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STUDY PROTOCOL article

Front. Public Health
Sec. Occupational Health and Safety
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1531546
This article is part of the Research Topic Advances in Radiation Research and Applications: Biology, Environment and Medicine View all 6 articles

Low-dose ionizing radiation and the exposure-lag response: protocol for a prospective cohort study on The Health Effects of Chongqing Occupational Radiation Workers (THECORW)

Provisionally accepted
Xiao-Ling Qin Xiao-Ling Qin 1*Qiang Huang Qiang Huang 2*Han-Wen Zhang Han-Wen Zhang 3*Yi Zeng Yi Zeng 1Xian-Shu Lin Xian-Shu Lin 1*Xiao-Yuan Fan Xiao-Yuan Fan 1*Jun Diao Jun Diao 4*Cheng-Zhi Chen Cheng-Zhi Chen 1Shu-Qun Cheng Shu-Qun Cheng 1Jun-Lin He Jun-Lin He 1Wei Li Wei Li 2*Yin-Yin Xia Yin-Yin Xia 1*
  • 1 Chongqing Medical University, Chongqing, China
  • 2 Chongqing Center for Disease Control and Prevention, Chongqing, Chongqing, China
  • 3 First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing Municipality, China
  • 4 Chongqing Jiulongpo District Center for Disease Control and Prevention, jiulongpo, Chongqing, China

The final, formatted version of the article will be published soon.

    Introduction Although the effects of ionizing radiation on radiation workers have been extensively studied in China, no prospective cohort study has been conducted in Chongqing. Furthermore, previous cohorts have not provided a broad-gauge assessment of the temporal relationship between low-dose occupational radiation exposure and the risk of health outcomes.Methods A prospective cohort study will be carried out focusing on radiation workers in Chongqing.Health examination outcomes and radiation dose monitoring data will be collected and analyzed using the distributed lag non-linear model (DLNM) combined with generalized additive model (GAM) or generalized linear model (GLM) to evaluate the exposure-lag response relationship.Discussion Our study will enhance our understanding of the exposure-lag response association between occupational radiation exposure and the health of radiation workers based on DLNM.

    Keywords: ChiCTR2400081804 Radiation workers, Low-dose ionizing radiation, Exposure-lag response, cohort, Distributed lag non-linear model, Radiation workers

    Received: 20 Nov 2024; Accepted: 14 Jan 2025.

    Copyright: © 2025 Qin, Huang, Zhang, Zeng, Lin, Fan, Diao, Chen, Cheng, He, Li and Xia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiao-Ling Qin, Chongqing Medical University, Chongqing, China
    Qiang Huang, Chongqing Center for Disease Control and Prevention, Chongqing, 400042, Chongqing, China
    Han-Wen Zhang, First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, Chongqing Municipality, China
    Xian-Shu Lin, Chongqing Medical University, Chongqing, China
    Xiao-Yuan Fan, Chongqing Medical University, Chongqing, China
    Jun Diao, Chongqing Jiulongpo District Center for Disease Control and Prevention, jiulongpo, Chongqing, China
    Wei Li, Chongqing Center for Disease Control and Prevention, Chongqing, 400042, Chongqing, China
    Yin-Yin Xia, Chongqing Medical University, Chongqing, China

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