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ORIGINAL RESEARCH article
Front. Public Health
Sec. Environmental Health and Exposome
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1555731
This article is part of the Research Topic Understanding the Link Between Environmental Pollutants, Brain & Behavior View all 7 articles
Association between Organophosphate Pesticide Exposure and Atopic Dermatitis: A Cross-sectional Study Based on NHANES 1999-2007
Provisionally accepted- 1 Peking University Third Hospital, Haidian, China
- 2 National Health Commission Key Laboratory of Medical Immunology, Department of Immunology, School of Basic Medical Sciences, Health Science Centre, Peking University, Beijing, Beijing Municipality, China
Background: Organophosphate pesticides (OPPs) are widely used environmental chemicals with potential health impacts, but their relationship with atopic dermatitis (AD) remains unclear.Methods: Using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2007, we investigated associations between urinary OPP metabolites and AD in 4,258 adults. Six dialkyl phosphate (DAP) metabolites were measured, and weighted quantile sum (WQS) regression was used to assess mixture effects.Results: Both DMP (odds ratio [OR]=1.17, 95% confidence interval [CI]: 1.05-1.31) and DMDTP (OR=2.23, 95%CI: 1.08-4.60) showed significant positive associations with AD in fully adjusted models. WQS regression revealed significant associations between mixed OPP exposure and AD (OR=1.25, 95%CI: 1.04-1.50), with DMP contributing most (45.8%) to the mixture effect. Stratified analyses indicated stronger associations in males, younger adults (<60 years), and smokers. Conclusions: Our findings suggest that OPP exposure, particularly DMP, may be associated with increased AD risk in adults. These results provide new insights into environmental risk factors for AD.
Keywords: organophosphate pesticides, atopic dermatitis, NHANES, Environmental Exposure, Dialkyl phosphate metabolites, Epidemiology
Received: 05 Jan 2025; Accepted: 20 Feb 2025.
Copyright: © 2025 Men, Wang, Wu and Chu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yuehua Men, Peking University Third Hospital, Haidian, China
Ming Chu, National Health Commission Key Laboratory of Medical Immunology, Department of Immunology, School of Basic Medical Sciences, Health Science Centre, Peking University, Beijing, 100191, Beijing Municipality, China
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