AUTHOR=Raheem Amr Abdel , Zaghloul Ahmed Said , Sadek Ahmed M. G. , Rayes Bilal , Abdel-Raheem Tarek M. 

TITLE=The Impact and Management of Gynaecomastia in Klinefelter Syndrome

JOURNAL=Frontiers in Reproductive Health

VOLUME=3

YEAR=2021

URL=https://www.frontiersin.org/journals/reproductive-health/articles/10.3389/frph.2021.629673

DOI=10.3389/frph.2021.629673

ISSN=2673-3153

ABSTRACT=<p>Gynecomastia is defined as a palpable enlargement of the male breast, secondary to an increase in the glandular and stromal breast tissue. Gynecomastia is encountered in up to 80% of Klinefelter syndrome cases. The pathophysiology involves testosterone/estrogen imbalance. This review article will further explore the pathophysiology of gynecomastia along with the different lines of management.</p>