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REVIEW article
Front. RNA Res.
Sec. RNA Processing and Regulation
Volume 3 - 2025 | doi: 10.3389/frnar.2025.1531242
This article is part of the Research Topic RNA Methylation: Detection, Deposition, and Functions View all 6 articles
The Role of m 6 A RNA Methylation in Infectious Diseases
Provisionally accepted- 1 Department of Zoology, Allahabad University, PRAYAGRAJ, India
- 2 Department of Chemistry, University of Allahabad, Prayagraj, India, Pryagraj, India
Among over 170 known RNA modifications, N 6 -methyladenosine (m 6 A) stands out as the most ubiquitous and extensively studied modification, found in different cellular RNA. The m 6 A plays a pivotal role in regulating RNA nuclear export, stability, secondary structure translation, and degradation eventually determining the gene expression. The m 6 A modification is controlled by three classes of enzymes: -writers‖, -erasers‖, and -readers‖ which not only play a role in adding and removing the methyl group but also help in recognizing and interpreting the methylation marks. Although m 6 A has been widely studied in the context of metabolic diseases and cancers, its influence on infectious diseases remains under-explored. The infection cycle of several pathogens, including viruses, bacteria, and parasites is regulated by the m 6 A methylation machinery. In this review, we will not only explore the existing knowledge about m 6 A methylation but also its influence in shaping the pathogen life cycle paving our way to therapeutic aspects to mitigate infectious disease.
Keywords: N 6 -methyladenosine (m 6 A), writers, Erasers, Readers, infectious diseases
Received: 20 Nov 2024; Accepted: 18 Mar 2025.
Copyright: © 2025 Kumari, Yadav, Khan and Goyal. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Rajesh Kumari, Department of Zoology, Allahabad University, PRAYAGRAJ, India
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