POLICY BRIEF article

Front. Public Health, 21 March 2025

Sec. Public Health Education and Promotion

Volume 13 - 2025 | https://doi.org/10.3389/fpubh.2025.1514090

This article is part of the Research TopicEnsuring Public Health: The Active Role of Healthcare ProfessionalsView all 9 articles

A multi-level approach to reduce exploding type 2 diabetes in Pakistan

Fazal Jamil
Fazal Jamil1*Umaima MirUmaima Mir2Anum G. NiaziAnum G. Niazi3Shandana KifayatShandana Kifayat4Shanlina KifayatShanlina Kifayat5Sobia ShafiqSobia Shafiq6Zeeshan WaliZeeshan Wali7Muhammad Ali Jan KhanMuhammad Ali Jan Khan8Baber WaliBaber Wali9Khadija Tul KobraKhadija Tul Kobra10Muhammad Salar KhanMuhammad Salar Khan11
  • 1St. Elizabeth Youngstown Hospital, Youngstown, OH, United States
  • 2Lady Reading Hospital, Peshawar, Pakistan
  • 3Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States
  • 4Khyber Teaching Hospital, Khyber Medical University, Peshawar, Pakistan
  • 5Lady Reading Hospital, Peshawar, Pakistan
  • 6Peshawar Dental College, Peshawar, Pakistan
  • 7Ayub Medical College, Abbottabad, Pakistan
  • 8College of Physical Medicine and Rehabilitation Paraplegic Center, Khyber Medical University, Peshawar, Pakistan
  • 9Cadet College Swat, Gulibagh, Pakistan
  • 10Islamia College University, Peshawar, Pakistan
  • 11Rochester Institute of Technology, Rochester, NY, United States

Pakistan has the third-highest rate of type 2 diabetes globally, following China and India, making this a significant public health crisis. Despite the severity of the issue, efforts from health and policy practitioners to address it remain limited. With millions already diagnosed as pre-diabetic, the rising incidence of diabetes is rapidly becoming a public health emergency that demands immediate attention. This policy brief provides an accessible overview of diabetes, focusing on its types, mechanisms, and preventive measures. It also identifies key contributing factors, such as dietary habits, obesity, physical inactivity, and the influence of modern dietary trends, while proposing strategies for individuals, communities, and policymakers to combat this growing epidemic in Pakistan. The brief emphasizes the need for a multi-level approach that includes public awareness, education, behavioral and dietary changes, and policy interventions to reverse the trend. Strategies discussed include promoting healthy eating, increasing physical activity, managing obesity, and enhancing access to affordable, healthy food. Additionally, the brief highlights the importance of community and government support, such as public health campaigns, infrastructure improvements, and legislative efforts. By adopting this comprehensive approach, Pakistan can take meaningful steps to address the diabetes epidemic and improve public health outcomes.

1 Introduction

According to the International Diabetes Federation Diabetes Atlas, Pakistan has the third-highest rate of type 2 diabetes among adults globally, after China and India, making it a growing crisis in the country (1). Furthermore, with an estimated prevalence of 33.6% among individuals aged 20–79, Pakistan now holds the highest global ranking for type 2 diabetes (2). Despite these alarming figures, health and policy practitioners have made limited efforts to address the issue, leaving the country vulnerable to an escalating public health crisis. The situation is even more concerning, with millions already diagnosed as pre-diabetic (3). The rising incidence of diabetes is rapidly becoming a public health emergency that requires immediate attention.

To combat this epidemic, a comprehensive, multi-level approach is necessary, which would cover individual to communal and government level efforts. Our team contends that such an approach would be most effective if it included public awareness, education, outreach, behavioral and dietary changes, along with policy interventions.

This policy brief provides an accessible overview of diabetes, including its types, causes, and preventive measures. It also explores the increasing prevalence of diabetes in Pakistan, identifies contributing factors, and outlines strategies for individuals, communities, and public health authorities to effectively prevent and manage the disease within the country. As this policy brief is aimed at raising public awareness and stimulating policy and community conversations around this critical public health issue in Pakistan, we draw on relevant literature while also relying on our expertise and background to offer suggestions, which aligns with the journal’s scope for this collection.1 To sustain public interest and to convey our message in plain language, we have deliberately minimized the use of dense academic citations and heavy medical jargon.

2 Diabetes: types, mechanisms, and factors

Diabetes is a chronic medical condition marked by elevated blood sugar levels (hyperglycemia) due to impaired insulin action, insufficient insulin production, or both. Insulin, a hormone produced by the beta cells in the pancreas, facilitates the uptake of glucose from the bloodstream into muscle and other body cells for energy (4).

