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ORIGINAL RESEARCH article
Front. Public Health
Sec. Environmental Health and Exposome
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1544174
Relationship between the level of mixed chemicals in male urine and the prevalence of male cancers, especially prostate cancer
Provisionally accepted- 1 Binhai County People's Hospital, Yancheng, China
- 2 Shandong Tumor Hospital, Jinan, Shandong Province, China
- 3 Cardiovascular Diseases Center, Xiyuan Hospital, Beijing, China
The aim of this study was to investigate the relationship between mixed chemicals in urine and the prevalence of cancers in men.Methods: A total of 1068 male subjects were included in this study. Analyses were performed by several analytical methods to ensure the stability of the results: one-way analysis, WQS analysis, Qgcomp analysis, BKMR analysis, and Restricted Cubic Spline (RCS).In the final adjusted model, each 1 increase in ln-transformed BPS increased the risk of developing cancerous prostate by 49% (95% CI:1.00-2.20). The results of multiple sensitivity analyses by WQS and Qgcomp showed that the mixed chemicals was positively correlated with the prevalence of cancers and prostate cancer in men. In the final adjusted model, each quartile increase in the WQS index was associated with a 78% (OR:1.78,95% CI:1.10-2.87) increase in the risk of cancers and a 148% (OR:2.48,95% CI:1.07-5.71) increase in the risk of prostate cancer. Each quartile increase in the Qgcomp index was associated with a 59% (OR:1.59,95% CI:1.09-2.33) increase in the risk of cancers, and a 105% (OR:2.05,95% CI:1.04-4.06) increase in the risk of prostate cancer.In conclusion, this study showed a positive correlation between the concentrations of the three groups of mixed chemicals in urine and the prevalence of cancers in men, as well as a positive correlation with the prevalence of prostate cancer.
Keywords: Cancers, NHANES, Men, Prostate, Mixed Chemicals, Urine 1.Introduction
Received: 12 Dec 2024; Accepted: 21 Feb 2025.
Copyright: © 2025 Zhang, Sun, Zhu, Wang, Zuo and Dai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiuming Dai, Binhai County People's Hospital, Yancheng, China
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