ORIGINAL RESEARCH article
Front. Public Health
Sec. Health Economics
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1514501
Health economic evaluation of EV71 vaccination in children under the school-age population in Guangdong Province, China
Provisionally accepted
Hui Zhang1jienan Zheng1
Danxia Luo1*
Steven Zeng2Yao Yi2Fen Yang2Lilin Lin2Aiping Deng2
Min Kang2Yingtao Zhang2*- 1Guangdong Pharmaceutical University, Guangzhou, China
- 2Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
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Background: This study aims to evaluate the health economics of hand-foot-mouth disease enterovirus 71 (EV71) vaccination for the population of appropriate age in Guangdong Province.Methods: A SEIR model was constructed, and a group of differential equations was established. The incidence data of HFMD in Guangdong from January to June 2017 were used to fit the model and the basic reproduction value(R0) of this disease was simulated. Then, the incidence of HFMD under different vaccination coverage rate(0%, 40%, 70%, 90%) was simulated in four scenarios. Cost-effectiveness analysis was used to evaluate the health economics.Results: The self-funded voluntary EV71 vaccination strategy implemented in Guangdong Province has effectively reduced the disease economic burden of EV71-type HFMD, and the disease economic burden saved during the peak seasonal segment of HFMD in 2017 was $1,080,000. Meanwhile, Scenario 2, 3, and 4 would each result in a cumulative reduction of 6,525, 9,556, and 10,989 confirmed cases, respectively, with
Keywords: Hand, Foot and Mouth Disease, EV71 vaccine, Health economics evaluation, Vaccine, EV71
Received: 21 Oct 2024; Accepted: 23 Apr 2025.
Copyright: © 2025 Zhang, Zheng, Luo, Zeng, Yi, Yang, Lin, Deng, Kang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Danxia Luo, Guangdong Pharmaceutical University, Guangzhou, China
Yingtao Zhang, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.