Among the two primary types of diabetes (type 1 and type 2), type 1 diabetes is an autoimmune disorder in which the body’s immune system destroys insulin-producing beta cells in the pancreas, leading to little or no insulin production (5). In contrast, type 2 diabetes is primarily characterized by insulin resistance and progressive pancreatic beta-cell dysfunction, resulting in relative insulin deficiency and subsequent hyperglycemia (6, 7).2

Hyperglycemia in diabetic patients contributes to cardiovascular complications, kidney dysfunction, and oxidative stress, as well as metabolic dysregulation, which, in turn leads to increased appetite. Several factors contribute to the development of insulin resistance in type 2 diabetes, with obesity, genetics, and environmental and lifestyle factors playing significant roles.

Obesity, particularly visceral fat, is a major contributor to insulin resistance (8). In obese individuals, adipose (fat) tissue releases various biochemical substances (cytokines and hormones) that trigger inflammation and interfere with insulin signaling pathways, leading to insulin resistance. Simply put, excess fat can disrupt normal metabolism by causing inflammation and making it harder for the body to use insulin properly.

Genetics is another determinant for insulin resistance.3 Studies have identified several genetic variants that predispose individuals to impaired insulin signaling, beta-cell dysfunction, and altered glucose metabolism (8). These genetic factors may explain why some individuals develop insulin resistance despite having a normal body weight, while others remain metabolically healthy despite obesity. Inherited predispositions also influence how efficiently the body processes insulin and regulates blood sugar levels, affecting the risk of developing type 2 diabetes.

Beyond genetics and obesity, insulin resistance also develops gradually due to various environmental and lifestyle factors, with dietary habits playing a significant role (9). Overconsumption of refined sugars, processed grains, and high-glycemic carbohydrates results in frequent spikes in blood sugar levels. In response, the body produces excess insulin to manage these sugar spikes. Persistent overproduction of insulin causes the body to become less responsive, or more resistant, to it. Furthermore, this ongoing cycle of elevated blood sugar and excess insulin release leads to dysfunction in insulin-producing cells, ultimately resulting in diabetes. Physical inactivity, poor sleep, and chronic stress further contribute to insulin resistance by altering hormonal balance, inflammatory responses, and glucose metabolism.

3 Type 2 diabetes in Pakistan: causers and mitigators

Both types of diabetes are important to consider, but in Pakistan, the focus is primarily on type 2 diabetes due to its higher prevalence and preventable nature. According to recent estimates, Pakistan has one of the highest rates of diabetes in the world, with an estimated 33 million adults living with the condition (1).

The rise in diabetes cases in Pakistan can be attributed to three major cultural changes: increased consumption of refined sugars and processed grains, reduced physical activity paired with increased screen time, and more frequent eating and snacking. Western dietary influences have introduced more sugary and processed foods into the Pakistani diet, facilitated by the rapid growth of fast-food restaurants—a trend similar to nutritional shifts seen in other low and middle income countries (LMICs) (10). Moreover, traditional staples such as high-glycemic bread and rice continue to contribute to excessive carbohydrate intake. Decreased physical activity, coupled with more sedentary lifestyles, has further exacerbated the situation by lowering insulin sensitivity and increasing fat storage.

Frequent eating and snacking on unhealthy food may also contribute to the rising incidence of diabetes in Pakistan. While the scientific link between meal frequency and insulin resistance is still being studied, some research suggests that among women who eat breakfast irregularly, meal frequency is associated with a significantly higher risk of developing type 2 diabetes (11). Other studies indicate that frequent meal may contribute to higher BMI (and, by extension, obesity) (12), both of which are major risk factors for insulin resistance.

A critical factor in Pakistan’s diabetes epidemic is central obesity, which is highly prevalent, affecting over 70% of the Pakistani population (13). Excess visceral fat not only contributes to insulin resistance but also promotes chronic inflammation, further accelerating metabolic dysfunction (14). Given this strong link between obesity and diabetes, managing weight effectively is essential to reducing diabetes risk.

Research has consistently shown that weight reduction interventions are among the most effective strategies for preventing type 2 diabetes. The Diabetes Prevention Program (DPP) and similar studies have demonstrated that even modest weight loss (5–10% of body weight) can significantly improve insulin sensitivity and reduce diabetes risk (15). Comprehensive lifestyle interventions, including caloric restriction, increased physical activity, and nutritional counseling, have proven successful in weight management and diabetes prevention efforts (16).

