95% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
ORIGINAL RESEARCH article
Front. Public Health
Sec. Children and Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1563305
This article is part of the Research Topic Children's Health and Screen Time View all 8 articles
Prediction of myopia based on biometric parameters of 500,000 children and adolescents aged 3-18 years
Provisionally accepted- Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
Purpose To explore the validity and significance of the axial length/corneal radius (AL/CR) Ratio for myopia prediction in children of all ages.Methods Between 2020 and 2022, 509,530 children and adolescents aged 3-18 years were sampled in Chengdu City, Sichuan Province, China, by whole-cluster sampling method. Measured their uncorrected visual acuity(UCVA), non-cycloplegic autorefraction, axial length (AL), and corneal radius (CR), Pearson's correlation coefficient and Receiver operating characteristic (ROC) curve were used to determine the accuracy and calculate the cutoff for myopia detection. Results The correlation between AL/CR ratio and SE was higher than that between AL and SE at different ages and refractive states. The area under the ROC curve (AUC) of myopia detection by AL/CR ratio(0.9112) was signifcantly larger than that of AL (0.8923,P<0.001), The difference between boys and girls using AL/CR ratio to detect myopia was also statistically significant (p<0.001). The cutoffs for predicting myopia by AL/CR ratio increased with age, from >2.755 in 3-year-old to> 3.095 in 18-year-old, with boys increasing from >2.755 to >3.095 , and girls from >2.715 to >3.085, and the cutoff for boys was higher than that for girls at the same age. Conclusion Different cutoff for AL/CR ratio can be used to predict myopia for children and adolescents of different ages and genders, and this method can be widely used for clinical diagnosis and mass myopia screening.
Keywords: Children, Myopia, axial length/corneal radius ratio, Cutoff value, Axial length
Received: 19 Jan 2025; Accepted: 31 Mar 2025.
Copyright: © 2025 Chen, Mu, Tan, Wu and Duan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Junguo Duan, Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.