
94% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
MINI REVIEW article
Front. Public Health
Sec. Infectious Diseases: Epidemiology and Prevention
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1565242
This article is part of the Research Topic Challenges in reaching the UNAIDS 95-95-95 targets in Sub-Saharan Africa: Status, innovations, and pathways forward View all 8 articles
The final, formatted version of the article will be published soon.
You have multiple emails registered with Frontiers:
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Despite a significant reduction in the global HIV disease prevalence in recent years, children under 15 years of age still account for 3% of people living with HIV, 9% of new incidence and 12% of AIDS-related deaths. Although there is increased access and use of antiretroviral drugs, children under 1 year in resource poor settings with a high HIV disease burden remain vulnerable due to poor initiation of these critical interventions impeding progress to meet the 95-95-95 targets. There are renewed efforts to ensure that exposed children under 15 years are not left behind by scaling diagnostics and clinical management in the most affected communities. However, gaps remain in the integration of these services in maternal, child and adolescent healthcare services within these communities, resulting in only 67% of HIV exposed infants being tested within 2 months of birth, globally in 2023. Consequently, only 29% of all exposed children under 15 years were initiated in antiretroviral treatment before their 5th birthday in 2023. There are successes in adults aged 15 years and above, but children under 15 years risk being left behind in achieving the 95-95-95 targets. Here we review efforts made to reduce these substantial regional variations when comparing progress made between children under 15 years and adults and highlight gaps that might impede achievement of the 95-95-95 targets among children.
Keywords: Children, HIV, 95-95-95 HIV/AIDS Goals, Challenges, Africa
Received: 22 Jan 2025; Accepted: 07 Apr 2025.
Copyright: © 2025 Kulohoma and Wesonga. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Benard W Kulohoma, IAVI Africa, Nairobi, Kenya
Colette S.A. Wesonga, Ortholog, Nairobi, Kenya
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Research integrity at Frontiers
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.