Beyond weight management, insulin resistance itself can be reversed through targeted lifestyle changes. These include reducing the intake of refined sugars and processed grains, focusing on whole foods with low glycemic indices, limiting snacking and incorporating intermittent fasting. While intermittent fasting primarily aids in weight loss, emerging research suggests it may also enhance metabolic flexibility and reduce inflammation (17, 18), both of which play a role in diabetes prevention. Restricting eating to an 8-h window has also been associated with lower insulin levels and improved glucose metabolism (19).

Regular physical activity is equally crucial in this effort. Exercise, particularly after meals, has been shown to improve insulin sensitivity and helps muscles absorb and utilize blood sugar more efficiently (20).

To address the diabetes epidemic in Pakistan, comprehensive public health strategies are vital. Nationwide programs should be implemented to educate the public about healthy eating, weight management, and the risks associated with refined sugars and processed foods. Promoting physical activity through community programs, as well as initiatives in schools and workplaces, is equally important. Enhancing access to affordable, healthy food options—especially in urban areas where sedentary lifestyles and processed foods are more common—can have a significant impact. Additionally, regular screenings for prediabetes and diabetes are crucial for early detection and management.

4 Multi-level approach

Addressing the diabetes crisis in Pakistan requires a unified effort at multiple levels, including individuals, communities, and policymakers (see Table 1 for more details). By adopting such a multi-level approach that encourages informed lifestyle changes and the implementation of effective public health strategies, we propose it is possible to reverse the trend and mitigate this growing health crisis.

Table 1
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Table 1. A multi-level approach to reduce diabetes in Pakistan.

Table 1 outlines three types of interventions: individual, community, and policymaker interventions. These interventions primarily work synchronously and interdependently. For example, individuals depend on community support, and communities rely on individual participation for the successful implementation of many interventions. Similarly, policymaker support is crucial for both communities and individuals to carry out some of these interventions. This relationship is illustrated in Figure 1.

Figure 1
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Figure 1. Multi-level interventions to combat diabetes in Pakistan.

Now let us briefly explain the interventions this multi-level approach may entail at various levels in the following paragraphs.

4.1 Individual-level interventions

At the individual level, tackling diabetes begins with lifestyle changes (21) and behavioral adjustments (20), as also supported by studies from the Diabetes Prevention Program (DPP) (Diabetes Prevention Program Group, 2002). Reducing screen time and opting for alternative activities, such as outdoor games or family engagements, can help individuals become more active, thereby reducing the risk of type-2 diabetes (22). Dietary changes are crucial as well (23): swapping sugary drinks for healthier options like sparkling water, avoiding fast foods, and opting for whole grains and non-starchy fruits and vegetables can make a significant difference. Additionally, individuals should aim to reduce their portion sizes, avoid snacking between meals to reduce caloric intake, and eat dinner earlier in the evening, followed by a walk, to help regulate insulin levels.

Effective obesity management, which includes a combination of dietary modifications, portion control, and mindful eating habits, is essential in reducing diabetes risk. Low carbohydrate and Mediterranean diets have also been shown to be effective for weight loss (24).

Physical activity plays a key role in managing insulin sensitivity, as reported in various studies (2527). Engaging in regular exercise, such as brisk walking or jogging, for 150–200 min a week, as recommended by health guidelines, helps regulate blood sugar and manage obesity effectively (22, 28).

Health monitoring is also necessary. Individuals should regularly check their glucose levels based on risk factors and as advised by medical doctors,4 maintain a health diary, and consult with nutritionists to ensure they stay on track with their health goals.

4.2 Community-level interventions

Communities have the power to support individual efforts through collective health promotion activities (29). In Pakistan, religious and community leaders, such as imams and teachers, can be instrumental in raising awareness about diabetes prevention during sermons and other gatherings. For instance, imams can remind the public during Friday khutba (sermon) of the saying of the Prophet Muhammad (PBUH): “Verily your body has right upon you.”

Worship places such as mosques and churches, community centers and other social spaces (i.e., hujras) can be powerful platforms for implementing programs that promote communal health and provide other social services (30), and even more so in a culturally and religiously vibrant Muslim country like Pakistan (31). These places can be equipped with exercise equipment, such as treadmills, and can host community-driven initiatives like fitness challenges, healthy cooking classes, wellness fairs, and other community activities that encourage people to adopt healthier lifestyles (32).

Education and outreach efforts are also critical at the community level. Workshops and seminars focused on diabetes prevention, particularly in community hubs like mosques and schools, can help disseminate important information, as they have been proven effective in promoting overall wellbeing (31, 33). Additionally, establishing diabetes support groups, overseen by medical professionals, can create a supportive network where individuals share experiences and practical strategies for managing the condition—an approach that has been reported as effective in chronic disease management (34, 35).

