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SYSTEMATIC REVIEW article
Front. Public Health
Sec. Public Mental Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1554195
Move your body, stay away from depression: a systematic review and Meta-analysis of exercise-based prevention of depression in middle-aged and older adults
Provisionally accepted- 1 Kyonggi University, Suwon, Republic of Korea
- 2 Northwest Normal University, Lanzhou, Gansu, China
This study aimed to systematically assess the efficacy of exercise interventions in preventing depression among middle-aged and older adults. It further sought to dissect the impact of various intervention factors on the exercise-depression nexus within this demographic.We conducted a comprehensive search across multiple databases including PubMed, Embase, Web of Science, and the Cochrane Library, spanning from their inception through April 2024. The initial search yielded several studies, from which 11 papers involving a total of 792 subjects were selected based on predetermined inclusion criteria.Results: Our meta-analysis revealed a significant overall effect size (SMD = -3.64) with a 95% confidence interval of [-4.81, -2.48] and a p-value of <0.00001, underscoring the potent preventative impact of exercise on depressive symptoms in the target population. However, the studies exhibited substantial heterogeneity (I² = 87%).functional training, significantly reduce the risk of depression among middle-aged and older adults. The most pronounced effects were observed in group exercise settings and with exercise sessions lasting 30-40 minutes. Interventions of medium duration generally outperformed shorter-term interventions. Despite these promising results, the observed heterogeneity and other potential study limitations suggest a need for further research involving larger samples and more comprehensive study designs to refine and optimize exercise protocols for depression prevention in this population.
Keywords: Depression, Elderly, Exercise, prevent, Meta-analysis
Received: 01 Jan 2025; Accepted: 24 Feb 2025.
Copyright: © 2025 Zhao, Oh, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chong Wang, Northwest Normal University, Lanzhou, 730070, Gansu, China
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