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REVIEW article

Front. Public Health
Sec. Radiation and Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1509675
This article is part of the Research Topic Advances in Radiation Research and Applications: Biology, Environment and Medicine View all 6 articles

Unveiling the Impact of CD133 on Cell Cycle Regulation in Radio-and Chemo-resistance of Cancer Stem Cells

Provisionally accepted
Luyao Wu Luyao Wu 1Takanori Katsube Takanori Katsube 2Xiaofei Li Xiaofei Li 3Bing WANG Bing WANG 2Yi XIE Yi XIE 1*
  • 1 Institute of Modern Physics, Chinese Academy of Sciences (CAS), Lanzhou, China
  • 2 National Institutes for Quantum and Radiological Science and Technology (Japan), Chiba, Japan
  • 3 Gansu Nuclear and Radiation Safety Center, Lanzhou, China

The final, formatted version of the article will be published soon.

    The adaptation of malignancy to therapy presents a significant challenge in cancer treatment. The cell cycle plays a crucial role in regulating the evolution of radio-and chemo-resistance in tumor cells. Cancer stem cells (CSCs) are the primary source of therapy resistance, with CD133 being one of the most recognized and valuable cell surface markers of CSCs. Evidence increasingly suggests that CD133 is associated with cancer resistance. The current understanding of the molecular biological function of CD133 is limited, leading to ongoing debates about its role in cancer biology. In this review, we explore recent research and emerging trends related to CD133 through extensive literature and content analysis. It was summarized that new insights into the relationships of CD133 and cell cycle signaling pathways in resistant CSCs. The aim of this review is to provide a foundational understanding of how these signaling pathways and their interactions impact cancer prognosis and inform treatment strategies.

    Keywords: malignancy, cancer stem cells, CD133, Radio-and chemo-resistance, Cell Cycle

    Received: 11 Oct 2024; Accepted: 13 Jan 2025.

    Copyright: © 2025 Wu, Katsube, Li, WANG and XIE. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yi XIE, Institute of Modern Physics, Chinese Academy of Sciences (CAS), Lanzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.