REVIEW article
Front. Public Health
Sec. Infectious Diseases: Epidemiology and Prevention
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1544220
This article is part of the Research TopicAdvancements in HPV Research: Integrating Diagnostics, Vaccination, and Women's HealthView all articles
Optimizing HPV Vaccine Effectiveness: Impact of Vaccination Age and Dose Schedule on Immunogenicity and Cervical Cancer Prevention Effectiveness of the HPV Vaccine on the Age at Vaccination and the Number of Doses: A Review Article
Provisionally accepted
- 1Shahid Beheshti University of Medical Sciences, Tehran, Iran
- 2Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Tehran, Iran
- 3Student Research Committee, Saveh University of Medical Sciences, Saveh, Iran, saveh, Iran
- 4Assistant Professor, Department of Public Health. Saveh University of Medical Sciences, Saveh, Iran, saveh, Iran
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Cervical cancer is the fourth most common cancer among women globally, claiming over 443,000 lives annually, with 98% of these deaths occurring in developing countries. Vaccination against human papillomavirus (HPV) is a preventive strategy. This review investigates the role of age at vaccination and the number of doses in determining vaccine effectiveness. Articles from 2013--2023 were retrieved from PubMed, Scopus, SID, and Google Scholar via using keywords related to HPV, vaccine, age, and dose. The findings suggest that the highest vaccine effectiveness is observed in younger age groups (ages 9-14: 74-93%) and decreases with age. Studies indicate that while three doses provide optimal protection, a single dose may also confer significant benefits in younger populations.These findings underscore the importance of timely vaccination and adherence to dosing schedules for maximizing vaccine impact.
Keywords: vaccine efficacy, Dose optimization, Public Health, HPV, cervical cancer Formatted: Highlight Formatted: Font: 16 pt, Complex Script Font: 16 pt, Formatted: Left-to-right
Received: 12 Dec 2024; Accepted: 22 Apr 2025.
Copyright: © 2025 Rostami, Khoshnazar, Zeraie and Hosseini Koukamari. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Parisa Hosseini Koukamari, Assistant Professor, Department of Public Health. Saveh University of Medical Sciences, Saveh, Iran, saveh, Iran
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.