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ORIGINAL RESEARCH article
Front. Public Health
Sec. Children and Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1526832
This article is part of the Research Topic Exploring the Interconnection: Obesity's Role in Asthma Development and Management View all 3 articles
Interaction between obesity and asthma in children and adolescents with hypertension based on NHANES 2007-2020
Provisionally accepted
Yizhe Ma 1
Luchun Wang 1 Mingyan Tao 1
ZHI-DAN BAO 1
Renqiang Yu 2 Guihua Liu 1 Jing Liu 1*
Hu Li 1*- 1 Jiangyin People's Hospital of Nantong University, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
- 2 Wuxi Maternity and Child Health Care Hospital, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, China
Objectives: This study aims to elucidate the relationship between obesity and asthma in children and adolescents with hypertension based on the 2007-2020 National Health and Nutrition Examination Survey (NHANES).Methods: Weighted logistic regression models assessed obesity and asthma's effects on hypertension risk, reported as odds ratio (OR) and 95% confidence interval (CI).Results: A cross-sectional analysis of 10,838 NHANES individuals aged 8-17 found 630(5.81%) had hypertension, with significant differences in age, sex, poverty-to-income ratio, low birth weight, presence or absence of obesity and asthma, triglyceride concentration, fasting glucose concentration, and tobacco exposure compared to those without hypertension (P < 0.05). After adjusting for all covariates, children and adolescents with obesity or asthma had a higher risk of hypertension (obesity: adjusted OR 2.144, 95% CI 1.688-2.723; asthma: adjusted OR 1.430, 95% CI 1.055-1.939). Individuals with both obesity and asthma showed a significantly higher risk of hypertension compared to those without these conditions (adjusted OR 2.876, 95% CI 1.892-4.372) (P < 0.001). The synergistic effect of childhood obesity and asthma on hypertension risk remained robust after the stratified subgroup analysis based on age, sex, birth weight, and tobacco exposure.This study demonstrates that obesity and asthma exert a synergistic effect on childhood hypertension, emphasizing the need for comprehensive interventions targeting weight management and asthma control. There is a pressing need for future research to delve deeper into the mechanisms underlying the interactions between childhood asthma, obesity, and hypertension.
Keywords: Asthma, Obesity, Hypertension, Children, NHANES
Received: 12 Nov 2024; Accepted: 07 Apr 2025.
Copyright: © 2025 Ma, Wang, Tao, BAO, Yu, Liu, Liu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jing Liu, Jiangyin People's Hospital of Nantong University, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, China
Hu Li, Jiangyin People's Hospital of Nantong University, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, China
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