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ORIGINAL RESEARCH article

Front. Public Health

Sec. Infectious Diseases: Epidemiology and Prevention

Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1420291

COVID-19 vaccines side effects among the general population during the pandemic: A cross-sectional study

Provisionally accepted
Samana Zaidi Samana Zaidi 1Hafsa Abdul Qayyum Hafsa Abdul Qayyum 1Izzah Abdul Qayyum Izzah Abdul Qayyum 1Zakir Khan Zakir Khan 2Taskeen Islam Taskeen Islam 3Naveed Ahmed Naveed Ahmed 4Kathryn L Hopkins Kathryn L Hopkins 5Theresa Sommers Theresa Sommers 5Samar Akhtar Samar Akhtar 1SHAHZAD ALI KHAN SHAHZAD ALI KHAN 6Sumbal Javed Sumbal Javed 6Aamer Ikram Aamer Ikram 7Hashaam Akhtar Hashaam Akhtar 1,6*
  • 1 Yusra Institute of Pharmaceutical Sciences, Yusra Medical and Dental Collage, Zaraj Housing Society, Opposite DHA Phase 2 Gate III, Main G.T. Road, Islamabad, 44000, Pakistan, Islamabad, Pakistan
  • 2 Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan
  • 3 Department of Communication and Media Studies, Fatima Jinnah Women University, Rawalpindi, Punjab, Pakistan
  • 4 Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Islamabad, Pakistan
  • 5 Sabin Vaccine Institute, Washington D.C., District of Columbia, United States
  • 6 Global Health Department, Health Services Academy, Chak Shahzad, Islamabad, 44000, Pakistan, Islamabad, Islamabad, Pakistan
  • 7 Consultant at Armed Forces Institute of Pathology, Rawalpindi, Pakistan, Rawalpindi, Punjab, Pakistan

The final, formatted version of the article will be published soon.

    The general population have depicted concern about the safety and efficacy of the vaccine and its long-term effects on human health. Pakistan being on the verge of the pandemic is in more demand for vaccination and immunization. Therefore, this study aimed to evaluate the COVID-19 vaccines side effects among the general population.A cross-sectional face-to-face study was carried out among individuals who received either the first dosage or both doses of vaccination in twin cities (Islamabad and Rawalpindi) of Pakistan. Data was collected through a self-administered questionnaire. The questionnaire included three sections (socio-demographic, medical history, vaccine, and immunization) with 20 questions. The collected data was analyzed in SPSS (version 25) using descriptive statistics, the chi-square test, and the odd ratio.Results: A total of 2618 participants were included and of them, females (55.3%; n=1449) were more than males. The majority of the participants reported the use of precautionary medicines including vitamin C (1319; 50.4%) followed by paracetamol (n=1249; 47.7%) and mineral supplements (n=616; 23.5%) for COVID-19.In this study, 3.8% (n=99) were unvaccinated and the first and second doses of the vaccine was received by 2519 and 2239 of the participants, respectively. Different types of side effects were highlighted in the current study. The most frequently reported side effects after the first dose of COVID-19 were fever (n=997), pain at the injection site (n=994), muscle pain (n=620), and fatigue (n=482). Additionally, pain at the injection site (n=852), fever (n=815), and muscle pain (n=601) were commonly reported after the 2 nd dose of COVID-19.The lowest reported side effects were swollen lymph nodes and anaphylactic shock. In the current study, people who were previously immunized with the flu and pneumonia vaccine had a lower risk of developing side effects (p <0.05).This study highlights important information about side effects reported due to the COVID-19 vaccinations. Moreover, the use of precautionary medications was also highlighted. These findings could have a valuable impact on designing future comparative studies and developing policies/guidelines for pandemic preparedness.

    Keywords: Vaccine, precautionary medication, Immunization, infodemic, side effects, COVID-19, Pakistan

    Received: 08 May 2024; Accepted: 24 Feb 2025.

    Copyright: © 2025 Zaidi, Qayyum, Qayyum, Khan, Islam, Ahmed, Hopkins, Sommers, Akhtar, KHAN, Javed, Ikram and Akhtar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hashaam Akhtar, Yusra Institute of Pharmaceutical Sciences, Yusra Medical and Dental Collage, Zaraj Housing Society, Opposite DHA Phase 2 Gate III, Main G.T. Road, Islamabad, 44000, Pakistan, Islamabad, Pakistan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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