AUTHOR=Ambaye Abera Demeke , Mamo Melaku Dereje , Zigyalew Yaschelewal , Mengistu Wondimagegne M. , Fito Nure Jemal , Mokrani Touhami , Ntsendwana Bulelwa TITLE=The development of carbon nanostructured biosensors for glucose detection to enhance healthcare services: a review JOURNAL=Frontiers in Sensors VOLUME=5 YEAR=2024 URL=https://www.frontiersin.org/journals/sensors/articles/10.3389/fsens.2024.1456669 DOI=10.3389/fsens.2024.1456669 ISSN=2673-5067 ABSTRACT=

In this review, the forefront of biosensor development has been marked by a profound exploration of carbon nanostructured materials for the specific application of glucose detection. Moreover, this progressive line of inquiry capitalizes on the distinctive attributes of carbon nanostructured materials such as carbon nanotubes, carbon quantum dots, and graphene which exhibit unique characteristics in the development of biosensor engineering design. It also enhanced analytical performances regarding the limit of detection, selectivity, sensitivity, and reproducibility towards glucose detection in biological samples. Most importantly, the strategic integration of carbon nanostructured-based biosensor architectures has played a significant role in advancements, characterized by heightened sensitivity, exquisite selectivity, and augmented stability in glucose detection processes. Furthermore, utilizing these advanced materials has engendered a transformative impact on electrochemical properties, propelling the biosensors to achieve rapid and precise glucose-sensing capabilities. The confluence of carbon nanostructures with biosensor technology has not only elevated the scientific understanding of glucose detection mechanisms. Still, it has also paved the way for miniaturized and portable biosensors. This transformative shift holds great promise for the realization of point-of-care diagnostics, representing a pivotal step towards durability and efficient glucose monitoring in health/medical care. These advancements emphasize the crucial role of carbon nanostructured-based biosensors in opening the way to a new avenue of superiority and effectiveness in diabetes management. Conclusively, the challenges and, in a forward-looking stance, the prospective futures of glucose biosensors anchored on carbon nanostructured frameworks were considered.