 2014). This observation is in line with that made by Díaz et al. (2018) who assessed the historical development of pacing strategies in world best marathon performances. This ability to achieve such a uniform pacing strategy may be enhanced through the use of designated “pacemakers” who may reduce the psychological burden of regulating speed in competition, and thereby improve performance (Zouhal et al., 2015). During a 3000 m running time trial, presence of a pacemaker resulted in lower blood lactate concentrations and reduced RPE (Zouhal et al., 2015). Running with pacemakers also helps eliminate air resistance, thereby saving energy and reducing oxygen consumption by 8% at a speed of 21.5 kph (Pugh, 1970). Furthermore, Rauch et al. (2013) suggested that pacemakers can act as a placebo, increasing the motivation of the athletes to maintain or increase the pace in the final kilometers.
Finally, it is important to emphasize that organizational and traditional factors specific to the individual races may help explain some of the findings of this analysis. For example, the Boston race, and since 2007, the New York race, do not use pacemakers to assist athletes in achieving faster times. In explaining the reasons for this, organizers of the New York race say the presence of pacemakers makes the competitions lose their essence because the athletes do not “start running” until the pacemakers drop out (Mehaffey, 2009). Furthermore, the performances of elite runners may be influenced by the prize money (Maffetone et al., 2017). The winners of the World Marathon Majors receive a prize of $250,000 in addition to an event specific prize that differs between races as well as bonuses for breaking world records. Times set at Boston are ineligible for record purposes due to the distance of the start line from the finish line which could result in favorable prevailing winds. Given that economic reasons are a primary motivational factor for East African runners (Onywera et al., 2006), it would therefore seem unlikely that an athlete considered to have a realistic chance of achieving a world best performance would attempt to do so at Boston, regardless of the course profile.
Conclusion
We have identified differences in overall performance and pacing behavior displayed by winners of the mens races over the last 13 editions of the World Marathon Majors series. Although these differences may be partially accounted for by course topography and environmental conditions, it seems likely that organizational issues and traditions may also have an influence. In terms of potential venues for future world record attempts, then historical data suggests that Berlin, which owns the 7 best performances of all time over this distance in men, is the most likely candidate whilst such a performance is unlikely in New York or Boston (which is ineligible anyway).
Data Availability Statement
All datasets generated for this study are included in the article/supplementary material.
Author Contributions
JD participated in the study design, collected all the data and participated in data analysis, statistical analysis, interpretation of the data, and manuscript editing. AR participated in the study design, participated in data analysis, statistical analysis, interpretation of the data, and manuscript editing. EF-O participated in the conception and design of the study and revised/reviewed the manuscript. MT designed and carried out these experiments, participated in data analysis, and statistical analysis. JS-C participated in the coordination of our study participated in data analysis, statistical analysis, interpretation of the data, and helped to polish the manuscript. All authors have read and approved the final version of the manuscript and agreed with the order of presentation of the authors.
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Acknowledgments
The authors wish to thank Miguel Villaseñor for his assistance in data collection.
References
Abbiss, C. R., and Laursen, P. B. (2008). Describing and understanding pacing strategies during athletic competition. Sports Med. 38, 239–252. doi: 10.2165/00007256-200838030-00004
Angus, S. D. (2014). Did recent world record marathon runners employ optimal pacing strategies? J. Sports S. 32, 31–45. doi: 10.1080/02640414.2013.803592
Baron, B., Moullan, F., Deruelle, F., and Noakes, T. D. (2011). The role of emotions on pacing strategies and performance in middle and long duration sport events. Br. J. Sports Med. 45, 511–517. doi: 10.1136/bjsm.2009.059964
