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CLINICAL TRIAL article
Front. Public Health
Sec. Children and Health
Volume 13 - 2025 |
doi: 10.3389/fpubh.2025.1513358
Association between female cardiometabolic index and infertility: a population-based study
Provisionally accepted- 1 Chengdu University of Traditional Chinese Medicine, Chengdu, China
- 2 Zigong First People's Hospital, Zigong, Sichuan Province, China
- 3 Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
Background: Visceral fat accumulation and dyslipidaemia are associated with infertility symptoms. The cardiometabolic index (CMI) is a comprehensive quantitative measure of central obesity and dyslipidaemia. However, the link between the female CMI and the couple infertility needs to be explored further. Hence, this study aimed to dissect this connection. Methods: The study used a cross-sectional approach to select 1641 female participants from the National Health and Nutrition Examination Survey (NHANES), which was conducted between 2013 and 2020. The natural log–transformed CMI (In-CMI) was used to consider the non-normal distribution of CMI. Logistic regression models adjusted for covariates were employed to investigate the association between the In-CMI and couple infertility. Results: After adjusting for all covariates, each 1 unit increase in the In-CMI was associated with a 34% increase in the incidence of infertility (odds ratio [OR] 1.34, 95% confidence interval [CI] 1.10–1.64, P = 0.004). In addition, the association remained statistically significant after dividing the In-CMI into tertiles (T1, T2, and T3). The T3 group, with the highest In-CMI, showed higher odds of infertility compared with the T1 group (OR 2.11, 95% CI 1.38–3.23, P < 0.001). Subgroup and interaction analyses revealed that the association between the In-CMI and infertility depended on a history of treatment for pelvic infection (P for interaction < 0.05). The inflexion point for a positive linear association between In-CMI and infertility was -0.73. Conclusion: The female CMI is linked to the incidence of couple infertility. Moreover, the female CMI shows significant medical significance for assessing couple infertility risk of childbearing age.
Keywords: Cardiometabolic index, Obesity, Lipid Metabolism, Infertility, NHANES, Cross-sectional study
Received: 18 Oct 2024; Accepted: 22 Jan 2025.
Copyright: © 2025 Junqian, fengya, yuan and jie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
zhu fengya, Zigong First People's Hospital, Zigong, Sichuan Province, China
wang yuan, Chengdu University of Traditional Chinese Medicine, Chengdu, China
wu jie, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
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