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SYSTEMATIC REVIEW article
Front. Public Health
Sec. Infectious Diseases: Epidemiology and Prevention
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1480428
This article is part of the Research Topic Microbial Resistance and Infection Control in Public Health Care Setting View all 9 articles
Central Line-Associated Bloodstream Infection (CLABSI) Rates in Intensive Care Units of China's Hospitals: a Meta-Analysis
Provisionally accepted- Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
Background and Aim: Various reasons have hindered accurate reporting of the central line-associated bloodstream infection (CLABSI) rates in China’s hospital ICUs. This study conducts a meta-analysis to provide a precise assessment of CLABSI rates in these units.Methods: Adhering to the PRISMA guidelines, a systematic search was conducted in PubMed, Web of Science, Embase, CNKI, Wanfang and Weipu from January 2008 to December 2023. Selection of literature followed strict criteria, ensuring relevant data extraction. A random-effects model facilitated the meta-analysis.Results: The analysis incorporated 23 studies (PubMed: 5, Web of Science: 4, Embase: 1, CNKI: 9, Wanfang: 2, Weipu: 2). It revealed an overall weighted CLABSI rate in China’s ICUs of 2.65‰ (95% CI: 2.57-2.73‰), with 3.12‰ in adult ICU (95% CI: 2.70-3.54‰) and 2.57‰ in pediatric ICUs (95% CI: 2.49-2.66‰). Notably, adult ICUs in North of China recorded the highest rate at 5.13‰ (95% CI: 4.23-6.02‰), and pediatric ICUs in East of China had 3.35‰ (95% CI: 2.85 - 3.85‰).Conclusion: The study indicates that CLABSI rates in China’s ICUs surpass those reported in national healthcare reports and the US CDC-NHSN data. This underscores the urgency for enhanced surveillance and infection control. The findings stress the need for standardized surveillance definitions and methods to truly represent CLABSI epidemiology and develop effective prevention strategies.
Keywords: Central line-associated bloodstream infection, ICU, China, Meta-analysis, CLABSI
Received: 14 Aug 2024; Accepted: 02 Apr 2025.
Copyright: © 2025 Xiang, Cai, Jiang, Chen, Wu and Lv. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qian Xiang, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
Yu Lv, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
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