Batterham, A. M., and Hopkins, W. G. (2019). The problems with “the problem with ‘magnitude-based inference”'. Med. Sci. Sports Exerc. 51:599. doi: 10.1249/MSS.0000000000001823
Boullosa, D. A., de Almeida, J. A., and Simoes, H. G. (2011). The two-hour marathon: how? J. Appl. Physiol. 110, 292–294. doi: 10.1152/japplphysiol.01265.2010
de Koning, J. J., Foster, C., Bakkum, A., Kloppenburg, S, Thiel, C., Joseph, T., et al. (2011). Regulation of pacing strategy during athletic competition. PLoS ONE 6:e15863. doi: 10.1371/journal.pone.0015863
Díaz, J. J., Fernández, E. J., and Santos-Concejero, J. (2018). The influence of pacing strategy on marathon world records. Eur. J. Sport Sci. 18, 781–786. doi: 10.1080/17461391.2018.1450899
Díaz, J. J., Fernández, E. J., Torres, M., and Santos-Concejero, J. (2019). Men vs. women world marathon records' pacing strategies from 1998 to 2018. Eur. J. Sport Sci. 19, 1297–1302. doi: 10.1080/17461391.2019.1596165
El Helou, N., Taffket, M., Berthelot, G., et al. (2012). Impact of environmental parameters on marathon running performance. PLoS ONE. 7:e37407. doi: 10.1371/journal.pone.0037407
Ely, M. R., Cheuvront, S. N., and Montain, S. J. (2007). Neither cloud cover nor low solar loads are associated with fast marathon performance. Med. Sci. Sports Exerc. 39, 2029–2035. doi: 10.1249/mss.0b013e318149f2c3
Ely, M. R., Martin, D. E., Cheuvront, S. N., and Montain, S. J. (2008). Effect of ambient temperature on marathon pacing is dependent on runner ability. Med. Sci. Sports Exerc. 40, 1675–1680. doi: 10.1249/MSS.0b013e3181788da9
Foster, C., deKoning, J. J., Hettinga, F., Lampen, J., Dodge, C., Bobbert, M., et al. (2004). Effect of competitive distance on energy expenditure during simulated competition. Int. J. Sports Med. 25, 198–204. doi: 10.1055/s-2003-45260
Foster, C., Schrager, M., Snyder, A. C., and Thompson, N. N. (1994). Pacing strategy and athletic performance. Sports Med. 17, 77–85. doi: 10.2165/00007256-199417020-00001
Foster, C., Snyder, A. C., Thompson, N. N., Green, M. A., Foley, M., and Schrager, M. (1993). Effect of pacing strategy on cycle time trial performance. Med. Sci. Sports Exerc. 25, 383–388. doi: 10.1249/00005768-199303000-00014
Haney, T. A., and Mercer, J. A. (2011). A description of variability of pacing in marathon distance running. Int. J. Exerc. Sci. 4, 133–140.
Hettinga, F. J., de Koning, J. J., Meijer, E., et al. (2007). Biodynamics. Effect of pacing strategy on energy expenditure during a 1500-m cycling time trial. Med. Sci. Sports Exerc. 39, 2212–2218. doi: 10.1249/mss.0b013e318156e8d4
Hoogkamer, W., Kram, R., and Arellano, C. J. (2017). How biomechanical improvements in running economy could break the 2-hour marathon barrier. Sports Med. 47, 1739–1750. doi: 10.1007/s40279-017-0708-0
Hopkins, W. G., Marshall, S. W., Batterham, A. M., and Hanin, J. (2009). Progressive statistics for studies in sports medicine and exercise science. Med. Sci Sports Exerc. 41, 3–13. doi: 10.1249/MSS.0b013e31818cb278
Joyner, M. J., Ruiz, J. R., and Lucia, A. (2011). The two-hour marathon: who and when? J. Appl. Physiol. 110, 275–277. doi: 10.1152/japplphysiol.00563.2010
Liu, Y., and Schutz, R. W. (1998). Prediction models for track and field performances. Meas. Phys. Educ. Exerc. Sci. 2, 205–223. doi: 10.1207/s15327841mpee0204_2
Maffetone, P. B., Malcata, R., Rivera, I., and Laursen, P. B. (2017). The Boston marathon versus the world marathon majors. PLoS ONE 12:e0184024. doi: 10.1371/journal.pone.0184024
Marc, A., Sedeaud, A., Guillaume, M., Rizk, M., Schipman, J., Antero-Jacquemin, J., et al. (2014). Marathon progress: demography, morphology and environment. J. Sports Sci. 32, 524–532. doi: 10.1080/02640414.2013.835436
March, D. S., Vanderburgh, P. M., Titlebaum, P. J., and Hoops, M. L. (2011). Age, sex, and finish time as determinants of pacing in the marathon. J. Strength Cond. Res. 25, 386–391. doi: 10.1519/JSC.0b013e3181bffd0f
Marino, F. E., Lambert, M. I., and Noakes, T. D. (2004). Superior performance of African runners in warm humid but not in cool environmental conditions. J. Appl. Physiol. 96, 124–130. doi: 10.1152/japplphysiol.00582.2003
Maughan, R. J., Watson, P., and Shirreffs, S. M. (2007). Heat and cold: what does the environment do to the marathon runner? Sports Med. 37, 396–399. doi: 10.2165/00007256-200737040-00032
Mehaffey, J. (2009). Do Pacemakers Have a Place in Athletics? Reuters. Retrieved from: http://blogs.reuters.com/sport/2009/04/28/do-pacemakers-have-a-place-in-athletics/ (accessed April 28, 2019).
