Prevalence and burden of HBV-HIV Co-morbidity: Global Systematic Review and Meta-analysis

Mequanente Dagnaw ^* Lemma Derseh Gezie Achenef Asmamaw Muche Bisrat Misganaw Geremew

• Institute of Public Health, University of Gondar, Gondar, Ethiopia

Introduction: Hepatitis B is a serious liver infection caused by the hepatitis B virus (HBV).Because of the shared modes of transmission, co-infections of HBV are common with people living with Human Immunodeficiency Virus (HIV) infection. While the use of antiretroviral therapy (ART) has significantly improved the life expectancy of HIV patients, hepatitis viral co-infections have become increasingly important. Particularly, HBV infection remains under-diagnosed and under-reported, despite its high infectious nature. Therefore, this review was amid to understand the bburden of Hepatitis B disease among adult living with HIV receiving ART.Methods: Using pertinent search terms, all research found in Google Scholar, HINARI, EMBAS, Scopus, and PubMed was located. Following the evaluation of the evidence with the Joanna Briggs Institute methodology for cross-sectional and cohort studies, data were extracted.Result: A total of eighteen research involving, 71411 people living with HBV-HIV adults were selected for study. Of those, 10.21% with 95% CI (5.06, 15.36) & 11.05% with 95% CI (2.78, 19.32) of HBV-HIV adults in world had an overall prevalence of HBV, with an I 2 value of 0.0 % (p-value=0.729) and an I 2 value of 0.0 % (p-value = 0.818) from cross sectional and cohort studies respectively.World has a high pooled prevalence of people living with HBV-HIV, which poses a serious risk to public health.The review can clearly show the current pooled prevalence of HIV-HBV in the world that might be helpful for policymakers because a big number of recent studies were included in it. Thus, it is strongly advised to expand the current preventive and control program's purview and implement new, sensitive screening, testing and treatment techniques. To raise community awareness, it would also be preferable to revamp the current prevention and control program and establish target-specific task forces at various health facility levels.