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ORIGINAL RESEARCH article

Front. Public Health
Sec. Aging and Public Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1509898
This article is part of the Research Topic Cardiometabolic Diseases: Therapeutic Targets Discovery and Mechanism Study View all 13 articles

Association Between Chinese Visceral Adiposity Index and Risk of New-Onset Hypertension in Middle-Aged and Older Adults with Prediabetes: Evidence from a Large National Cohort Study

Provisionally accepted
Qianhui Wang Qianhui Wang 1*Lanlan Li Lanlan Li 2Linqiang Xi Linqiang Xi 3
  • 1 Xinjiang Medical University, Ürümqi, China
  • 2 Hospital of Xinjiang Production and Construction Corps, Urumqi, China
  • 3 First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Region, China

The final, formatted version of the article will be published soon.

    Purpose: Chinese Visceral Adiposity Index (CVAI) has been found significantly associated with hypertension in general and type-2 diabetes adults. However, the predictive value of CVAI for the incidence of hypertension in adults with prediabetes is unclear. This study aimed to assess the predictive utility of the CVAI for the new onset of hypertension in middle-aged and elderly Chinese individuals with prediabetes.Methods: A prospective cohort study was conducted involving participants aged 45 years and above with prediabetes from the 2011-2012 cohort of the China Health and Retirement Longitudinal Study (CHARLS). Logistic regression models were utilized to investigate the association between CVAI levels and the risk of new-onset hypertension.The study included 2186 participants, among whom 444 (20.31%) developed hypertension. Significantly higher incidence rates of hypertension were observed in individuals belonging to the highest quartile group (Q4) compared to those in the lowest quartile group (Q1) of CVAI (29.41% vs. 14.69%, P<0.001). Multivariate logistic regression analysis indicated that participants in Q4 had a 1.91-fold greater risk of hypertension development compared to those in Q1 (odds ratio (OR): 1.91, 95% confidence interval (CI): 1.49-2.45, P<0.001). The area under the receiver operating characteristic (ROC) curve (AUC) demonstrated that CVAI exhibited superior performance in discriminating individuals at heightened risk of hypertension compared to other obesity-related indices (P<0.001). A subgroup analysis revealed that age may modulate the relationship between CVAI and new-onset hypertension, with a more pronounced interaction observed among participants below 60 years of age (P for interaction: 0.026).Elevated CVAI levels were significantly associated with an increased risk of developing hypertension. CVAI proves to be a reliable and effective tool for risk stratification in middle-aged and elderly Chinese individuals with prediabetes, underscoring its substantial implications for primary prevention of hypertension and 3 public health strategies.

    Keywords: prediabetes, Hypertension, Obesity, Chinese visceral adiposity index, biomarker

    Received: 11 Oct 2024; Accepted: 27 Jan 2025.

    Copyright: © 2025 Wang, Li and Xi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qianhui Wang, Xinjiang Medical University, Ürümqi, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.