Onywera, V. O., Scott, R. A., Boit, M. K., and Pitsiladis, Y. P. (2006). Demographic characteristics of elite Kenyan endurance runners. J. Sports Sci. 24, 415–422. doi: 10.1080/02640410500189033
Pugh, L. G. (1970). Oxygen intake in track and treadmill running with observations on the effect of air resistance. J. Physiol. 207, 823–835. doi: 10.1113/jphysiol.1970.sp009097
Rauch, H. G., Schönbächler, G., and Noakes, T. D. (2013). Neural correlates of motor vigour and motor urgency during exercise. Sports Med. 43, 227–241. doi: 10.1007/s40279-013-0025-1
Renfree, A., and Gibson, A. (2013). Influence of different performance levels on pacing strategy during the women's World Championship marathon race. Int. J. Sports Physiol. Perform. 8, 279–285. doi: 10.1123/ijspp.8.3.279
Renfree, R., Crivoi do Carmo, E., Martin, L., and Peters, D. M. (2015). The influence of collective behavior on pacing in endurance competitions. Front. Physiol. 6:373. doi: 10.3389/fphys.2015.00373
Roberts, W. O. (2010). Determining a “do not start” temperature for a marathon on the basis of adverse outcomes. Med. Sci. Sports Exerc. 42, 226–232. doi: 10.1249/MSS.0b013e3181b1cdcf
Sainani, K. L. (2018). The problem with “magnitude-based Inference”. Med. Sci. Sports Exerc. 50, 2166–2176. doi: 10.1249/MSS.0000000000001645
Sainani, K. L., Lohse, K. R., Jones, P. R., and Vickers, A. (2019). Magnitude-based Inference is not Bayesian and is not a valid method of inference. Scand. J. Med. Sci. Sports. 29, 1428–1436. doi: 10.1111/sms.13491
Skorski, S., and Abbiss, C. R. (2017). The manipulation of pace within endurance sport. Front. Physiol. 27:102. doi: 10.3389/fphys.2017.00102
Sousa, C. V., Sales, M. M., Nikolaidis, P. T., Rosemann, T., and Knechtle, B. (2018). How much further for the sub-2-hour marathon? Open Access J. Sports Med. 9, 139–145. doi: 10.2147/OAJSM.S169758
Tucker, R., and Noakes, T. D. (2009). The physiological regulation of pacing strategy during exercise: a critical review. Br. J. Sports Med. 43:e1. doi: 10.1136/bjsm.2009.057562
Venhorst, A., Micklewright, D., and Noakes, T. D. (2018). Towards a three-dimensional framework of centrally regulated and goal-directed exercise behaviour: a narrative review. Br. J. Sports Med. 52, 957–966. doi: 10.1136/bjsports-2016-096907
Weiss, M., Newman, A., Whitmore, C., and Weiss, S. (2016). One hundred and fifty years of sprint and distance running - Past trends and future prospects. Eur. J. Sport Sci. 16, 393–401. doi: 10.1080/17461391.2015.1042526
Keywords: long-distance running, endurance, athletics, tactics, pacing
Citation: Díaz JJ, Renfree A, Fernández-Ozcorta EJ, Torres M and Santos-Concejero J (2019) Pacing and Performance in the 6 World Marathon Majors. Front. Sports Act. Living 1:54. doi: 10.3389/fspor.2019.00054
Received: 26 June 2019; Accepted: 14 October 2019;
Published: 08 November 2019.
Edited by:
Stephane Bermon, International Association of Athletics Federations, MonacoReviewed by:
Geoffroy Berthelot, École Polytechnique, FranceThierry Stephane Bernard, Université de Toulon, France
Copyright © 2019 Díaz, Renfree, Fernández-Ozcorta, Torres and Santos-Concejero. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: José Joaquín Díaz, am9zZWpvYXF1aW5kaWF6bWFydGluJiN4MDAwNDA7Z21haWwuY29t