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ORIGINAL RESEARCH article
Front. Public Health
Sec. Aging and Public Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1548222
This article is part of the Research Topic Enhancing Geriatric Care: International Collaboration and Best Practices for Aging Populations View all 11 articles
Investigation of the association between the triglycerideglucose index and the incidence of frailty among middleaged and older adults: Evidence from the China Health and Retirement Longitudinal Study
Provisionally accepted- 1 Nursing Department, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
- 2 Nursing Department, North Sichuan Medical College, Nanchong, Sichuan Province, China
Limited researches have investigated the association between the Triglyceride-glucose index (TyG) and frailty vulnerability in middle-aged and older Chinese populations. This study aims to strengthen the scientific foundation for frailty prevention and management by analyzing the correlation between TyG and frailty, ultimately providing more targeted intervention strategies.This study included middle-aged and older individuals who participated in the China Health and Retirement Longitudinal Study (CHARLS) from 2015. A multiple logistic regression model was constructed to assess the correlation between the TyG index and frailty. Additionally, restricted cubic spline (RCS) analysis was employed to evaluate the dose-response correlation between the two variables.Among the 3,978 participants included in the study, 667 individuals (16.8%) were identified with frailty. After adjusting for multiple factors in a logistic regression model, it was determined that individuals in the highest quartile group of the TyG index had a 1.43 times higher risk of frailty compared to those in the lowest quartile group (OR=1.43,95% CI: 1.10~1.85, P=0.007).The RCS analysis further revealed a positive dose-response relationship, indicating that a higher TyG index was associated with an increased risk of frailty in middle-aged and older adults.Research has shown a significant positive linear relationship between an increased TyG index and a higher prevalence of frailty in middle-aged and older individuals. Elevated TyG index levels could signal an increased vulnerability to frailty among individuals.
Keywords: Frailty, CHARLS, age, triglycerides-glucose index, Frail older adults
Received: 19 Dec 2024; Accepted: 02 Apr 2025.
Copyright: © 2025 Long, Li, Shi, Mao and Lee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lifang Mao, Nursing Department, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
Yujun Lee, Nursing Department, North Sichuan Medical College, Nanchong, Sichuan Province, China
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