AUTHOR=Oliveira Nayara Rodrigues Gomes de , Teixeira Gustavo Gonçalves , Fernandes Kathlen Terezinha Montes Soares , Avelar Marla Moreira , Medeiros Maja , Formiga Cibelle Kayenne Martins Roberto TITLE=Therapeutic hypothermia as a neuroprotective strategy in newborns with perinatal asphyxia—case report JOURNAL=Frontiers in Rehabilitation Sciences VOLUME=4 YEAR=2023 URL=https://www.frontiersin.org/journals/rehabilitation-sciences/articles/10.3389/fresc.2023.1132779 DOI=10.3389/fresc.2023.1132779 ISSN=2673-6861 ABSTRACT=Background

Perinatal asphyxia is a public health problem and the third major cause of death among children under 5 years.

Objective

Two clinical cases of newborns with perinatal asphyxia submitted to therapeutic hypothermia and the follow-up of their motor development after hospital discharge have been reported.

Methods

This retrospective case report study included two newborns with hypoxic-ischemic encephalopathy due to perinatal asphyxia who received a hypothermia protocol at the neonatal intensive care unit (NICU). The two newborns and their families were followed up at the outpatient clinic and assessed using the Hammersmith Child Neurological Examination, Alberta Child Motor Scale, and Denver Developmental Screening Test-II.

Results

The newborns were submitted to a 72-hour hypothermia protocol. One newborn remained for 13 days in the NICU, while the other remained for 22 days. According to the multidisciplinary team, both cases presented with typical motor development with no cerebral palsy during the follow-up.

Conclusion

Both cases showed positive results and a good prognostic for motor development. Therapeutic hypothermia may be a strategy to prevent neurologic sequelae in newborns with perinatal asphyxia, including cerebral palsy.