4.3 Policy interventions at the district, provincial, and federal levels

Various policy approaches in LMICs have been shown to be effective in disease management and other health-related outcomes (36, 37). Pakistan itself has a track record of successful policy approaches in curtailing COVID-19 and increasing immunization rates (38).

Just as Pakistan treated COVID-19 “an existential threat” and mobilized resources and collaboration, policymakers should take similarly coordinated actions at the district, provincial, and federal levels to effectively manage the diabetes crisis.

At the district level, governments can implement awareness campaigns and offer incentives for community members to participate in health programs. Improving infrastructure by funding playgrounds and parks will encourage physical activity, while mobile health clinics can ensure that remote areas have access to screenings and consultations. It is also important to screen for common mental health conditions like depression, which can contribute to stress eating and exacerbate diabetes.

At the provincial level, governments should focus on organizing conferences and workshops with healthcare professionals to raise awareness about diabetes prevention. Allocating funds for gym equipment and health education materials in schools and religious seminaries will further encourage healthy lifestyles. Incorporating diabetes prevention into the school curriculum and promoting research on diabetes management are additional strategies to address this growing crisis.

Finally, at the federal level, broad policy changes are necessary. Islamabad can introduce taxes on sugary drinks and regulate the marketing of unhealthy foods. Nationwide diabetes testing should be made accessible, and comprehensive data collection by the National Institute of Health (NIH) will enable informed decision-making. Public awareness campaigns featuring celebrities and influencers may also help promote healthy living, while educational reforms that include lessons on nutrition and physical activity will equip future generations with the knowledge they need to prevent diabetes. Legislation that prioritizes health budgets and supports diabetes prevention programs is also essential.

5 Conclusion

Addressing Pakistan’s diabetes epidemic requires a coordinated, multi-level approach that engages individuals, communities, and policymakers. Through lifestyle changes including obesity management, community support, and strategic policy interventions, Pakistan can combat the rising prevalence of diabetes and work to reverse the trend. These efforts must be widespread and collaborative, ensuring that every level of society contributes to this urgent public health mission. We acknowledge that this approach is just one of many possibilities, and the policy recommendations we propose are suggestions that, if implemented, can help mitigate the diabetes crisis and improve public health outcomes.

Author contributions

FJ: Writing – original draft. UM: Writing – original draft. AN: Writing – review & editing. ShandK: Writing – review & editing. ShanlK: Writing – review & editing. SS: Writing – review & editing. ZW: Writing – review & editing. MAJK: Writing – review & editing. BW: Writing – review & editing. KK: Writing – review & editing. MSK: Writing – review & editing, Writing – original draft.

Funding

The author(s) declare that no financial support was received for the research and/or publication of this article.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Generative AI statement

The authors declare that no Gen AI was used in the creation of this manuscript.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Footnotes

1. ^https://www.frontiersin.org/research-topics/64734/ensuring-public-health-the-active-role-of-healthcare-professionals/overview

2. ^Insulin resistance refers to a condition where the body’s cells do not respond to insulin effectively (6). Insulin sensitivity, on the other hand, refers to the normal metabolic state where the body efficiently utilizes insulin (39).

3. ^Genetics is also in fact a crucial factor for insulin deficiency in type 1 diabetes.

4. ^According to American Diabetic Association latest guidelines (40), patients with stable glycemic control should have their HbA₁c (Hemoglobin A1c) checked at least twice a year, whereas those whose treatment has changed or whose levels are above target should be tested quarterly.

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Keywords: type 2 diabetes, prevention measures (PM), policy interventions, Pakistan, obesity, public awareness, dietary changes, risk factors

Citation: Jamil F, Mir U, Niazi AG, Kifayat S, Kifayat S, Shafiq S, Wali Z, Khan MAJ, Wali B, Kobra KT and Khan MS (2025) A multi-level approach to reduce exploding type 2 diabetes in Pakistan. Front. Public Health. 13:1514090. doi: 10.3389/fpubh.2025.1514090

Received: 20 October 2024; Accepted: 03 March 2025;
Published: 21 March 2025.

Edited by:

Niccolo Persiani, University of Florence, Italy

Reviewed by:

Gregory Westcott, Beth Israel Deaconess Medical Center and Harvard Medical School, United States
Jasmin Tahmaseb, West Chester University, United States

Copyright © 2025 Jamil, Mir, Niazi, Kifayat, Kifayat, Shafiq, Wali, Khan, Wali, Kobra and Khan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Fazal Jamil, ZmphbWlsQG1lcmN5LmNvbQ==

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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