AUTHOR=Lingegowda Harshavardhan , Miller Jessica E. , Marks Ryan M. , Symons Lindsey K. , Alward Taylor , Lomax Alan E. , Koti Madhuri , Tayade Chandrakant TITLE=Synthetic Cannabinoid Agonist WIN 55212-2 Targets Proliferation, Angiogenesis, and Apoptosis via MAPK/AKT Signaling in Human Endometriotic Cell Lines and a Murine Model of Endometriosis JOURNAL=Frontiers in Reproductive Health VOLUME=3 YEAR=2021 URL=https://www.frontiersin.org/journals/reproductive-health/articles/10.3389/frph.2021.726936 DOI=10.3389/frph.2021.726936 ISSN=2673-3153 ABSTRACT=
Endometriosis (EM) is characterized by the growth of endometrium-like tissue outside the uterus, leading to chronic inflammation and pelvic pain. Lesion proliferation, vascularization, and associated inflammation are the hallmark features of EM lesions. The legalization of recreational cannabinoids has garnered interest in the patient community and is contributing to a greater incidence of self medication; however, it remains unknown if cannabinoids possess marked disease-modifying properties. In this study, we assess the effects of synthetic cannabinoid, WIN 55212-2 (WIN 55), in EM-representative